LIVER TRANSPLANTATION

This large study is testing if a drug called tranexamic acid (TXA) can safely reduce dangerous bleeding during liver transplant surgery. Over 1,500 adult patients receiving a liver transplant will be randomly given either TXA or a placebo (saltwater) during their operation. The m…

This study is testing whether following a structured Mediterranean diet can help people who have received a liver transplant. Researchers want to see if this diet prevents unhealthy weight gain, improves heart health, and reduces the risk of developing fatty liver disease. The st…

This study is testing whether giving albumin (a natural blood protein) to liver transplant patients can help prevent kidney damage after surgery. Researchers will compare two groups: one receiving enough albumin to maintain normal blood levels for five days, and another receiving…

This study is testing a machine that keeps donated livers functioning outside the body, allowing doctors to assess their quality. The goal is to see if this process can safely increase the number of livers available for transplant, helping more patients get a transplant sooner. R…

This study is testing whether specialized addiction support after a liver transplant helps patients stay away from alcohol. It will involve 720 people who received a transplant due to alcohol-related liver disease. Half will receive standard follow-up care, while the other half w…

This study tests a new approach to help people who received a liver transplant from a living donor safely stop taking lifelong anti-rejection drugs. These drugs prevent organ rejection but have serious side effects. Researchers will use a short course of radiation and medication,…

This study is testing two different approaches to managing fluids given during liver transplant surgery. One approach uses less fluid overall, while the other uses more fluid to keep the heart pumping strongly. The goal is to see which method helps patients recover better after s…

This study is testing if taking all anti-rejection drugs once a day is as safe and effective as taking them twice a day for people who have received a liver transplant. The goal is to make the lifelong medication routine easier to follow, which could help patients stick to their …

This international study is testing if a new machine treatment for donor livers can help prevent liver cancer from coming back after a transplant. The machine, called HOPE, pumps a cold, oxygen-rich fluid through the liver before surgery. Researchers will compare this method to t…

This study is testing a new bedside device called Quantra to help doctors better manage bleeding during liver transplant surgery. It compares the new device's guidance for blood transfusions against the standard approach. The goal is to see if using Quantra can reduce the amount …

This study is testing a new pain-relief technique for people who donate part of their liver. It compares a targeted nerve-block injection to standard pain medication after surgery. The goal is to see if the new method reduces overall pain and the need for strong opioid painkiller…

This study is testing if giving the drugs methadone and ketamine during a liver transplant from a deceased donor can help reduce pain and mental confusion after the surgery. Researchers will compare this combination to the standard pain medications currently used. The goal is to …

This study is testing whether a specific nerve block, given at the end of liver transplant surgery, helps control pain better during recovery. Researchers will compare 60 patients who receive the block to those who do not, measuring how much strong pain medication they need and t…

This study aims to understand how a person's physical strength, nutrition, and mental health before a liver transplant affect their recovery afterward. Researchers will measure frailty, muscle mass, and psychological well-being in 60 adults waiting for a transplant. The goal is t…

This study aims to understand why kidney problems develop in some people after a liver transplant. Researchers will follow 369 patients who already have signs of kidney damage and have had a kidney biopsy. Over two years, they will track how kidney health changes and try to ident…