ACUTE PAIN

This study is testing whether a focused muscle contraction exercise program can improve body composition, physical abilities, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. Participants will complete 90 exercise sessions and 4 testin…

This study tests a single dose of an experimental painkiller (LY4515100) in 212 people who have moderate-to-severe pain after having their wisdom teeth removed. Participants will be randomly assigned to receive either the drug or a placebo, and researchers will measure pain level…

This study tests whether a special laser treatment (LightForce®) can reduce pain from mild to moderate ankle sprains better than a fake laser. About 108 adults with ankle pain for less than 72 hours will receive either real laser therapy or a sham treatment, plus standard care li…

This study looks at whether a rectus sheath block—a type of nerve block—can improve breathing and reduce pain in adults after major upper abdominal surgery. About 60 participants will receive the block and be monitored for diaphragm movement and pain levels. The goal is to see if…

This study looks at whether giving magnesium sulfate through an IV can help manage pain and reduce the need for strong painkillers in trauma patients in the intensive care unit (ICU). About 156 adults with injuries will receive either magnesium or a saltwater solution. The goal i…

This study tests whether watching relaxing virtual reality (VR) scenes before egg retrieval can reduce pain in women freezing their eggs. One hundred women will be randomly assigned to either standard care or standard care plus a VR relaxation session. Pain levels are measured be…

This study tests two different nerve blocks to see which one provides better pain relief after single-level lower back surgery. About 70 adults aged 18–70 will receive one of the two blocks before surgery. The main goal is to reduce the need for strong painkillers (opioids) after…

This study looks at whether a special numbing injection, called the Twin Block, can reduce jaw muscle pain after wisdom tooth removal. About 48 healthy adults who have pain the day after surgery will receive either the injection or a placebo. The goal is to see if this simple, sa…

This study looks at whether a single session of low-level laser therapy (LLLT) can immediately affect pain threshold and tolerance in healthy adults aged 18 to 35. Participants will receive either real or sham laser treatment, and their pain responses to mild electrical stimulati…

This study tests whether using a virtual reality headset, along with standard pain medicine, can help adults with sickle cell disease feel less pain during a painful crisis in the emergency department. About 30 participants will be split into three groups to compare pain scores a…

This study tests whether a special numbing injection called a Temporo-masseteric Nerve Block can reduce pain after wisdom tooth removal. About 20 adults having their lower wisdom teeth taken out under sedation will receive the injection and then report their pain levels and any p…

This study compares two ways to decide when surgery patients need extra pain medicine. One method uses a standard pain score, while the other also considers how much pain limits movement. The goal is to give painkillers only when truly needed, reducing overtreatment. About 76 adu…

This study tests whether a very short (7-minute) mindfulness exercise can reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation. About 80 participants will be randomly assigned to receive the mindfulness intervention or standard care. The goal is to …

This study compares two types of nerve blocks to manage pain after heart surgery through the breastbone. About 50 adults will receive either one block or a combination of two blocks. The goal is to find which method provides better pain relief and reduces the need for strong pain…

This study tests two ways of numbing back muscles after lumbar spine surgery to see which provides better pain control. Sixty adults having single-level back surgery will receive either a standard or a modified nerve block. The goal is to reduce the need for strong painkillers an…

This study tests whether listening to a short mindfulness audio while waiting for an orthopedic appointment can reduce pain. About 400 adults will be randomly assigned to either the mindfulness exercise or a standard injury management talk. The goal is to see if this simple, no-d…

This study compares two types of nerve blocks for pain after inguinal hernia surgery. One is a newer technique called the anterior iliac block, and the other is a standard ilioinguinal/iliohypogastric block. The goal is to see which provides longer pain relief and higher patient …

This study compares two medications, dexmedetomidine and dexamethasone, added to a standard nerve block for arm surgery. The goal is to see which one helps the block work faster, last longer, and reduce the need for painkillers afterward. About 44 adults aged 18-70 having upper l…

This study compares two methods of giving a pain-relieving shot (TAP block) after a planned C-section: one guided by ultrasound and one done by the surgeon during the operation. Fifty women will take part to see which method works better and faster for controlling pain after surg…

This study watches 1,000 adults having surgery to see if things like worry about pain, sleep trouble, and anxiety change how well numbing medicine works. Researchers also track how much opioid painkiller people need and if long-term pain develops. No new treatment is tested—the g…

This study is testing a new, non-invasive device that measures pain in children and teens by tracking changes in pupil size. Researchers want to see if it can provide a more objective way to assess pain than current methods. The study will include 100 participants ages 6 to 21 wh…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to see if daily changes in these factors can predict whether pain becomes long-term or flares up. A smaller group will also …

This study aims to make sure that pain assessment tools for infants (0 to under 2 years old) are easy to understand and cover all important signs of pain. About 60 caregivers and clinicians will be interviewed to check if the tools are clear and complete. The goal is to create re…

This study looks at whether the intense pain people feel right before emergency surgery can lead to pain that lasts for months afterward. Researchers will follow about 700 adults having emergency orthopedic or abdominal surgery. They want to see if the level of pain before surger…

This study looks at whether oxytocin, a natural hormone, can change how nerves send pain signals after mild heat. Sixty healthy adults will receive either oxytocin or a placebo through an IV. Researchers will measure nerve activity and pain scores before and after heating a small…

This study tests a new drug that blocks a specific nerve channel (NaV1.8) to see which types of pain it reduces. Healthy volunteers receive tiny, safe doses injected into the skin and undergo brief pain tests like heat, cold, and pressure. The goal is to understand pain better an…