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New nerve block could cut opioid use after heart surgery

NCT ID NCT07232979

Symptom relief Sponsor: Bursa City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a modified nerve block called M-TAPA, given before open-heart surgery, can reduce pain and the need for strong painkillers (opioids) afterward. The block is injected under ultrasound guidance near the ribs. Eighty adults having elective open-heart surgery will be randomly assigned to receive either the M-TAPA block plus standard care or standard care alone. The main goal is to see if the block lowers opioid use in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine (a local anesthetic) injected as a nerve block
What this could lead to
If it works, this could provide a better way to manage pain after open-heart surgery, reducing the need for strong opioids and their side effects.
What could go wrong
This is a small, early-stage trial (80 people) testing a technique that may not prove effective for all patients. Nerve blocks carry risks like infection or bleeding, though rare.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 to 85 years with ASA physical status II-III who are scheduled to undergo elective open-heart surgery will be included. Exclusion Criteria: Patients who refuse to participate in the study Patients with coagulopathy Patients with a history of allergy or toxicity to local anesthetics Patients with hepatic or renal failure Patients with uncontrolled diabetes mellitus Patients with uncontrolled hypertension Mentally disabled patients Patients receiving chronic pain therapy (opioid use) Patients using antidepressant medications Patients with neuropathic pain Patients with infection at the injection site Pregnant, suspected pregnant, or breastfeeding women

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Conditions

The condition(s) this trial relates to.

Acute Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute pain Modified thoracoabdominal nerve block through the perichondrial approach M tapa Open heart surgery Postoperative pain

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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Other studies related to the condition(s) this trial covers.