ACUTE PAIN

This study is testing an intravenous pain medicine called Combogesic® IV, which combines ibuprofen and acetaminophen, in children aged 2 to 17 with acute pain. The goal is to see how the body processes the drug and to confirm it is safe. Participants will receive the medicine eve…

This study compares two simple methods—cold spray and squeezing a stress ball—to standard care for reducing pain during a shot in the muscle. Sixty-six adults getting a common painkiller injection will be randomly assigned to one of the three groups. The goal is to see which appr…

This study tests whether a numbing injection (retrolaminar block) given before lumbar spine fusion surgery can lower the amount of opioids needed for pain afterward. About 44 adults will be randomly assigned to receive either the real block or a sham injection. Researchers will t…

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This study tests whether listening to a short, guided mindfulness recording can help reduce pain in people waiting for orthopedic care. About 300 adults will be randomly assigned to different lengths of mindfulness practice or a control group. The goal is to see if even a brief s…

This study tests whether a special nerve block (M-TAPA) can reduce pain and the need for strong painkillers after open-heart surgery. About 80 adults having elective open-heart surgery will receive either the block plus standard care or standard care alone. The goal is to see if …

This study looks at three simple methods—breastfeeding, using a stress ball, or wearing virtual reality goggles—to help first-time mothers feel less pain and anxiety during episiotomy repair (stitching after birth). About 120 women will be randomly assigned to one of these groups…

This study compares two types of ultrasound-guided nerve blocks for pain control after laparoscopic gallbladder removal. Ninety adults scheduled for surgery will receive either a recto-intercostal fascial plane block or a transversus abdominis plane block. The goal is to see whic…

This study tests a small, non-drug device called ShotBlocker to see if it can reduce pain and anxiety when inserting an IV. About 100 adults will be randomly assigned to either use the device or receive standard care. The goal is to find a low-cost, easy way to improve patient co…

This study tests a special gel applied to the skin to see if it can quickly reduce pain from shingles. About 30 adults with shingles pain will get one application of the gel. The main goal is to see if pain drops within 2 minutes and stays lower for 24 hours.

This study tests a new method to understand how two pain medicines, pregabalin and naproxen, relieve different types of pain in healthy adults. Up to 25 participants will receive each medicine and a placebo in random order, and undergo short pain tests like cold water and sunburn…

This study tests two different methods of giving a nerve block to numb the front of the belly. 25 healthy adults will get one of two ultrasound-guided injections to see which spreads the numbing medicine better. The goal is to improve pain control after abdominal surgery.

This study involves 14-18 healthy volunteers who will receive three different types of quadratus lumborum blocks on separate days. The goal is to compare how each block affects skin sensation and leg strength. Results will help doctors choose the best block for postoperative pain…

This study will use a special brain imaging technique (fNIRS) to measure how virtual reality (VR) changes brain activity and reduces pain in children aged 6-17 who have burn injuries. Four children will have their brain signals recorded during burn dressing changes with and witho…