MECHANICAL VENTILATION

This study tests if levosimendan, a drug that strengthens the heart and breathing muscles, can help critically ill patients get off a ventilator faster. About 250 adults who have struggled to breathe on their own will receive either the drug or a placebo. The goal is to see if th…

This study tests whether using lung ultrasound to personalize breathing machine settings can reduce deaths in patients with acute respiratory distress syndrome (ARDS), a severe lung condition. About 538 adults on ventilators will be assigned to either standard care or ultrasound-…

This study involves 660 brain-injured patients on ventilators to see if a simple clinical score helps doctors decide the best time to remove the breathing tube. The goal is to reduce the need to put the tube back in or prevent death within 5 days. Participants are adults aged 18-…

This study tests whether placing warm sterile fluid into the womb during labor can reduce breathing problems in newborns when the amniotic fluid is stained with thick meconium. About 320 pregnant women at 36 weeks or later will be randomly assigned to receive either this fluid tr…

This study tests whether using lung ultrasound to guide removal of extra fluid can help ICU patients on breathing machines get off the ventilator sooner. About 1,000 adults who need a ventilator for at least another day will be randomly assigned to either ultrasound-guided fluid …

This study compares two common painkillers, fentanyl and hydromorphone, in patients who need a breathing machine in the ICU. The goal is to see if one leads to better outcomes, like using less pain medication overall and improving recovery. About 300 adults will take part, and th…

This study compares a new sedative called ciprofol to the standard drug propofol in 366 ICU patients who need a breathing tube. The goal is to see if ciprofol can sedate patients just as well but with fewer episodes of dangerously low blood pressure. Participants will be randomly…

This study tests whether adding non-opioid pain medicines like acetaminophen (Tylenol) and ketorolac (Toradol) can improve pain control and reduce the need for strong opioids in children on breathing machines. About 644 children aged 2 months to 17 years will be randomly assigned…

This study compares two methods (pressure support ventilation and T-piece) used to test if overweight ICU patients are ready to have their breathing tube removed. About 100 adults with a BMI of 25 or higher who have been on a ventilator for over 24 hours will be randomly assigned…

This study tests whether adding gentle electrical stimulation to the legs, alongside standard physical therapy, helps critically ill patients on breathing machines maintain or regain muscle strength. About 150 adults in the ICU will be randomly assigned to receive either physical…

This study tests whether a personalized lung inflation technique can improve heart and lung function in two groups of children on breathing machines: those recovering from heart surgery and those with severe respiratory failure. Researchers will measure how well the lungs and hea…

This study looks at how a specific part of the breathing cycle (the time it takes for the lungs to empty) affects how air and blood flow are matched in the lungs of patients with ARDS. Researchers will use a special imaging technique (EIT) to measure these changes in 60 adults on…

This study tests a new, less invasive way to measure diaphragm function using ultrasound during a breathing trial. About 60 adults on ventilators will be monitored for 30-120 minutes. The goal is to see if this method can detect early signs of diaphragm weakness, helping doctors …

This study looks at whether using extra monitoring tools during major abdominal surgery can help high-risk patients (aged 50 and older) spend less time on a breathing machine afterward. Half of the 100 participants will receive standard care, while the other half will have advanc…

This study looks at whether doing lung reopening maneuvers several times during spine surgery (while lying face-down) helps keep the lungs open better than doing it just once. Sixty adults having elective spine surgery will be randomly assigned to one of two groups. Doctors will …

This study watches 50 newborns who need a breathing machine to see if different machine settings cause different pain levels. Researchers place small sensors on the baby's foot to measure skin changes as a pain signal. They also test if holding the baby skin-to-skin helps reduce …

This study aims to create a prediction tool to identify which ICU patients who needed a breathing tube will benefit most from early rehabilitation. Researchers will collect data from 250 adults and use machine learning to build the algorithm. The goal is to reduce complications a…

This study observes how the breathing drive and effort of 40 adult ICU patients change when ventilator support levels are adjusted after major abdominal surgery. Researchers will use non-invasive measurements to identify patterns of under- or over-assistance. The goal is to help …

This study looks at whether ICU doctors and nurses make better predictions about a patient's chance of surviving one year when they are given a special risk score called ProVent-14. The score uses simple medical information collected after 14 days on a breathing machine. About 23…

