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Which painkiller works best after lung surgery? new trial aims to find out

NCT ID NCT07610408

Symptom relief Sponsor: Ankara Etlik City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares three intravenous painkillers—fentanyl, tramadol, and ibuprofen—given through a patient-controlled pump after lung surgery. The goal is to see which one controls pain and helps patients breathe better in the first 72 hours after surgery. The trial will include 135 adults undergoing video-assisted lung surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fentanyl, tramadol, and ibuprofen (given intravenously via patient-controlled pump)
What this could lead to
If this trial succeeds, it could identify which IV painkiller works best for controlling pain and supporting breathing after lung surgery.
What could go wrong
This is a small, early-phase study (135 people) comparing existing drugs, so results may not apply to everyone. Side effects like nausea or drowsiness are possible with these painkillers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 135 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. \- Patients aged 18 to 80 years. 2. \- ASA (American Society of Anesthesiologists) Physical Status Score of I-III. 3. \- Body Mass Index (BMI) between 18 and 35 kg/m². 4. \- Undergoing elective thoracic surgery via Video-Assisted Thoracoscopic Surgery (VATS). 5. \- Voluntary participation confirmed by signing the written Informed Consent Form. Exclusion Criteria: 1. \- Age below 18 or above 80 years. 2. \- Advanced organ failure (e.g., severe hepatic or renal impairment). 3. \- ASA physical status \> III. 4. \- History of chronic pain treatment or long-term opioid use. 5. \- BMI \< 18 kg/m² or \> 35 kg/m². 6. \- Pregnancy or breastfeeding. 7. \- Limited cooperation due to dementia or uncontrolled psychiatric disorders. 8. \- Communication barriers (inability to communicate in the native language). 9. \- History of substance or drug abuse. 10. \- Known allergy or contraindication to the study drugs (Fentanyl, Tramadol, or Ibuprofen). 11. \- Contraindication to regional block placement (e.g., infection at the injection site).

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Conditions

The condition(s) this trial relates to.

Acute Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute pain Patient-controlled analgesia Postoperative pain Postoperative pain after thoracic surgery Thoracic surgery, video assisted

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ankara Etlik City Hospital, Department of Anesthesiology and Reanimation

    RECRUITING

    Ankara, Keçiören, 06010, Turkey (Türkiye)

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