New breathing technique could help ventilated kids breathe easier
NCT ID NCT07193719
First seen Nov 01, 2025 · Last updated Jun 19, 2026 · Updated 36 times
Summary
This study tests whether a personalized lung volume optimization maneuver can improve heart and lung function in children on mechanical ventilators. It includes two groups: children recovering from heart surgery and those with severe respiratory failure at risk for ECMO. Researchers will adjust ventilator pressure to find the best settings for each child, then measure effects on cardiac output, lung compliance, and other outcomes.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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German Heart Center of the Charité
RECRUITINGBerlin, 13353, Germany
Contact Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lung volume optimization maneuver (PEEP titration)
What this could lead to
If successful, this could lead to a standardized method to improve breathing and heart function in critically ill children, potentially reducing time on a ventilator or ECMO.
What could go wrong
This is an early-phase study with only 80 participants, so results may not apply to all children. The maneuver involves adjusting ventilator pressure, which could affect heart function in some cases.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.