Pontificia Universidad Catolica De Chile

This trial tests whether a 12-week dietary intervention can improve gut health, reduce inflammation, and enhance quality of life in adults with ulcerative colitis who are in remission. Participants are randomly assigned to a Mediterranean diet, a Mediterranean diet combined with …

This study compares two ways of positioning patients with severe lung failure (ARDS) who are on a breathing machine: lying on the stomach for more than 48 hours straight versus 16 to 24 hours each day. The goal is to see which approach helps more people survive. About 780 adults …

This study tests a medical device called PIMUN to see if it can reduce the time preterm babies spend with low oxygen levels. About 20 infants born before 34 weeks who have apnea of prematurity will be randomly assigned to use the device for 48 hours or receive usual care. Researc…

This study tests whether taking a daily oil rich in linoleic acid (a type of omega-6 fat) for 8 weeks can improve insulin resistance in adults aged 20-60 who have this condition plus at least one other cardiometabolic risk factor (like abdominal obesity or high blood pressure). P…

This study tests whether adding live microalgae to a standard skin-regeneration scaffold helps deep wounds heal faster and with fewer infections. Twenty adults with full-thickness skin wounds will receive both the standard scaffold and the algae-enhanced version on different part…

Critically ill patients with a tracheostomy need a reliable test to show they can breathe through the nose and mouth before the tube is removed. The standard capping trial blocks the tube, but the tube itself narrows the airway and may make breathing seem harder than it will be a…

This study tests whether giving tuberculosis (TB) prevention drugs immediately to children and teens who live with someone with active TB can stop them from getting infected. About 647 participants aged 5 to 17 will be randomly assigned to receive either immediate treatment or st…

This study tests whether an ultrasound-guided retrolaminar block (a numbing injection near the spine) can lower the amount of opioids patients need after lumbar spine fusion surgery. Forty-four adults will be randomly assigned to receive either the active block or a sham injectio…

This study tests a new type of talk therapy that is personalized for each person's emotional, relationship, and self-image struggles. It is for adults with depression that also involves personality problems or past trauma. 150 people in Chile's public health system will get eithe…

Many people survive a stay in the intensive care unit but then face lasting problems with thinking, mood, and physical function, a group of conditions called post-intensive care syndrome. Researchers in Chile are following 400 adults who needed a ventilator for at least two days,…

This study looks at how giving dexamethasone (a steroid) with a nerve block affects the amount of the numbing drug bupivacaine in the blood. Forty patients having shoulder surgery will receive the nerve block, with dexamethasone given either near the nerve or into a vein. Researc…

This study aims to create a new way to give propofol, a common anesthesia drug, to adults over 65. Researchers will monitor brain activity (EEG) and consciousness levels in 36 older adults during surgery to build a model that predicts the right dose. The goal is to improve safety…

This study tests whether remote, recorded feedback can teach medical students an ultrasound-guided nerve block as effectively as having an instructor present. Forty students practice the procedure on a simulator and receive either direct in-person guidance or feedback through a v…

This small study tests whether using immersive virtual reality (IVR) can reduce the effort it takes to breathe while exercising. Ten healthy adults will cycle with and without a VR headset, and their breathing effort will be measured with a thin tube in the esophagus. The goal is…

This study tests an artificial intelligence system called SEASCAPE that helps doctors manage pain during surgery. The AI monitors patient data in real time and suggests the best dose of a painkiller (remifentanil) to avoid giving too much or too little. 150 adults having planned …

This study looks at how changing the pressure inside the lungs (called PEEP) affects how hard patients have to work to breathe while on a ventilator. Twelve adults in the ICU who are already breathing with some help from a machine will have their PEEP set to four different levels…