ACUTE PAIN

This study is testing a dental numbing injection called the 'Twin Block' to see if it can reduce jaw muscle pain and the need for opioid painkillers after wisdom tooth removal. Researchers will enroll 48 healthy adults who have significant jaw muscle pain the day after their proc…

This study is testing if giving a continuous magnesium drip through an IV can help manage pain in adults who are critically injured and in the ICU. The goal is to see if magnesium can safely reduce patients' pain scores and their need for strong opioid painkillers. Researchers wi…

This study is testing a new way to decide when to give extra pain medicine after surgery. Researchers want to see if using a scale that measures both pain level and a patient's ability to move around leads to better decisions than using a pain number alone. They will compare two …

This study is testing whether a short, audio-recorded mindfulness practice can help reduce pain for patients sitting in an orthopedic clinic waiting room. Researchers will compare the mindfulness audio to standard injury management advice to see which is more effective. The goal …

This study is testing if a specific type of pain-blocking injection, given after major stomach surgery, can help patients breathe more easily. Researchers will measure how well the diaphragm moves and how much pain patients feel after the procedure. The goal is to see if this pai…

This study is testing whether a very short, 7-minute mindfulness session can help reduce pain and anxiety for people undergoing specific spinal procedures. Researchers will enroll 80 adults who are having either a kyphoplasty or radiofrequency ablation. The goal is to see if this…

This study aims to see which of two add-on drugs, dexmedetomidine or dexamethasone, works better when mixed with a standard numbing shot for arm surgery. Researchers will give the nerve block to 44 adults having upper limb surgery to see which drug helps the numbness start faster…

This study is testing whether using a virtual reality (VR) headset can help reduce pain for adults with sickle cell disease who come to the emergency room with a severe pain crisis. It will add VR sessions to the usual pain medications to see if it makes patients feel better. Res…

This study aims to find the best way to manage pain after a planned cesarean section. It will compare two methods of delivering a numbing medication to the abdominal wall: one guided by ultrasound and one done by the surgeon during the procedure. Researchers will measure how well…

This study is testing whether a special laser treatment can help reduce pain from a recent ankle sprain. Researchers will compare a real laser device to a fake one, with both groups also receiving standard care like rest, ice, and exercises. The goal is to see if the laser provid…

This study compares two different nerve-blocking techniques to see which one better controls pain after single-level lumbar disc surgery. Researchers will measure how much pain medication patients need and their pain levels after surgery. The goal is to find the most effective me…

This study is testing if a single, quick session of low-level laser therapy (LLLT) can immediately make healthy adults less sensitive to pain. Researchers will compare the real laser to a fake, non-working laser to see if it truly changes how much pain people can feel and withsta…

This study is testing a special numbing injection, called the Temporo-masseteric Nerve Block (TMNB), given right after wisdom tooth removal. The goal is to see if it can reduce post-surgery pain and the need for strong opioid painkillers. Researchers will follow 20 participants f…

This study is testing whether using relaxing virtual reality (VR) before an egg retrieval procedure can help reduce pain. Women undergoing elective egg freezing are randomly assigned to receive either standard care or standard care plus a 20-minute VR session with calming nature …

This study compares two different nerve-blocking techniques to manage pain after heart surgery through the breastbone. Researchers will test which method provides better pain relief and recovery for 50 patients undergoing this type of surgery. The goal is to improve comfort and r…

This study compares two different nerve block techniques for managing pain after lumbar spine surgery. Researchers want to see which method provides better pain relief while reducing the need for opioid pain medications. The study involves 60 adults undergoing single-level back s…

This study is testing whether a specific, long-term exercise program can help U.S. veterans feel better. It will see if the workouts improve body composition, physical strength, and reduce symptoms of pain, fatigue, depression, and PTSD. Over 18 months, 25 participants will atten…

This study aims to understand how daily pain, mood, and activities are connected, especially as acute pain transitions to chronic pain. Researchers will enroll 800 people with acute pain, chronic pain, or no pain to use a smartphone app (SOMA) for four months to track their daily…

This study aims to test and improve tools used to measure pain in infants and young children under 2 years old. Researchers will conduct interviews with 60 caregivers and clinicians to see if the assessment questions are clear, complete, and relevant. The goal is to create reliab…

This study aims to understand if the hormone oxytocin changes how nerves in the skin respond to touch and pressure after the skin is briefly heated. Researchers will compare oxytocin to a placebo in 60 healthy volunteers. They will measure nerve signals directly using a fine need…

This study is testing a new, non-invasive device that measures changes in a child's pupil size to try to get an objective reading of their pain. It involves 100 children and teens, aged 6 to 21, who are having planned surgery or a bone marrow transplant at Children's National Hos…

This study aims to understand if severe pain experienced just before emergency surgery increases the risk of developing long-term chronic pain after the operation. Researchers will follow 693 adults undergoing emergency bone or abdominal surgery in France. The goal is to identify…