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Can common anti-inflammatories replace opioids for post-surgery pain?

NCT ID NCT07500454

Symptom relief Sponsor: ISSSTE Hospital Regional "Gral. Ignacio Zaragoza" Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This small pilot study tested whether two NSAIDs (ketorolac and diclofenac) work as well as a weak opioid (tramadol) for pain after minimally invasive surgery. Thirty adults received a single dose of one of the three drugs before surgery, and their pain levels were tracked afterward. The goal is to see if safer, non-opioid options can effectively manage acute postoperative pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tramadol, ketorolac, diclofenac
What this could lead to
If NSAIDs work as well as tramadol, doctors may use them more often for post-surgery pain, reducing reliance on opioids and their side effects.
What could go wrong
This is a small pilot study with only 30 participants, so results may not apply to everyone. It also only tested single doses before surgery, not long-term use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Jun 2024

Finished

Jul 2024

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-55 years * ASA physical status I or II * Body mass index 18.5-34.99 kg/m² * Scheduled for elective minimally invasive surgery under balanced general anaesthesia * Pre-surgical pain NRS = 0 and VRS = "absence" at baseline assessment Exclusion Criteria: * Pregnancy * Known hypersensitivity to any study drug (tramadol, ketorolac, or diclofenac) * Pre-existing acute pain with NRS ≥ 4 or VRS ≥ "moderate" before surgery * Chronic pain with current analgesic use * Withdrawal of consent before premedication administration * Surgical duration exceeding 180 minutes * Conversion from laparoscopic to open surgical approach * Hypersensitivity reaction during study drug administration * Haemodynamic shock of any aetiology during the perioperative period * Requirement for postoperative mechanical ventilation due to anaesthetic-surgical complications

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Conditions

The condition(s) this trial relates to.

Acute Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute pain Postoperative pain

Contacts and locations

Locations

  • Hospital Regional "General Ignacio Zaragoza," ISSSTE

    Mexico City, Mexico City, 09360, Mexico

More trials for these conditions

Other studies related to the condition(s) this trial covers.