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Could magnesium replace opioids for trauma ICU pain?

NCT ID NCT04166877

Symptom relief Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a continuous intravenous infusion of magnesium sulfate can reduce pain and the need for narcotic painkillers in critically ill trauma patients admitted to the intensive care unit. Researchers will compare magnesium to a placebo (normal saline) in 156 adults aged 18-99. The goal is to find a safer, non-addictive option for pain management in the ICU.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
magnesium sulfate (a mineral given intravenously)
What this could lead to
If it works, this could offer a non-narcotic way to manage pain in trauma ICU patients, potentially reducing opioid use and side effects.
What could go wrong
This is a Phase 4 trial with 156 participants, so results may not apply to all trauma patients. Magnesium can cause side effects like slow heart rate or breathing problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 156 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2019

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All trauma patients admitted to an adult intensive care unit * Signed informed consent * Hospital or trauma multimodal pain management order set used for pain management * Ages 18-99 Exclusion Criteria: * Admission to the Pediatric Intensive Care Unit. * Head Abbreviated Injury Score (AIS) of greater than 1 * Known heart failure with reduced ejection fraction (EF \< 40%) * Renal failure (GFR \< 60) * Cardiac arrhythmia (except for sinus tachycardia) * Greater than 5% TBSA burn injuries * Moderate to severe alcohol withdrawal protocol ordered for patient * Regular use of opioids in the week prior to injury * Receiving continuous infusion of opioids * Patients expected to require general anesthesia between 24 and 48 hours after admission (during study drug administration) * Patients unable to provide consent is unavailable * Patients unable to provide a pain score * Pregnancy * Prisoners

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Conditions

The condition(s) this trial relates to.

Acute Pain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute pain Trauma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UC Davis Health

    RECRUITING

    Sacramento, California, 95817, United States

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