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New nerve block aims to slash opioid use after spine fusion

NCT ID NCT07291388

Symptom relief Sponsor: Pontificia Universidad Catolica de Chile Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study tests whether an ultrasound-guided retrolaminar block (a numbing injection near the spine) can lower the amount of opioids patients need after lumbar spine fusion surgery. Forty-four adults will be randomly assigned to receive either the active block or a sham injection, and all will get standard pain medicines. Researchers will track opioid use, pain scores, and recovery quality for three days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
retrolaminar block with bupivacaine and epinephrine
What this could lead to
If it works, this could offer a way to reduce opioid use and improve pain control after spine surgery.
What could go wrong
This is a small, early-stage trial with only 44 participants. The sham group may also show benefits, and results may not apply to all spine surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 44 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-75 years, scheduled for lumbar spine fusion surgery by a trauma team * American Society of Anesthesiologists (ASA) Classification I-III * Willing and able to provide written informed consent to participate in the study. Exclusion Criteria: * History of chronic use of strong or weak opioids for more than 3 months. * Diagnosis of chronic pain and treatment by a pain management team. * ASA score greater than or equal to 4. * Patients with prior lumbar spine surgery. Spinal instrumentation at the surgical site. * Estimated creatinine clearance less than 60 ml/min. * Coagulation disorder or abnormal coagulation tests. * Infection at the surgical site. * Weight less than 50 kg. * Altered mental status that prevents reliable evaluation. * Allergy to local anesthetics or analgesic drugs used in the study. * Patients with contraindications to peripheral nerve blocks. * Lumbar spine fixation due to oncologic disease or acute trauma. * Use of intraoperative neuromonitoring and TIVA.

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Conditions

The condition(s) this trial relates to.

Acute Pain ankylosis lumbar disk disease vertebral column disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute pain Anesthesia Lumbar spine disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital Clínico Pontificia Universidad Católica de Chile

    RECRUITING

    Santiago, Santiago Metropolitan, Chile

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