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New pain block could cut opioid use after liver transplant

NCT ID NCT07233083

Symptom relief Sponsor: Istinye University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a nerve block called the external oblique intercostal plane block can reduce pain after liver transplant surgery. Sixty-four adult patients received either the block or a sham procedure after surgery. Researchers measured how much morphine patients needed and their pain scores over the first 24 hours.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
external oblique intercostal plane block (a nerve block injection)
What this could lead to
If it works, this could offer a better way to manage pain after liver transplant, possibly reducing the need for strong opioids.
What could go wrong
This is a small, completed trial with only 64 participants. The block may not provide significant pain relief over a sham procedure, and results may not apply to all transplant patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

64 people

The number who actually took part.

Started

Dec 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged 18 to 75 years * Scheduled for elective orthotopic liver transplantation (living or deceased donor) * J-shaped or Mercedes incision planned * ASA physical status III-IV * Normal or acceptable coagulation profile at the time of block application (INR ≤ 1.5, platelet count ≥ 50,000/mm³, fibrinogen ≥ 150 mg/dL) * Able to provide written informed consent Exclusion Criteria: * Coagulopathy at the time of block application (INR \> 1.5, platelet count \< 50,000/mm³, or fibrinogen \< 150 mg/dL) * Known allergy or hypersensitivity to local anesthetics (amide group) * Local infection or skin lesion at the block injection site * Severe hemodynamic instability requiring high-dose vasopressor support * Chronic opioid use (≥30 mg oral morphine equivalents per day for ≥30 days before surgery) * Severe hepatic encephalopathy or cognitive impairment preventing use of PCA or pain scoring * Emergency or re-transplantation surgery

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Conditions

The condition(s) this trial relates to.

chronic liver failure Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Liver transplantation Postoperative pain Recipients of liver transplant

Contacts and locations

Locations

  • istinye University

    Istanbul, Turkey (Türkiye)

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