Can a simple nebulizer mist stop Post-Surgery sore throat?

NCT ID NCT07491991

Completed Symptom relief Sponsor: Qianfoshan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether spraying a mix of budesonide and lidocaine directly on the voice box during thyroid surgery could prevent the common problem of sore throat afterward. 96 adults having thyroid surgery with nerve monitoring were randomly assigned to get either the drug mist or a saltwater mist. The goal was to see if the drug combination reduced pain and other throat symptoms better than plain saline.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: budesonide combined with lidocaine
What this could lead to: If it works, this could provide a simple, non-invasive way to reduce sore throat after thyroid surgery, improving patient comfort and recovery.
What could go wrong: This is a small, single-center Phase 4 trial with only 96 participants. The benefit may be modest or not better than saline, and results may not apply to other surgeries.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEBULIZATION POSTOPERATIVE PAIN THYROID SURGERY

Contacts and locations

Locations

Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University

Jinan, Shandong, 250000, China

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