This study looks at how short bursts of high oxygen affect blood flow in the brains of ICU patients on breathing machines. Researchers will safely increase oxygen levels for a brief time and use ultrasound to monitor brain artery responses. The goal is to learn how to better mana…

This study looks at whether using a short-acting paralytic drug (succinylcholine) instead of a longer-acting one (rocuronium) can prevent patients from being awake and aware while paralyzed during emergency breathing support. About 3,090 adults on ventilators in emergency departm…

This study watches how doctors decide when to remove breathing tubes (extubation) in extremely preterm babies (born before 28 weeks) during their first two weeks of life. Researchers will ask doctors daily why they choose to keep or remove the tube, and track whether the baby sta…

This study looks at how adjusting breathing machine settings based on individual lung scans can improve oxygen delivery in patients with moderate-to-severe acute respiratory distress syndrome (ARDS). Researchers will use a special imaging technique to measure how well air and blo…

This study tests whether a personalized program of nutrition and physical therapy, started early in the ICU and continued at home, helps people recover better after being on a breathing machine and heart-support medications. About 830 adults will be randomly assigned to either us…

This study aims to translate a pain scale called ESCID into Turkish and check if it works well for ICU patients on breathing machines who cannot talk. Pain is common in these patients but often missed. The goal is to give doctors a reliable tool to assess pain and improve care.

This study watches how hospitals around the world help patients get stronger after being on a breathing machine in the ICU. It will include about 2,400 adults and track what rehab they get, how it affects their recovery, and their quality of life after leaving the hospital. The g…

This study tests an artificial intelligence system called IntelliLung that gives recommendations on how to set a ventilator. Researchers will compare the ventilator settings chosen by healthcare staff with the AI's suggestions. The study includes 530 adults in the ICU who need a …

This study looks at patients who are ready to have their breathing tube removed after a breathing test. Researchers will collect information to see if they can predict when the tube might need to be put back in. The goal is to create a simple bedside tool to help doctors make bet…

This study compares two ways of using a breathing machine during weight-loss surgery in 40 adults with obesity. The goal is to see which method keeps oxygen levels higher and puts less pressure on the lungs. Results may help doctors choose safer breathing settings for future surg…

This study tests whether using a slower breathing rate on the ventilator is safe and practical for critically ill patients who need a breathing tube. About 84 adults in the ICU will be randomly assigned to either the standard approach or a gentler one that allows slightly higher …

This study observes 1500 adults with acute brain injury who need a breathing machine (ventilator) in the ICU. The goal is to understand how and when they can safely stop using the ventilator. Researchers hope this will help reduce complications and improve care for these patients…

This study looks at whether a special physiotherapy assessment (called EPIC) can help doctors know when it's safe to remove a breathing tube from patients in intensive care. About 330 adults who have been on a ventilator for more than 48 hours will take part. The goal is to reduc…

This early-stage trial tests whether a new method of giving muscle relaxants can help patients on breathing machines breathe on their own more safely. It involves 23 adults with severe breathing failure. The goal is to see if the approach is safe and feasible, not to cure or trea…

This study looks at how changing the pressure in a breathing machine (ventilator) affects the effort patients need to breathe on their own. It will include 12 adults in the ICU who are already using a ventilator to help them breathe. Researchers will test four different pressure …

This study looks at whether a brief increase in airway pressure after suctioning can reopen collapsed lung areas and improve lung volume in ICU patients on ventilators. About 32 adults will be randomly assigned to receive either suctioning alone or suctioning followed by a recrui…

This study watches 150 adult ICU patients on breathing machines to see how often they develop joint stiffness (contractures). Researchers measure joint movement and track factors like sedation and immobility. The goal is to find ways to prevent these problems and improve recovery…

This study looks at how a device called AbClo, which gently holds the belly together after surgery, affects breathing in patients whose abdomen is left open. Researchers will measure lung pressure and volume before and after adjusting the device, and again after the abdomen is cl…

This study observes 60 ICU patients on breathing machines to see if a special device can measure breathing effort and predict who will successfully breathe on their own. Participants will have their breathing muscles and oxygen use monitored during a standard breathing test. The …