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New rinse may ease root canal pain better than standard

NCT ID NCT07173725

Symptom relief Sponsor: Bezmialem Vakif University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether a rinse called octenidine reduces pain after root canal treatment better than the standard rinse chlorhexidine. 142 adults with a single-rooted tooth and asymptomatic apical periodontitis received one of the two rinses during their procedure. Pain was recorded at 6, 12, 24, and 48 hours after treatment. The goal was to see if octenidine leads to less early pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Octenidine dihydrochloride 0.1% solution
What this could lead to
If octenidine works better, it could offer a new option to reduce pain after root canal treatment.
What could go wrong
This is a small, completed trial comparing two rinses, not a new treatment. Results may not apply to all teeth or pain types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

142 people

The number who actually took part.

Started

Mar 2023

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 65 years (inclusive) * Single-rooted, single-canal tooth * Diagnosis of asymptomatic apical periodontitis on periapical radiographs * Able and willing to provide written informed consent * Able to complete a 48-hour pain diary (6 h, 12 h, 24 h, 48 h) Exclusion Criteria: * Symptomatic apical periodontitis or acute apical abscess * Previous root canal treatment of the study tooth * Systemic condition requiring antibiotic prophylaxis or that interferes with pain assessment * Pregnancy or lactation * Known allergy or contraindication to study irrigants/materials * Use of analgesics or anti-inflammatory drugs within 12 hours before treatment * Inability to comply with study procedures * More than one eligible tooth (one patient = one tooth rule; a pre-specified index tooth is selected)

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis Postoperative pain

Contacts and locations

Locations

  • Bezmialem Vakif University Dental Hospital - Department of Endodontics

    Istanbul, 34093, Turkey (Türkiye)

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