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Does your anesthesia choice affect pain after hernia surgery?

NCT ID NCT02527083

Knowledge-focused Sponsor: VA Pittsburgh Healthcare System Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether the type of anesthesia used during hernia surgery affects pain levels afterward. Ten men having hernia repair were randomly assigned to receive either intravenous propofol or inhaled sevoflurane. Researchers measured pain right after surgery and over the long term to see if one method led to less pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Propofol, sevoflurane, remifentanil, ketamine
What this could lead to
If it works, this could point toward choosing anesthesia to reduce long-term pain after hernia surgery.
What could go wrong
This is a very small, early-phase study with only 10 participants, so results may not apply broadly. The effect of anesthesia on chronic pain is still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

10 people

The number who actually took part.

Start date

Jan 2015

Finished

Jun 2019

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All male patients undergoing herniorrhaphy surgery that requires general anesthesia. Exclusion Criteria: * Subjects unable to communicate directly with the investigators, due to being non-English speaking, loss of hearing, or incompetence. * A history of malignant hyperthermia, pseudocholinesterase deficiency, or other disease that prevents anesthetic randomization. * Pain-related disorders such as fibromyalgia or other chronic pain syndromes. * Emergency surgery.

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Conditions

The condition(s) this trial relates to.

Acute Pain Chronic Pain chronic pain syndrome Hernia hiatus hernia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute pain Anesthesia, intratracheal Anesthesia, intravenous Chronic pain Hernia

More trials for these conditions

Other studies related to the condition(s) this trial covers.