Heart surgery brain shield: new strategy aims to prevent silent strokes
NCT ID NCT07048002
First seen Jan 11, 2026 · Last updated Jun 23, 2026 · Updated 24 times
Summary
This study tests whether a set of anesthesia goals, called NeuroFirst, can reduce silent brain damage and thinking problems after heart surgery. About 900 older adults having heart surgery will be randomly assigned to either the NeuroFirst plan or usual care. Researchers will use brain scans and thinking tests to compare outcomes up to one year later.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beijing Chaoyang Hospital，Capital Medical University
RECRUITINGBeijing, Beijing Municipality, 100020, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Beijing Tiantan Hospital, Capital Medical University
RECRUITINGBeijing, Beijing Municipality, 100160, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
RECRUITINGBeijing, Beijing Municipality, 100037, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology
RECRUITINGWuhan, Hubei, 430014, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Xuanwu Hospital,Capital Medical University
RECRUITINGBeijing, Beijing Municipality, 100053, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
NeuroFirst target bundle (a set of anesthesia management goals including blood pressure, brain activity, oxygen levels, and temperature control)
What this could lead to
If successful, this could provide a simple, low-cost way to protect the brain during heart surgery and reduce the risk of thinking and memory problems afterward.
What could go wrong
This is a single study testing a bundle of existing techniques, not a new drug. The benefits may be small or not apply to all patients, and the results need confirmation in larger, more diverse groups.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.