CARDIAC SURGERY

This study is a pilot test to see if a future large trial is possible. It compares two ways of storing platelets, a blood component that helps with clotting, before giving them to adult heart surgery patients who are bleeding. The goal is to see if platelets stored cold work as w…

This study is testing whether a digital platform based on Enhanced Recovery After Surgery (ERAS) principles can help patients recover more quickly after heart bypass surgery. It will involve 480 adults in Brazil who are scheduled for this surgery and have a smartphone. The main g…

This study is testing whether a special anesthesia plan focused on protecting the brain can reduce hidden strokes and thinking problems after heart surgery. Researchers will compare this new plan to standard care in over 900 older adults having planned heart surgery. The goal is …

This is the first human study testing the safety of a new medical device called the iPerf cannula. The device is designed to protect blood flow to the leg during certain heart surgeries that use the femoral artery. The study will enroll 15 adult patients in France to monitor for …

This study is testing whether giving intravenous iron to patients with iron deficiency after heart surgery helps them recover better. It will involve 60 patients across three Canadian hospitals who will receive either the iron treatment or a placebo. The main goal is to see if th…

This study is testing new plastic tubes used to connect patients to a heart-lung bypass machine during certain heart surgeries. The goal is to see if these new tubes are as safe and work as well as the tubes doctors already use. The study will involve 80 adults having planned hea…

This study is testing if using a bedside urine sensor to guide a common water pill (furosemide) is better than the usual approach for managing fluid overload after heart surgery. Researchers will compare how well the sensor-guided method removes excess fluid and whether it leads …

This large study aims to find out if using the inhaled anesthetic desflurane is better than the intravenous drug propofol at protecting the heart during bypass surgery. It will enroll over 3,500 adults having planned heart bypass operations. The main goal is to see which method l…

This study is testing if a smartwatch can find a dangerous irregular heartbeat that often happens silently after heart surgery. About 324 patients who just had heart surgery will be randomly assigned to either use a smartwatch for monitoring or receive the hospital's usual care. …

This study is testing whether medical trainees can learn to use a bedside ultrasound device to detect a collapsed lung after heart surgery. After patients have their chest tubes removed, a trainee will perform an ultrasound while the patient also gets the standard chest X-ray. Th…

This study is testing whether an experimental drug called LSALT peptide can prevent or lessen kidney injury in patients having major heart surgery using a heart-lung machine. About 240 adult patients at higher risk for kidney problems will receive either the drug or a placebo (sa…

This study aims to see which of two newer nerve-block techniques works better for pain control after open-heart surgery. Researchers will compare the Transversus Thoracic Muscle Plane Block (TTPB) and the Pectointercostal Fascial Block (PIFB) in 90 patients. The goal is to reduce…

This study is testing whether a new type of nerve block, injected near the shoulder blade, can better manage pain and reduce the need for strong opioid painkillers in the first day after open-heart surgery. Researchers will compare pain levels and medication use in 50 patients wh…

This study is testing if a local anesthetic (ropivacaine) delivered directly into the chest cavity through drainage tubes can improve recovery and reduce pain after major heart surgery. It compares this method against a placebo in 116 patients. The goal is to see if this targeted…

This study is testing if giving methadone as a pill before surgery works as well as giving it through an IV during surgery to control pain afterward. It involves 100 adults having planned heart surgery. The main goal is to see which method better reduces the need for strong paink…

This study compares two different nerve-blocking techniques to manage pain after heart surgery through the breastbone. Researchers will test which method provides better pain relief and recovery for 50 patients undergoing this type of surgery. The goal is to improve comfort and r…

This study aims to understand why many older adults experience memory and thinking problems after heart surgery. Researchers will follow 50 patients aged 60+ to see if simple blood tests or short thinking assessments can predict or detect these issues. The goal is to find better …

This study is testing if a specific adjustment to a breathing machine's pressure settings can help children in two situations: after heart surgery using a heart-lung bypass machine, and in children with severe breathing failure who might need advanced life support. Researchers wa…

This study aims to understand how common and serious irregular heartbeats are after heart surgery. Researchers will monitor 150 heart surgery patients using a wearable heart monitor patch to track heart rhythms. The goal is to identify which patients are most at risk and measure …

This study aims to understand if congestion in the body's veins during heart surgery is linked to confusion (delirium) afterward. Researchers will observe 120 adults having elective heart surgery, measuring their blood flow during the operation and checking for signs of confusion…

This study is testing whether patients who have had heart surgery can safely and effectively swab their own chest wounds at home to check for infections. Researchers want to see if home swabbing provides good quality samples for lab testing and if patients find the process accept…

This study aims to understand how often and why it's difficult to place a breathing tube in patients undergoing heart surgery. Researchers will collect data from 2000 adult patients to identify risk factors and develop a computer model (using artificial intelligence) to predict t…

This study aims to understand how drops in blood pressure during heart surgery affect patients' recovery. Researchers will follow 230 adults having planned heart surgery to see if low blood pressure during the operation leads to serious complications like kidney problems, confusi…