Acute pain

This study tests a new intravenous medicine called Combogesic IV, which combines two common pain relievers (acetaminophen and ibuprofen) into one infusion. It will involve 60 children aged 2 to 17 with acute pain who need IV pain relief. The goal is to see how the body processes …

This study tests whether a 7-minute guided mindfulness exercise can help reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation for spine pain. Half of the 80 participants will do the mindfulness exercise, while the other half will receive standard pa…

This study tests two simple, no-cost methods to reduce pain and fear in children aged 6-12 during blood draws: rhythmic skin tapping by a nurse just above the needle site, and the child humming an 'mmmm' sound. Both techniques are based on the idea that touch and vibration can pa…

This trial tests whether the angle of the ultrasound probe during a nerve block affects pain relief after breast surgery. About 70 adults scheduled for breast surgery will receive a serratus anterior plane block with bupivacaine, using either a transverse or longitudinal probe or…

This trial tests whether a combination of two ultrasound-guided nerve blocks (PECS II and superficial PIP) can provide pain relief and recovery quality comparable to the standard thoracic paravertebral block after mastectomy. The standard block is effective but carries a risk of …

This trial tests whether adding ketamine or dexmedetomidine to a standard numbing drug (bupivacaine) in a scalp block improves pain control and reduces opioid use during brain tumor removal. About 80 adults undergoing supratentorial brain tumor surgery will receive one of the two…

This study tests whether listening to a 1- or 2-minute guided mindfulness audio can reduce pain in people waiting for orthopedic care. 300 adults will be randomly assigned to one of two mindfulness exercises or a control. The goal is to see if a brief, easy-to-use technique can m…

This study tests whether an ultrasound-guided retrolaminar block (a numbing injection near the spine) can lower the amount of opioids patients need after lumbar spine fusion surgery. Forty-four adults will be randomly assigned to receive either the active block or a sham injectio…

This study tests whether a numbing injection called Twin Block can reduce jaw muscle pain and the need for opioid painkillers after wisdom tooth removal. About 48 healthy adults who have jaw pain the day after surgery will receive either the Twin Block or a placebo. Researchers w…

This study compares three intravenous painkillers—fentanyl, tramadol, and ibuprofen—given through a patient-controlled pump after lung surgery. The goal is to see which one controls pain and helps patients breathe better in the first 72 hours after surgery. The trial will include…

This Phase 2 trial tests a single oral dose of LY4515100 against a placebo in 212 people with moderate-to-severe pain after having their wisdom teeth removed. The goal is to see if the drug safely reduces pain intensity and how quickly it works. Participants stay in a research un…

This study compares two types of nerve blocks for pain relief after inguinal hernia surgery: the standard ilioinguinal/iliohypogastric block and a newer anterior iliac block. Researchers want to see which provides longer pain relief and higher patient satisfaction. The trial will…

This study tests if watching relaxing virtual reality (VR) scenes before an egg retrieval procedure can lower pain. One hundred women having elective egg freezing will either get standard care or standard care plus a VR relaxation session. Pain levels are measured with a simple 0…

This study compares two regional anesthesia techniques to manage pain in 50 adults undergoing heart surgery via a chest incision. One group receives an Erector Spinae Plane Block, while the other gets a combination of Superficial Parasternal Intercostal Plane Block and Serratus A…

This study compares two common medications, dexmedetomidine and dexamethasone, when added to a nerve block for arm surgery. The goal is to see which one helps the block work faster, last longer, and reduce the need for painkillers afterward. About 44 adults aged 18-70 will take p…

This study tests whether a new pain scale that considers both pain level and ability to move can better guide when to give extra painkillers after surgery. About 76 adults having scheduled surgery will be randomly assigned to receive rescue pain medication based on either the sta…

This study tests two different nerve block techniques to manage pain after lumbar spine surgery. Sixty adults undergoing single-level back surgery will receive either a standard or a modified block. The goal is to see which method reduces the need for opioid painkillers and impro…

This study tests two different nerve blocks to see which one works better for pain after single-level lumbar disc surgery. 70 adults will receive one of the blocks before surgery, and their pain and opioid use will be tracked for 24 hours. The goal is to find a more effective way…

This study tests two methods of delivering a TAP block—a type of pain shot—after a planned C-section. One method uses ultrasound to guide the needle, the other is done by the surgeon during the operation. The goal is to see which approach provides better pain control and is faste…

This study tests whether using virtual reality (VR) alongside standard care can reduce pain for adults with sickle cell disease who are in the emergency department with a painful crisis. About 30 participants will be split into three groups to compare pain scores and comfort. The…

This study tests whether a special numbing injection called a temporo-masseteric nerve block (TMNB) can reduce pain after wisdom tooth removal. About 20 adults having their lower wisdom teeth taken out under sedation will receive the injection and then report their pain levels an…

This study tests whether a continuous intravenous infusion of magnesium sulfate can reduce pain and the need for narcotic painkillers in critically ill trauma patients admitted to the intensive care unit. Researchers will compare magnesium to a placebo (normal saline) in 156 adul…

This study is testing whether a focused muscle contraction exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans. Twenty-five veterans with pain, fatigue, or low energy will do 90 exercise sessions over 18 …

This study is testing whether a rectus sheath block, a numbing injection into the abdominal wall, can improve breathing and reduce pain in 60 adults undergoing major upper abdominal surgery. Participants will receive the block and be monitored for diaphragm movement and pain leve…

This study follows 200 women having planned cesarean deliveries under spinal anesthesia to see which factors predict severe pain in the first 24 hours after surgery. Researchers will record details before, during, and after the operation, including anxiety levels and pain scores.…

This study aims to improve how pain is assessed and managed in premature babies in the neonatal intensive care unit (NICU). Researchers are using machine learning to analyze video, brain activity, heart rate, and breathing patterns to better distinguish between painful and non-pa…

This study tests whether a nasal spray containing vasopressin, a brain chemical involved in social bonding, can enhance the ability to learn pain relief by watching another person. Healthy adults receive either vasopressin or a placebo spray, then watch a video of someone experie…

This study looks at how a person's mental state—like anxiety, sleep problems, and fear of pain—affects how well numbing medication works during surgery. Researchers will follow 1,000 adults to see if these factors change pain levels, opioid use, and the chance of long-term pain. …

This study looks at whether oxytocin, a natural hormone, can change how nerves react to light touch and painful pressure after a small area of skin is heated. Sixty healthy adults will receive either oxytocin or a placebo through an IV, and a tiny needle will record nerve signals…

This study tests a new device that measures pain by looking at changes in pupil size after a gentle electrical stimulation. Researchers will enroll 100 children and teens ages 6 to 21 who are having surgery or bone marrow transplant. The device is non-invasive and does not change…

This study looks at whether the intense pain people feel right before emergency surgery can turn into chronic pain that lasts for months. Researchers will follow 693 adults having emergency orthopedic or abdominal surgery. They want to see if the level of pain before surgery pred…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…

This study involves interviews with 60 caregivers and clinicians to see how well they can describe and report acute pain in infants and young children under 2 years old. The goal is to create reliable tools for measuring pain in future clinical trials. The study does not test any…