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Machine perfusion could double usable donor livers and cut wait times

NCT ID NCT06874296

Disease control Sponsor: Charite University, Berlin, Germany Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a machine that keeps donated livers working outside the body can help doctors safely use livers that were previously considered too risky for transplant. About 186 adults on the liver transplant waiting list will be randomly assigned to either receive a standard transplant or be offered a liver that passed a quality check after at least four hours on the machine. The main goal is to see if this approach shortens the time to transplant and increases the number of usable livers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 186 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Able to consent * ≥ 18 years old * Listed in status "transplantable" by the transplant conference of the study centre for liver transplantation, according to the guidelines of the German Medical Association valid at the time of inclusion * ReMELD-Na-Score ≤ 21 (equivalent to MELD ≤25), not eligible for \[non\]standard exceptions * Medically suitable and informed for transplantation with an organ that fulfils extended donor criteria (Eurotransplant ECD criteria) * Patient information and written consent to participate in the Extra trial * No participation in another interventional study during participation Exclusion Criteria: * Listed for retransplantation * High-Urgency Listing * Listed for combined organ transplantation * Pregnancy

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Conditions

The condition(s) this trial relates to.

liver disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Liver diseases Liver transplantation Surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    10 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of General, Visceral and Transplant Surgery, Hannover Medical School

    RECRUITING

    Hanover, Germany

  • Department of General, Visceral and Transplantation Surgery, LMU University Hospital, LMU Munich

    RECRUITING

    München, Germany

  • Department of General, Visceral, Transplantation, Vascular, and Pediatric Surgery, University Hospital Wurzburg

    RECRUITING

    Würzburg, Germany

  • Department of Surgery Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin

    RECRUITING

    Berlin, State of Berlin, 13353, Germany

  • Department of Surgery, University Hospital Regensburg

    RECRUITING

    Regensburg, Germany

  • Eberhard Karls University of Tübingen, Department of General Visceral and Transplant Surgery

    RECRUITING

    Tübingen, Germany

  • University Hospital Bonn

    RECRUITING

    Bonn, North Rhine-Westphalia, 53127, Germany

  • University Hospital Muenster

    RECRUITING

    Münster, North Rhine-Westphalia, 49149, Germany

  • University Hospital RWTH Aachen

    RECRUITING

    Aachen, North Rhine-Westphalia, 52074, Germany

  • University Medical Center Hamburg-Eppendorf

    RECRUITING

    Hamburg, Free and Hanseatic City of Hamburg, 20251, Germany

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Other studies related to the condition(s) this trial covers.