Can warm fluid during labor prevent baby breathing problems?
NCT ID NCT07274527
First seen Jan 11, 2026 · Last updated Jun 22, 2026 · Updated 31 times
Summary
The PEARL trial is testing whether infusing warm sterile fluid into the uterus during labor can reduce breathing problems in newborns when the amniotic fluid is stained with thick meconium. About 320 pregnant women at 36 weeks or later will be randomly assigned to receive either the fluid infusion or standard care. The study also checks for inflammation and brain injury markers in cord blood and follows up with families when the child is 12 months old.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MECHANICAL VENTILATION are added.
Genom att skicka in godkänner du våra Användarvillkor
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Locations
-
Froedtert Hospital and Medical College of Wisconsin Birth Center
RECRUITINGMilwaukee, Wisconsin, 53045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
warm lactated ringer's solution infused into the uterus
What this could lead to
If it works, this could provide a simple, standardized way to reduce breathing problems in newborns exposed to thick meconium during labor.
What could go wrong
This is a relatively small trial (320 participants) and earlier studies on amnioinfusion had mixed results. The procedure may not significantly improve outcomes or could cause complications.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.