LIVER TRANSPLANTATION

This study tests a bedside device called Quantra that measures blood clotting in real time during liver transplant surgery. The goal is to see if using Quantra to guide transfusions can reduce bleeding and the need for blood products compared to standard methods. About 56 adults …

This study tests whether giving immunosuppressive drugs as a single daily dose after liver transplant works as well as the standard twice-daily regimen. About 162 liver transplant recipients will be randomly assigned to once-daily or twice-daily dosing. The goal is to see if once…

This study compares two medications, terlipressin and somatostatin, to see which one better lowers high blood pressure in the liver's main vein during a living-donor liver transplant. High pressure there can cause more bleeding during surgery. About 50 adults with severe liver di…

This study tests whether a structured Mediterranean diet can prevent weight gain, improve heart health, and stop fatty liver disease in people who have had a liver transplant. About 80 adults with a higher body weight before transplant will follow the diet for a period. The goal …

This study tests whether giving a protein called albumin after a liver transplant can lower the risk of acute kidney injury. About 400 adult liver transplant recipients will be split into two groups: one gets enough albumin to keep blood levels above 30 g/L for five days, while t…

This study tests whether tranexamic acid, a drug that helps blood clot, can reduce blood loss during liver transplant surgery without causing dangerous clots. About 1,546 adults receiving a new liver will be randomly given either the drug or a placebo. The goal is to see if the d…

This study tests a method called normothermic machine perfusion, which keeps donated livers working outside the body so doctors can check their quality. The goal is to safely use livers that were previously considered unsuitable, helping 186 adults on the transplant waiting list …

This study tests whether a one-time infusion of donor stem cells, combined with low-dose radiation and immune therapy, can retrain the immune system to accept a liver transplant without lifelong anti-rejection drugs. The goal is to safely wean 12 adult liver transplant recipients…

This study tests whether adding addiction monitoring after a liver transplant can reduce the rate of alcohol relapse. About 720 adults who received a liver transplant due to alcohol-related liver disease will be followed for two years. The goal is to see if this extra support hel…

This study tests whether treating donor livers with a special oxygen-rich cold fluid (HOPE) before transplant can help prevent liver cancer from coming back. About 220 adults with liver cancer and cirrhosis who are waiting for a liver transplant will take part. Half of the donate…

This study tests whether a special nerve block (RIFP block) can reduce pain and the need for morphine in people who donate part of their liver. 64 donors will either get the block plus standard pain relief, or standard pain relief alone. The goal is to see if the block helps them…

This study looks at whether a specific nerve block (external oblique intercostal plane block) can better control pain after liver transplant surgery. Sixty adults getting a liver transplant will be split into two groups: one gets the nerve block plus standard care, the other gets…

This study looks at two different ways of managing fluids during liver transplant surgery. One method uses less fluid and removes some blood before re-giving it later, while the other gives more fluid to keep the heart pumping well. The goal is to see which approach helps patient…

This study follows 369 liver transplant patients who have new or worsening kidney problems. Researchers perform kidney biopsies to understand the cause of kidney damage and track how kidney function changes over time. The goal is to identify risk factors that lead to kidney failu…

This study looks at how frailty, nutrition, muscle loss, and mental health affect people waiting for a liver transplant. Researchers will measure physical strength, walking ability, and daily function, along with diet and emotional well-being. The goal is to see which factors pre…