Acute pain

Traumatic rib fractures cause severe chest pain that makes breathing and coughing difficult. This trial compares two versions of an ultrasound-guided erector spinae plane block, a nerve block that numbs the chest wall. Adults with recent rib fractures receive bupivacaine plus eit…

Researchers at Stanford University are studying whether suzetrigine, a non-opioid pain medicine, can reduce the amount of oxycodone adults need after tonsillectomy or similar throat surgery. The trial enrolls 58 adults scheduled for these procedures. Participants receive suzetrig…

This Phase 2 trial tests an experimental painkiller called GRT7040 in about 400 adults who have acute pain after bunionectomy, a common foot surgery. Participants receive one of three doses of GRT7040, a placebo, or a standard painkiller (hydrocodone/acetaminophen) for up to 48 h…

This trial tests whether using a weighted blanket during a hospital stay can reduce pain and anxiety in adults recovering from traumatic injuries. Half of the 50 participants will receive a weighted blanket, while the other half gets a standard hospital blanket. Researchers will …

This study tests whether adding a long-acting form of bupivacaine to the standard painkiller can prevent the sudden severe pain that often occurs when a nerve block wears off after orthopedic surgery. Researchers will compare the combination against the standard painkiller alone …

This trial tests whether adding suzetrigine (Journavx), a non-opioid pain medicine, to the usual pain regimen helps adults recover more comfortably after total ankle replacement. Adults aged 18 to 75 scheduled for a first-time ankle replacement can join, and all participants rece…

This study looks at whether a specific nerve block, called the Serratus Posterior Superior Intercostal Plane Block, can reduce pain and the need for strong painkillers after anterior cervical discectomy and fusion (ACDF) surgery. Researchers will compare outcomes between patients…

This trial compares two types of nerve blocks given before hip replacement surgery to control pain afterward. One is the standard supra-inguinal fascia iliaca compartment block (SI-FICB), and the other is a newer quadro-iliac plane block (QIPB). The study includes adults aged 18-…

This study tests a special gel applied to the skin to see if it can quickly reduce pain from shingles. Thirty adults with shingles-related pain will receive a single application of the gel. Researchers will measure pain levels before and after application, focusing on relief with…

This study tests a small, non-drug device called ShotBlocker to see if it can reduce pain and anxiety when placing an IV. One hundred adults who need an IV will be randomly assigned to either use the ShotBlocker or receive standard care. The goal is to find a simple, low-cost way…

This study looks at three simple methods—breastfeeding, using a stress ball, or wearing virtual reality goggles—to help first-time mothers feel less pain and anxiety during episiotomy repair (stitching) after giving birth. About 120 women will be randomly assigned to one of these…

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This study tests whether a modified nerve block called M-TAPA, given before open-heart surgery, can reduce pain and the need for strong painkillers (opioids) afterward. The block is injected under ultrasound guidance near the ribs. Eighty adults having elective open-heart surgery…

This study compares two simple methods—cold spray and squeezing a stress ball—to standard care for reducing pain during a shot. 66 adults getting a muscle injection will be randomly assigned to one of three groups. Pain levels will be measured right after the injection to see whi…

This pilot study will test a new method to see how two pain medicines, naproxen and pregabalin, work in healthy adults. Up to 25 participants will receive each medicine and a placebo in random order. They will undergo several short, controlled pain tests, like a cold water hand b…

Researchers are testing whether stimulating the vagus nerve through the skin of the neck changes how much acute pain healthy adults feel. About 20 adults wear a cap that records the brain's electrical signals while they place their hands in cold water up to three times. Each pers…

This study will use a special brain scanner to see how virtual reality (VR) affects pain in children aged 6-17 with burns. Four children will have their brain activity measured during burn dressing changes, both with and without VR. The goal is to find brain markers that show whe…

This observational study builds a national registry in Switzerland to collect real-world data from people receiving treatment for acute or chronic pain. Researchers track pain intensity, daily function, and quality of life over time using standard questionnaires. The goal is to u…

This study looks at severely injured adults with multiple traumatic injuries who receive one or more nerve blocks for pain. Researchers want to see if having more blocks improves pain control, reduces opioid use, and helps patients regain mobility faster, or if it increases risks…

This study tests three different ways to numb the abdomen in healthy volunteers to see which works best. Each volunteer gets all three blocks on separate days, and researchers map the numb areas and check leg strength. The goal is to improve pain relief after surgery without usin…

This study tests two different ultrasound-guided injection methods for numbing the abdominal wall in 25 healthy adults. One method uses a sideways (transverse) needle approach, the other a lengthwise (longitudinal) approach. Researchers will measure how much skin area becomes num…

This early-phase trial investigates whether m-Cresol, a preservative used in many injectable medications like insulin, causes pain at the injection site. Eighteen healthy volunteers will receive three injections in their belly: one with a low concentration of m-Cresol, one with a…