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New nerve block may cut opioid use after gallbladder surgery

NCT ID NCT06768593

Symptom relief Sponsor: Istanbul Medipol University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study tested whether an ultrasound-guided nerve block called RIFP can reduce pain and the need for rescue painkillers after laparoscopic gallbladder removal. 77 patients were enrolled. The block targets nerves in the upper abdomen to provide pain relief. The main goal was to see if it lowers opioid use in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
RIFP block (a nerve block using local anesthetic)
What this could lead to
If effective, this nerve block could become a standard way to manage pain after gallbladder surgery, reducing the need for strong painkillers.
What could go wrong
This is a small, completed trial with no phase designation, so results may not apply to all patients. The block may not significantly reduce pain or opioid use compared to standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

77 people

The number who actually took part.

Started

Jan 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * American Society of Anesthesiologists (ASA) classification I-II patients * Laparoscopic cholecystectomy operation under general anesthesia Exclusion Criteria: patients with * with a history of bleeding diathesis * v receiving anticoagulant treatment, * with allergies or sensitivity to drugs used, * with an infection on the puncture site * with a history of alcohol or drug addiction, * with congestive heart failure * with liver or kidney disease * who do not accept the procedure or participate in the study

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Conditions

The condition(s) this trial relates to.

Acute Pain agnosia Bites and Stings

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute pain Laparoscopic cholecystectomy Pain management Plane block

Contacts and locations

Locations

  • Istanbul Medipol University Mega Hospital Complex

    Istanbul, Bagcilar, 34212, Turkey (Türkiye)

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