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New pain block combo may cut opioid use after heart surgery

NCT ID NCT04908449

Symptom relief Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding a second nerve block (rectus sheath block) to a standard chest wall block (pectointercostal fascial plane block) improves pain control after heart surgery. 62 adults having elective heart surgery through a breastbone incision were randomly assigned to receive either the standard block alone or the standard block plus the extra block. The goal was to see if the combination reduces pain scores, lowers opioid painkiller use, and improves breathing recovery in the first 24-48 hours after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

62 people

The number who actually took part.

Started

Jun 2023

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects scheduled for cardiac surgery involving primary median sternotomy and mediastinal chest tubes. * Age 18-85 years of age * BMI 18-50 kg/m2 * Weight \> 60 kg Exclusion Criteria: * Left ventricular ejection fraction (LVEF) \< 30% * Preoperative, intraoperative, or immediate post-operative placement of intra-aortic balloon pump or deployment of extra-corporeal membrane oxygenation (ECMO) * Inability to understand or speak English * Allergy to bupivacaine or other amide local anesthetic * Contraindication to peripheral nerve block (e.g. local infection, previous trauma to the block site) * Chronic opioid consumption (daily oral morphine equivalent of \>20 mg) in the past three months * Severe pulmonary or hepatic disease * Neurological deficit or disorder * Suspected or known addiction to or abuse of illicit drug(s), prescription medicine(s), or alcohol within the past two years * Uncontrolled anxiety, schizophrenia, or other severe psychiatric disorder

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Conditions

The condition(s) this trial relates to.

coronary artery disorder Pain, Postoperative respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery disease Postoperative pain Respiratory failure

Contacts and locations

Locations

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.