ACUTE PAIN

This study tested whether a genetic test can help doctors choose safer and more effective pain medicines after surgery. About 1,600 people having planned surgeries were randomly assigned to get either immediate genetic testing to guide their pain treatment or standard care. The g…

This study looked at whether a genetic test can help doctors choose the best pain medicine for women after gynecologic surgery. 112 women were randomly assigned to have their painkiller choice guided by a genetic test or to receive standard care. The goal was to see if using gene…

This study tested a new medicine called MR-107A-02 to see if it can safely reduce pain after hernia repair surgery. About 579 adults took part, comparing the new drug to a placebo (fake pill) and an active painkiller. The goal was to measure pain intensity and the need for extra …

This study tested a new drug called LTG-001 to see if it can safely reduce pain after a tummy tuck (abdominoplasty). 343 adults took the drug or a placebo for 48 hours after surgery and reported their pain levels. The goal was to find the best dose for pain relief and to see if i…

This study tested whether giving patients a brief lesson about mindfulness before a short meditation session helps them feel less pain while waiting at an orthopedic clinic. Over 600 adults took part, and researchers measured changes in how unpleasant and intense their pain felt.…

This study tested a new pain medicine called cebranopadol in 240 adults who had bunion surgery. The goal was to see if it safely reduces moderate to severe pain better than a placebo or another painkiller. Participants rated their pain and satisfaction, and researchers tracked ho…

This study tested a mobile app called OPY that helps patients manage pain and safely use opioids after surgery. Over 3,400 adults who had outpatient surgery and received an opioid prescription used the app to track pain, get tips, and receive reminders to reduce opioid use. The g…

This study tested whether a longer-lasting pain medicine (liposomal bupivacaine) given as a nerve block before breast surgery could reduce the need for opioid painkillers after surgery compared to the standard medicine (bupivacaine). 112 adults having partial mastectomy took part…

This study tested a new pain medication called cebranopadol in 279 people who had a tummy tuck (abdominoplasty). The goal was to see if it safely reduces moderate to severe pain after surgery compared to a placebo. Participants received either the drug or a dummy pill, and pain l…

This study tested two similar pain medicines, esketamine and ketamine, in 74 adults with severe pain in the emergency room. The goal was to see which one causes fewer disturbing side effects like dizziness or hallucinations while still relieving pain quickly. Both drugs are given…

This study tested whether an experimental painkiller called XG005 can safely reduce pain after bunion surgery. About 450 adults took either a low dose, high dose, or a placebo pill. Researchers measured pain levels over 48 hours using a standard 0-to-10 pain scale.

This study looked at whether a continuous nerve block (a small tube that delivers numbing medicine for longer) can improve recovery after total knee replacement surgery. 60 adults having knee replacement as outpatients or short-stay were included. The goal was to see if this appr…

This study looked at 1000 adults with sudden low back pain who were at risk for it becoming a long-term problem. Researchers compared spinal manipulation plus guided self-care against standard medical care. The goal was to see if these treatments could reduce pain and disability …

This study looked at whether common anti-inflammatory drugs (NSAIDs) work as well as a weak opioid (tramadol) for pain after minimally invasive surgery. Thirty adults were given one of three pain medicines before surgery. Their pain levels were checked for 90 minutes after surger…

This study tested whether acupuncture can help manage acute pain in the emergency department. Researchers enrolled 290 adults with moderate to severe pain from injuries like back or abdominal pain. Participants were randomly assigned to receive either acupuncture or usual care, a…

This study tested a new pain medicine called PBK_L1704 in 182 people who had foot surgery (bunionectomy) in South Korea. The goal was to see if it relieves moderate to severe pain better than a placebo (sugar pill) over 48 hours. Participants rated their pain on a 0-10 scale, and…

This study looked at whether a special ultrasound-guided nerve block, called RIFP, can help control pain after laparoscopic gallbladder removal. 77 adults having this surgery received either the block or standard care. The goal was to see if the block reduces the need for extra p…

This study looked at whether a specific nerve block (external oblique intercostal block) can reduce pain after laparoscopic sleeve gastrectomy, a weight-loss surgery. Twenty patients aged 18-65 participated. Researchers measured how much pain relief the block provided and how muc…

This study tested two different methods to control pain after wrist fracture surgery. 96 adults received either a long-lasting numbing medicine or a sedative added to a standard nerve block. The goal was to see which approach provides better pain relief and helps patients recover…

This study tested whether a toy dog that mimics breathing could distract toddlers (ages 1-3) during blood draws. Eighty children were split into two groups: one used the breathing toy, the other received standard care. The toy group had 51% less pain, 72% less crying, and calmer …

This study tested a drug called suzetrigine for managing acute pain after specific surgeries, like laparoscopic or arthroscopic procedures. It involved 47 adults and looked at how well the drug worked and its safety when used with other pain treatments. The goal was to see if pat…

This study tested a new medicine called MR-107A-02 to see if it can safely relieve pain after bunionectomy (foot surgery). About 410 adults took part. The goal was to measure how well the drug reduces pain and whether it can cut down the need for stronger opioid painkillers.

This study looked at whether arm massages with special oils (sesame or sesame-lavender) could reduce acute arm pain and anxiety in women after mastectomy surgery. 90 women were split into three groups: one got massage with sesame oil, one with sesame-lavender oil, and one with pl…

This study tested a medicine called suzetrigine for treating short-term pain after cosmetic or reconstructive surgery. About 100 adults took the drug as part of a combination of pain treatments. The goal was to see if it worked well and was safe.

This early-stage study tested a new drug called JKN2306 in 44 healthy adults in China. The main goal was to check if the drug is safe and how the body processes it, including the effect of food. Since this was a phase 1 trial in healthy people, it does not provide any information…

This study looked at whether a short gratitude exercise can change how people feel pain. 145 healthy adults took part in a cold water test to measure pain. Researchers also checked if certain genes made a difference. The goal was to learn more about the link between positive thin…

This study looked at whether the type of anesthesia used during hernia surgery affects pain levels afterward. Ten men having hernia repair were randomly assigned to receive either total intravenous anesthesia (TIVA) or inhaled anesthesia. Researchers measured pain right after sur…

This study looked at whether genetic testing can help doctors choose better medicines for depression, acute pain, and chronic pain. Over 4,200 people were screened to join one of three separate trials. The goal was to see if matching drugs to a person's genes improves outcomes co…

This study looked at how many opioid pain pills patients actually take after leaving the emergency room for acute pain like fractures or kidney stones. Over 2,200 adults from six Canadian hospitals recorded their pain and pill use in a diary for two weeks. The goal was to help do…

This study tested a single dose of a new experimental drug called SBS-1000 in 48 healthy adults. The main goal was to check for side effects and see how the drug moves through the body. This is an early safety study, so it does not test if the drug actually relieves pain.

This study looked at how oxytocin, a natural brain hormone, affects pain from heat. 25 healthy adults and people with chronic pain rated their pain during skin heating before, during, and after receiving oxytocin through an IV. The goal was to understand how oxytocin works in the…

This study followed 761 adults who were sent home from the emergency room with a prescription for opioid painkillers for acute pain. Researchers called patients at 1 week, 1 month, and 3 months to ask how many pills they took, how well their pain was controlled, what side effects…