CHILDREN

This study tests the MVA-BN mpox vaccine in 344 infants and children aged 4 to 24 months in the Democratic Republic of the Congo, a high-risk area. Half receive a full dose and half a half dose, both given as two shots 28 days apart. The goal is to see if the vaccine is safe and …

This study follows children with congenital heart disease who have had the Fontan procedure and are prescribed rivaroxaban, a blood thinner, to prevent dangerous clots. Researchers will track bleeding events and other side effects using data from regular doctor visits. The goal i…

This study tests the safety and benefits of hydroxyurea, a daily medication, for children aged 3 to 10 with sickle cell anemia in Africa. The goal is to make this treatment more widely available to reduce pain and complications. Children take the drug long-term to control the dis…

This study tests a new way to manage blood flow in children after heart surgery. The approach focuses on keeping oxygen use and supply in balance during the critical first 8 hours after surgery. Researchers will enroll 300 children to see if this strategy reduces the risk of low …

This study aims to improve how we find and manage a common liver condition called MASLD in children aged 7 to 11 who are overweight. Researchers will test if measuring waist-to-height ratio is a good, low-cost way to screen for the disease. They will also create a lifestyle progr…

This study tests whether a combination of chemotherapy drugs (VP16 and carboplatin) followed by local heat therapy can control retinoblastoma, a rare eye cancer in children, without needing to remove the eye or use radiation. It involves 133 children with different stages of the …

This study looks at a program called 010 Fit'R for overweight children aged 4 to 12 in Rotterdam. The program helps kids and their parents make lasting changes to eating, physical activity, and motor skills. Researchers will measure things like quality of life, body mass index (B…

This study tests a program to help preschool children ages 3 to 6 in Suzhou, China, maintain a healthy weight. About 1,486 children will take part. The program includes healthy eating, physical activity, and education for families and teachers. Researchers will measure changes in…

This study tests a new way of caring for children under 10 with diabetes. The clinic uses play, calmness training, healthy lifestyle advice, and parent support groups to improve quality of life for both kids and their families. About 100 children and their parents will take part …

This study tests if using a palm stimulator or a stress ball can reduce pain, fear, and negative emotions in children aged 6-12 during a respiratory panel test (a nose or throat swab). 35 hospitalized children will be randomly assigned to use one of these tools or receive routine…

This study tests whether a next-generation exercise program, called Dynamic Neuromuscular Stabilization training, combined with ultrasound-guided pelvic floor exercises, works better than ultrasound-guided exercises alone for children aged 6-14 with dysfunctional voiding (trouble…

This study tests whether a low-cost, colorful walkway (like a mat carpet) can help children aged 4-10 feel less pain and fear when they first get up after abdominal surgery. About 74 children will use the walkway, and researchers will measure their pain, fear, and how quickly the…

This study looks at how secondhand smoke affects the gums of 146 healthy children. Researchers measure specific proteins and nicotine byproducts in saliva to detect early signs of gum inflammation. No treatment is given—the goal is simply to understand the link between passive sm…

This study planned to see if two monitoring tools—an ultrasound probe in the esophagus and a skin sensor that measures oxygen levels—could help doctors predict kidney injury early in children having heart surgery. The goal was to find a faster way to spot kidney problems during t…

This study looks at how virtual reality (VR) affects pain in the brain. Twenty healthy children aged 6 to 17 will wear a blood pressure cuff to create mild pain and a brain scanner while using VR games, a VR video, or an iPad game. The goal is to find brain signals that show when…

This study looks at whether a child's body position (sitting vs lying down) changes the results of a test that measures pressures in the bottom and rectum. Researchers will compare 120 children with and without constipation to find the best position for accurate diagnosis. The go…

This study looks at how different types of footwear—barefoot, minimalist shoes, and regular shoes—affect brain activity in 37 children aged 6-7 while they walk. Using a wireless EEG cap, researchers measure brain waves to see if shoe type changes how the brain controls movement. …

This study looks at why some parents of children aged 0 to 48 months are hesitant about vaccines. Researchers will use machine learning to find patterns in survey answers from 600 parents. The goal is to create a tool that can predict vaccine refusal, helping public health offici…

This study looked at whether adding special movement-and-thinking games to regular gym class helps preschool children think faster and balance better. Fifty typically developing kids took part; half did the extra activities twice a week for 8 weeks, while the other half only had …

This study examines autoimmune hyperthyroidism in children who develop the condition before age 6 and before puberty. Researchers will review medical records of 100 children to understand symptoms, lab results, and growth patterns at diagnosis and over time. The goal is to learn …

This study looks at whether a team-based plan can help doctors and staff better screen children for depression and connect them to mental health services. About 40 healthcare workers at a children's hospital will use a team charter to clarify roles and improve coordination. The g…