NEUROCOGNITIVE DISORDERS

This study tests whether a targeted anesthesia approach called NeuroFirst can lower the risk of silent brain damage and memory or thinking problems after heart surgery. About 912 adults aged 60 and older having elective heart surgery will be randomly assigned to receive either Ne…

This study looks at whether a healthy lifestyle can help thinking skills and liver health in adults with non-alcoholic fatty liver disease (NAFLD). 45 people aged 18-42 will be placed into one of three groups for six months: general health advice, a Mediterranean diet, or the sam…

This study tests whether a sedative called dexmedetomidine can prevent long-term memory and thinking problems that often occur after heart surgery. Researchers will enroll 2,400 adults aged 60 and older who are having bypass or valve surgery. Participants will receive either dexm…

This study is developing a computer algorithm that can detect early Alzheimer's disease by analyzing a person's voice and speech patterns. Researchers will compare speech recordings from 100 adults aged 50 and older with existing brain and spinal fluid tests. If successful, this …

This study compares two programs designed to prevent delirium (sudden confusion) in older adults during a hospital stay. One program uses hospital staff, while the other also involves family members or care partners. The goal is to see which approach works better to reduce confus…

This study tests whether a program of nutrition education, physical activity, and at-home cognitive training can help prevent memory decline in adults aged 55 to 85 who are at higher risk for dementia. Over 120 participants will follow a Mediterranean diet-focused plan and attend…

This small pilot study tests whether a non-invasive brain stimulation technique called rTMS can reduce apathy in people with dementia or mild cognitive impairment. Apathy—lack of interest or motivation—is common and disabling. The study includes 10 participants, some already taki…

This study tests a treatment that combines gentle, non-invasive brain stimulation with computer-based thinking exercises for people with mild cognitive impairment (MCI), a condition that can lead to memory and thinking problems. About 50 older adults (ages 60-85) will receive the…

This study tests if a liquid medicine called midazolam can help elderly patients with moderate to severe memory problems feel calmer and accept care they usually resist. About 30 hospitalized patients will receive the medicine before care routines. The goal is to reduce their res…

This study tests a device called ATNC MDD-V1 that combines magnetic brain stimulation with cognitive training to help people with mild Alzheimer's disease. Researchers want to see if it improves thinking and memory over 24 weeks. The study involves 180 adults aged 60-85 who are a…

This study looks at whether adding a physical activity education program to adapted exercise helps people with mild or early major neurocognitive disorders (like early dementia). About 34 participants will be split into two groups: one doing only adapted physical activity, the ot…

This study looks at how the walls of the carotid artery (the main artery in the neck) behave in people with different types of memory loss. Researchers will measure artery viscosity in 140 volunteers over age 70, comparing those with Alzheimer's disease, vascular dementia, and th…

This study uses ultrasound to measure tiny brain movements in 300 people with mild or major cognitive disorders. Researchers want to see if these movements differ between groups and can predict who will get worse over time. The goal is to better understand how cognitive decline p…

This study looks at how speaking two languages (Spanish and English or Spanish and Catalan) affects language treatment in people with primary progressive aphasia (PPA), a condition that first causes speech and language problems. Researchers will give tailored speech therapy in bo…

This study tests whether a supplement called nicotinamide riboside can affect brain energy and stress in people with mild memory problems or early Alzheimer's. Researchers will use home sensors to track sleep, movement, and walking speed over 12 weeks. The goal is to find new way…

This study follows about 225 children whose mothers had type 1 diabetes during pregnancy. Researchers will check the kids' thinking skills and look for links to autism. The goal is to learn how diabetes during pregnancy may affect a child's brain development over time.

This study aims to create and test a new questionnaire called LiCCoS for adults with liver cirrhosis. The goal is to help identify common thinking problems like forgetfulness and trouble focusing, which are often missed in regular checkups. About 230 participants will fill out th…

This study is developing a practical memory test for adults aged 70 and older. Researchers will compare test results between people with memory disorders (like Alzheimer's) and healthy seniors. The goal is to create a better tool for assessing everyday memory skills.

This study is testing whether a smartphone app can reliably measure thinking and memory changes in 200 adults with brain tumors. Participants will use the app to complete memory, attention, and problem-solving tests, and report their quality of life. The goal is to see if these d…