CHILDREN

This early study tests if blinatumomab can help children with severe lupus that hasn't responded to other treatments. Six participants will receive two short courses of the drug and be monitored for a year. The goal is to see if symptoms improve and to track any side effects.

This study tests a drug called romiplostim N01 in children and young adults (ages 6-24) whose platelet counts drop dangerously low after chemotherapy. The goal is to see if weekly injections can safely bring platelet levels back up within three weeks. About 50 participants will r…

This study tests whether a structured nutrition program can prevent malnutrition in children with solid tumors. About 400 children will receive personalized diet support from a team of experts. The goal is to improve weight, height, and overall health during treatment.

This study tests whether a single injection of Telpegfilgrastim works better than multiple daily injections of Filgrastim to prevent fever and dangerously low white blood cell counts caused by chemotherapy in children and teens (ages 6-24) with solid tumors. About 132 participant…

This study looks at the long-term safety of adding finerenone to standard blood pressure medicines for children aged 1 to 18 with chronic kidney disease and proteinuria (protein in urine). About 100 kids who were in an earlier study will take finerenone for up to 18 months. Resea…

This study looks at whether giving levothyroxine (a thyroid hormone medication) to children aged 4-15 with mild underactive thyroid (subclinical hypothyroidism) can improve how well their hearts pump blood. Researchers will measure heart function before and after treatment in 40 …

This study tests a combination of drugs (liposomal mitoxantrone, capecitabine, and anlotinib) in children, adolescents, and young adults whose solid tumors have returned or not responded to treatment. The goal is to see if this combo can shrink tumors and control the disease. Par…

This study tests two types of mouthwash—one with good bacteria (probiotics) and one with a special ingredient (ethyl lauroyl arginate)—to see which better reduces cavity-causing germs, plaque buildup, and acidity in the mouths of Egyptian schoolchildren aged 6 to 12. About 66 hea…

This study tests whether giving ozone gas through the rectum can help protect the brain in children who have suffered a brain injury from events like trauma, infection, or lack of oxygen. About 120 children from 1 month to 18 years old will receive the treatment while in intensiv…

This study tests whether giving tuberculosis (TB) preventive medicine right away to children and teens who live with a TB patient can prevent them from getting infected. About 647 participants aged 5 to 17 will either get immediate treatment or standard care. The goal is to see i…

This study tests whether a taurolidine lock solution, placed inside the catheter when not in use, can prevent infections better than a standard saline lock. About 148 children with cancer who need a central catheter will take part. The study is double-blind, meaning neither the p…

This study tests whether a high-flow nasal cannula (HFNC) can prevent dangerously low oxygen levels in children during the critical moment when anesthesia stops their breathing before a breathing tube is placed. The trial will enroll 48 healthy children aged 2-10 years undergoing…

This study tests a program designed to prevent childhood obesity in vulnerable families with children aged 6 months to 3 years. About 526 families with at least one parent who has overweight or obesity will take part. The program includes group sessions on healthy eating, physica…

This study tests whether cognitive-motor training (combining thinking and movement) or Pilates exercises better improve balance in children with Down syndrome. Thirty-two children aged 8 to 13 will do one of the two programs for 8 weeks. Researchers will measure balance and trunk…

This study tests two hands-on therapies—scooping mobilization and dynamic cupping—to see which better improves elbow motion and daily function in children aged 6–13 with stiffness after a broken arm. Each child receives one of the treatments plus electrotherapy for 4 weeks. The g…

This study looks at whether injecting botulinum toxin-A (like Botox) into the bladder can help children under 18 who have trouble urinating or wet the bed at night and haven't gotten better with standard treatments. The goal is to see if it improves symptoms and to track any side…

This study tests whether a nasal spray containing two medicines (dexmedetomidine and esketamine) can reduce pain in children after tonsil and adenoid surgery. About 160 children aged 3 to 7 will take part. The goal is to find a safe and effective way to manage pain without strong…

This study tests whether giving children oral melatonin or a nebulized medicine called dexmedetomidine before tonsil surgery can reduce confusion and agitation when they wake up. About 96 children aged 3 to 7 will take part. The goal is to find a better way to help kids recover c…

This study looks at whether adding biofeedback (a way to learn how to control muscles) to standard bladder training helps children with dysfunctional voiding (trouble peeing normally). About 124 children under 18 will take part. The goal is to see which approach works better for …

This study compares a long-acting opioid (methadone) to standard short-acting opioids for pain control in 60 children aged 6 months to 4 years undergoing cleft palate repair. The goal is to see if methadone reduces the total amount of opioids needed after surgery. The study is cu…

This study looks at whether high-dose omega-3 fatty acids can help reduce ADHD symptoms like inattention and impulsivity in children and teens who are low in omega-3. About 100 participants will take omega-3 supplements or a placebo for 12 weeks. The goal is to see if this natura…

This study looks at whether acupuncture can ease ADHD symptoms in children ages 6 to 12. Researchers will give some kids acupuncture plus herbal medicine, and others just herbs. They will track changes in attention, behavior, and quality of life over 12 months. The goal is to see…

This study looks at whether watching a short educational cartoon about the operating room can help lower anxiety in children aged 7 to 12 who are about to have surgery. About 159 kids will be split into three groups: one watches the educational cartoon, one watches a fun cartoon,…

This study tests a nasal spray combining two medicines (dexmedetomidine and esketamine) to help children aged 1-6 relax before surgery. The goal is to find the best dose that makes kids calm enough for a smooth start to anesthesia. 80 children will participate, and researchers wi…

This study follows 300 children conceived through assisted reproductive technologies (ART) like IVF and ICSI, from birth to age 3. Researchers will measure their physical growth, brain development, and reproductive health to see if these methods have any effects. The goal is to b…

This study looks at how physical activity affects thinking and learning in children born with heart problems. Researchers will compare these children to others having different surgeries or healthy siblings. They will also test if a 6- or 12-month exercise program can improve mem…

This study tests whether a personalized lung inflation technique can improve heart and lung function in two groups of children on breathing machines: those recovering from heart surgery and those with severe respiratory failure. Researchers will measure how well the lungs and hea…

This study tests two methods for teaching CPR to children in grades 1-6. One group gets a 2-hour hands-on session with a nurse and mannequin; the other watches a short video and does a puzzle. Researchers will measure which approach boosts CPR knowledge and skills better. About 5…

This study looks at whether game-like rewards, such as points, streaks, and levels, can encourage children to stick with healthy behaviors. About 160 children aged 9 to 12 will be split into four groups, each with a different reward system. The goal is to see which method best he…

This study uses safe brain imaging techniques (NIRS and EEG) to see how the brain controls movement in people with cerebral palsy and healthy volunteers. Researchers will compare brain activity patterns and test if biofeedback training can help improve movement coordination. The …

This study looks at how drinking milk or eating yogurt affects thinking and memory in healthy children aged 9 to 14. Researchers will test kids' attention, memory, and mood after they consume different dairy products. The goal is to understand how dairy might help the brain throu…

This study checks if a new device called the K-Pull dynamometer can reliably measure leg strength in healthy children aged 5 to 16. Researchers will compare it to a standard machine to see if it works well. The goal is to provide a simple, accurate way to assess leg function in k…

This study looks at the long-term health of children (16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's anti-rejection medications. Abou…