CARDIAC SURGERY

This study tests whether giving iron through a vein (IV) after heart surgery helps people with iron-deficiency anemia recover better. About 60 adults having planned open heart surgery will receive either IV iron or a placebo. The goal is to see if this treatment helps them spend …

This study tests new plastic tubes (cannulas) used to connect patients to a heart-lung machine during heart surgery. The goal is to see if they are safe and work as well as current tubes. About 80 adults having planned heart surgery will take part. The study has two phases: first…

This study tests whether a targeted anesthesia approach called NeuroFirst can lower the risk of silent brain damage and memory or thinking problems after heart surgery. About 912 adults aged 60 and older having elective heart surgery will be randomly assigned to receive either Ne…

This study looks at whether giving iron supplements to anemic patients before major heart surgery can improve their long-term quality of life, sleep, and fatigue. About 400 adults with iron-deficiency anemia scheduled for heart surgery will be randomly assigned to receive iron or…

This early study tests a new tube (cannula) designed to keep blood flowing to the leg during heart surgery that uses a heart-lung machine. The device is placed in the leg artery and aims to reduce the risk of leg complications. The study will include 15 adults and will monitor sa…

This study tests whether the inhaled anesthetic desflurane is better than propofol at preventing major heart events like death, heart failure, or heart attack in adults undergoing coronary artery bypass surgery. About 3,560 participants will be randomly assigned to receive one of…

This study tests whether using a simple urine test to guide diuretic dosing can improve fluid removal after heart surgery. About 102 adults having heart surgery will be randomly assigned to standard care or a urine-sodium-guided approach. The goal is to see if this method safely …

This study tests whether cold-stored platelets work as well as standard room temperature-stored platelets to control bleeding in adults having heart surgery. About 150 participants will be randomly assigned to receive one type of platelet transfusion. The goal is to see if a larg…

This study tests whether a smartwatch can find irregular heartbeats (atrial fibrillation) that often go unnoticed after heart surgery. About 324 adults who had heart surgery will either use a smartwatch or receive standard care. The goal is to see if the watch helps doctors catch…

This study tests whether the drug LSALT peptide can prevent or reduce acute kidney injury in 240 adults having heart surgery that uses a heart-lung machine. Participants receive either the drug or a placebo before surgery, and doctors monitor kidney function for a week. The goal …

This study tests whether giving a numbing medicine (ropivacaine) through chest tubes placed after heart surgery helps patients recover better and feel less pain. About 116 adults having planned heart surgery will receive either the medicine or a placebo. The main goal is to see i…

This study tests if a special nerve block (SPSIP block) can reduce pain and the need for strong painkillers after open-heart surgery. About 50 adults having planned heart surgery will receive either the block plus standard care or standard care alone. Researchers will measure pai…

This study tests two types of nerve blocks (TTPB and PIFB) to see which one better controls pain after open-heart surgery. About 90 adults aged 40-60 having coronary bypass will receive one of the blocks. The goal is to reduce pain and the need for extra painkillers, helping pati…

This study tests whether giving methadone as a pill before heart surgery works better than giving it through an IV during surgery to control pain afterward. About 100 adults having planned heart surgery will take part. Researchers will measure how much additional pain medicine pa…

This study compares two types of nerve blocks to manage pain after heart surgery through the breastbone. About 50 adults will receive either one block or a combination of two blocks. The goal is to find which method provides better pain relief and reduces the need for strong pain…

This study tracks 150 adults having planned open-heart surgery to see how often atrial fibrillation (AF) occurs afterward. Participants wear a small EKG patch to record heart rhythms, and researchers will look for patterns and risk factors. The goal is to better understand AF's t…

This study tests whether a personalized lung inflation technique can improve heart and lung function in two groups of children on breathing machines: those recovering from heart surgery and those with severe respiratory failure. Researchers will measure how well the lungs and hea…

This study looks at whether a backup of blood in the veins during heart surgery is linked to confusion (delirium) after the operation. Researchers will monitor 120 adults having planned heart surgery, checking for vein congestion during the procedure and testing for delirium dail…

This study explores whether medical trainees (residents and fellows) can learn to use lung ultrasound to detect a collapsed lung (pneumothorax) after heart surgery. About 120 adults who had heart surgery and are having chest tubes removed will get both a trainee-performed ultraso…

This study is for adults having heart surgery. It will track how often doctors have trouble placing a breathing tube (a difficult airway) and why. The goal is to create a tool that helps predict these problems before surgery, making the procedure safer. 2000 participants will be …

This study tests whether a technology platform based on Enhanced Recovery After Surgery (ERAS) can shorten hospital stays for adults undergoing coronary artery bypass grafting. About 480 participants across multiple centers in Brazil will use the platform, which provides recovery…

This study compares two modern anesthesia approaches for heart surgery: Fast Track and Ultra Fast Track. The goal is to see which method leads to fewer complications, like lung problems or confusion, and helps patients wake up and leave the hospital sooner. About 50 adults having…

This study watches 160 adults having planned heart surgery to see if taking more than one blood pressure medicine leads to dangerous drops in blood pressure right after anesthesia starts. Researchers will measure how low and how long blood pressure falls, and how much extra medic…

This study looks at whether people who have had heart surgery can safely and effectively collect a swab from their chest wound at home. About 40 adults will try self-swabbing using a special kit and video guidance. The goal is to see if this approach is acceptable, safe, and coul…

This study looks at why some older adults experience memory and thinking problems after heart surgery. Researchers will test 80 patients aged 60 and older using thinking assessments and blood tests to measure brain inflammation. The goal is to find simple ways to identify those a…

This study tracks 230 adults having planned heart surgery to see if drops in blood pressure during the operation lead to serious problems like confusion, kidney damage, stroke, or death within 30 days. Researchers will monitor blood pressure and use of medicines to raise it, then…