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Ultrasound-Guided ventilation aims to cut ARDS deaths

NCT ID NCT05492344

Disease control Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using lung ultrasound to personalize ventilator settings can reduce deaths in people with acute respiratory distress syndrome (ARDS). About 538 adults on breathing machines will be assigned to either standard care or a personalized plan based on their lung ultrasound pattern. The main goal is to see if this approach lowers the chance of dying within 90 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
personalized mechanical ventilation guided by lung ultrasound
What this could lead to
If successful, this approach could become a standard way to set ventilators for ARDS patients, potentially lowering the death rate from this serious lung condition.
What could go wrong
This is a large trial, but the intervention is complex and depends on staff training. The benefit may be small or not apply to all ARDS types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 538 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2022

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Admitted to a participating ICU, * invasively ventilated and * fulfil the Berlin criteria for moderate or severe ARDS. Exclusion Criteria: * Age under 18, * participation in other interventional studies with conflicting endpoints, * conditions in which LUS is not feasible or possible (e.g. subcutaneous emphysema, morbid obesity or wounds), * mechanical ventilation for longer than 7 consecutive days in the past 30 days, * history of ARDS in the previous month, * body-mass index higher than 40 kg/m², * intracranial hypertension, * broncho-pleural fistula, * chronic respiratory diseases requiring long-term oxygen therapy or respiratory support, * pulmonary fibrosis with a vital capacity \< 50% (severe or very severe), * previously randomized in the PEGASUS study * ECMO * patients who receive invasive ventilation in home setting due to a neurological disease * pregnant patients * patients who are moribund or facing end of life and * no informed consent.

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARDS, human Lung ultrasound Mechanical ventilation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    10 sites in 7 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Amsterdam UMC, location AMC

    RECRUITING

    Amsterdam, North Holland, 1105 AZ, Netherlands

  • Amsterdam UMC, location VUmc

    RECRUITING

    Amsterdam, North Holland, 1081HV, Netherlands

  • Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari

    RECRUITING

    Bari, Italy

  • Bispebjerg Hospital

    RECRUITING

    Copenhagen, Denmark

  • Centralny Szpital Kliniczny MSWiA

    RECRUITING

    Warsaw, Poland

  • Chu-Brugmann

    RECRUITING

    Brussels, Belgium

  • Evaggelismos Hospital

    RECRUITING

    Athens, Greece

  • Galway University Hospitals

    RECRUITING

    Galway, Ireland

  • Nordsjaellands Hospital

    RECRUITING

    Hillerød, Denmark

  • Ospedale Generale Regionale F. Miulli

    RECRUITING

    Acquaviva delle Fonti, Bari, Italy

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