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Wisdom tooth study probes brain chemicals for clues to pain and anxiety

NCT ID NCT07644065

Knowledge-focused Sponsor: Plovdiv Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 40 people having both wisdom teeth removed, two weeks apart. Researchers measured two natural chemicals in the blood—serotonin and kynurenic acid—before and after surgery to see if they relate to pain and anxiety. The goal was to better understand how these chemicals influence recovery, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ibuprofen, Gabapentin, Placebo
What this could lead to
If successful, this could help explain how the body's natural chemicals affect pain and anxiety after surgery, potentially guiding better pain management.
What could go wrong
This is a small, early-stage observational study with only 40 participants. The findings may not apply to other types of surgery or pain conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Sep 2019

Finished

Sep 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 38 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Bilateral impacted mandibular third molars requiring surgical extraction * Age 18-38 years * Written informed consent * Ability to comply with study procedures Exclusion Criteria: * Systemic inflammatory disease * Autoimmune disease * Neurological disease * Psychiatric disorders * Chronic pain conditions * Use of immunomodulatory medications * Use of psychotropic medications * Use of analgesic medications * Pregnancy * Drug hypersensitivity * Active pericoronitis at enrollment

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder Neuroinflammatory Diseases neuronitis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety Impacted third molar Neuroinflammation Postoperative pain

Contacts and locations

Locations

  • Faculty of Dental Medicine

    Plovdiv, Plovdiv, 4002, Bulgaria

More trials for these conditions

Other studies related to the condition(s) this trial covers.