Charite University, Berlin, Germany

This international study aims to improve treatment for children and adolescents whose acute lymphoblastic leukemia (ALL) has returned and is considered high-risk. Researchers are testing whether adding the drug bortezomib to standard chemotherapy helps more patients achieve a sec…

This is a first-in-human safety study for a new type of heart valve replacement. It tests a valve made from a patient's own tissue, designed to be more durable and potentially adapt over time. The study will enroll 7 adults with a severely leaky pulmonary valve to see if the impl…

This study is testing a machine that keeps donated livers functioning outside the body, allowing doctors to assess their quality. The goal is to see if this process can safely increase the number of livers available for transplant, helping more patients get a transplant sooner. R…

This study is testing whether modern heart failure medications alone are as effective as adding an implanted defibrillator (ICD) for preventing sudden death in heart attack survivors with weakened hearts. It will enroll over 3,500 people who have had a heart attack and now have h…

This study is testing whether adding gentle, non-invasive brain stimulation to a mindfulness-based relapse prevention program helps people with alcohol dependence stay sober better than the mindfulness program alone. It will involve 140 people who have recently stopped drinking. …

This study aims to create a computer program (AI) that can quickly identify sepsis by analyzing existing hospital patient records. Researchers will look at data from 10,000 adult patients who spent time in intensive care. The goal is to see if this AI tool can help doctors diagno…

This study aims to find the best way to identify psoriatic arthritis early in people who have psoriasis. It will compare two methods: a standard patient questionnaire versus that same questionnaire plus a brief joint check by a dermatologist. The goal is to see which approach mor…

This study is testing a 12-week personalized digital exercise program for people who recently had knee ligament (ACL) surgery. The goal is to teach better movement patterns to reduce joint inflammation and prevent the development of osteoarthritis. Researchers will use motion sen…

This study aims to prevent delirium, a serious state of confusion, in older patients after surgery. It tests a comprehensive hospital program that includes regular screening and proven preventive measures. The research involves 18,100 patients aged 70 and older in Germany to see …

This study is testing a digital support system designed to help hospital staff follow established guidelines to prevent postoperative delirium, a common and serious confusion state after surgery. It will involve 800 patients aged 70 and older having elective surgery. The main goa…

This study aims to improve how children with congenital heart disease are prepared for surgery or catheter procedures to reduce their stress and anxiety beforehand. Researchers will assess 200 children at a Berlin hospital, using questionnaires to measure anxiety levels before th…

This study is testing whether a nasal spray containing oxytocin, a hormone linked to social bonding, can make group mindfulness therapy more effective for people with schizophrenia. Researchers want to see if taking oxytocin before weekly therapy sessions helps reduce hard-to-tre…

This study is observing 2500 patients with chronic diseases who are receiving inpatient treatment that combines traditional and complementary medicine (TCIM) approaches at three German hospitals. The goal is to measure how these treatments—which include heat therapy, exercise, mi…

This study is testing whether a gentle, non-invasive brain stimulation technique can reduce the severe fatigue that many people with multiple sclerosis experience. Researchers will compare the effects of real stimulation versus a sham (fake) treatment on 84 participants over seve…

This study is testing whether special dynamic lighting can help stabilize the natural sleep-wake cycles of patients experiencing delirium in intensive care. Researchers will compare this light therapy against standard hospital lighting in 40 ICU patients to see if it reduces deli…

This study is testing whether a new smartphone app called Kiso Mind is practical and helpful for people living with schizophrenia or schizoaffective disorder. About 60 participants will either use the app alongside their usual care or receive only their usual care for 12 weeks. R…

This study is testing whether two different acupuncture approaches can help women with multiple sclerosis who have bladder control problems. Researchers will compare mild electrical stimulation, manual pressure techniques, and standard care alone in 150 participants. The goal is …

This pilot study is testing whether a yoga-based group program can help outpatients with schizophrenia spectrum disorders. It will compare the yoga program to a standard exercise group and to usual psychiatric care alone. The main goals are to see if the program is practical and …

This study is testing whether adding specialized palliative care consultations in intensive care units (ICUs) can reduce suffering for seriously ill patients. It will involve over 2,000 patients across multiple hospitals, comparing outcomes when palliative care experts are involv…

This study aims to understand how much protein cancer patients eat during and after radiotherapy, and how it affects their muscle mass and quality of life. Researchers will observe 175 patients with various cancers, tracking their diet, weight, and muscle measurements. The goal i…

This study aims to see if a simple change in eating schedule can improve the body's immune response to vaccines in older adults. Healthy volunteers aged 60-85 will follow either their normal eating pattern or a time-restricted schedule (eating within an 8-hour window) for four we…

This study is testing whether a single dose of the hormone estradiol can reduce the formation of intrusive, unwanted memories after a stressful experience. Healthy female volunteers will watch a distressing film and then track any intrusive memories for four days, comparing those…

This study aims to understand why patients who have been in intensive care do or don't attend their follow-up appointments at a special recovery clinic. Researchers will look at medical records of 2,500 patients to identify factors that influence attendance. The goal is to find w…

This study is testing if a specific adjustment to a breathing machine's pressure settings can help children in two situations: after heart surgery using a heart-lung bypass machine, and in children with severe breathing failure who might need advanced life support. Researchers wa…

This study is collecting and analyzing existing data to better understand how often surgery leads to problems with memory, thinking, and concentration, known as postoperative cognitive dysfunction. It will involve up to 5,000 adults who have had surgery, comparing them to people …

This study aims to learn how to better adjust deep brain stimulation (DBS) therapy for people with dystonia, a severe movement disorder. Researchers will monitor patients' brain signals for one year using a special pacemaker that can also record activity. The goal is to find patt…

This study aims to understand the experiences, needs, and wishes of prostate cancer patients and their close family members during and after radiation therapy. Researchers will conduct interviews to learn what support would be most helpful. The goal is to use this information to …

This study aims to improve the safety and quality of care for surgery and intensive care patients. Researchers will analyze the electronic health records of up to one million past patients to find hidden patterns in their data—like combinations of vital signs and lab results—that…

This study is a registry that will track 200 patients in Berlin who have had a minimally invasive procedure to fix leaky or narrowed valves on the right side of their heart. The goal is to observe and compare how different procedures affect patients' survival, need for hospital s…

This study aims to understand how approved cystic fibrosis (CF) modulator treatments affect the body's biological markers and patient health in real-world use. It will follow 500 people with CF in Germany for one year, measuring changes in sweat, intestinal function, lung health,…

This study aims to understand the long-term recovery challenges faced by patients who survived severe COVID-19 requiring intensive care. Researchers are comparing about 13 pregnant patients with about 27 non-pregnant patients to see if pregnancy affects recovery in areas like phy…

This study aims to understand how brain function changes over 7-10 years in people who participated in a previous research project. Researchers are contacting 434 former participants to complete online memory and thinking tests from home, along with questionnaires about daily lif…

This study aims to understand why some patients with severe lung failure (ARDS) develop additional infections while in the hospital. Researchers will look back at the medical records of 200 patients to see if their immune system status when they were admitted is linked to these c…