MECHANICAL VENTILATION

This study tested two ways of using a breathing machine during emergency abdominal surgery. One method used higher pressure to open the lungs, while the other used lower pressure to avoid overstretching. The goal was to see which approach reduced breathing failure and death after…

This study tested a personalized approach to help patients in the intensive care unit (ICU) come off a breathing machine (ventilator). The strategy used daily checks and chose the best method to test breathing based on each patient's risk factors, like obesity or heart disease. T…

This study tested whether adding a painkiller called nefopam to standard care could reduce the amount of strong opioids needed for sedating critically ill patients on breathing machines. 60 adults participated in a double-blind trial. The goal was to see if nefopam could help pat…

This study tested if using mild electrical pulses on the breathing muscles (diaphragm and abdomen) helps patients who have been on a breathing machine for a long time to wean off it faster. 300 adults who needed a ventilator for at least 21 days were split into groups receiving r…

This study tested whether giving a combination of two sedative drugs (dexmedetomidine and esketamine) at night can improve sleep quality for adults in the intensive care unit who need a breathing machine or high-flow oxygen. Researchers measured sleep stages using brain monitorin…

This study looked at 236 adults in the surgical intensive care unit who needed a breathing machine for more than 4 days. Researchers wanted to see if the length of time a patient had anemia (low red blood cells) was related to how long they stayed on the ventilator. The goal was …

This study observed 66 ICU patients on breathing machines to see if ultrasound could detect differences in diaphragm thickness during different machine settings. Researchers compared measurements when the machine fully controlled breathing versus when patients breathed on their o…

This study looked at whether a low dose of ketamine, a drug often used for anesthesia, could help stimulate breathing in critically ill patients who are on a breathing machine (ventilator). Researchers measured airflow and brain activity in 15 adults in the ICU. The goal was to u…

This study tested a new way of using a breathing machine (ventilator) called VentCoach, designed to better protect the lungs of patients with severe breathing problems. 18 adults on ventilators for over 24 hours were included. The main goal was to see if doctors could follow the …

This study looked at 64 adults on breathing machines to see if changes in a chest muscle (parasternal intercostal) could help doctors decide the right time to remove the tube. Researchers measured muscle thickness before and during a breathing trial. The goal was to find a simple…

This study looked at 30 patients on breathing machines to see if the pressure in the tube's cuff could show how hard they were working to breathe. Normally, doctors use a thin tube in the esophagus to measure this, but that is more invasive. The results could lead to a simpler, s…

This study looked at how adjusting the speed at which a ventilator reaches its target pressure affects breathing in 17 newborns. Researchers tested different settings to see which ones improved oxygen and carbon dioxide exchange. The goal was to find the best ventilator settings …

This study looked at 77 ICU patients on breathing machines who needed a tracheostomy (a tube placed in the windpipe to help breathing). Doctors used either a tiny camera (bronchoscopy) or ultrasound to guide the procedure. The goal was to see how each method affected patients' br…

This study looked at 120 critically ill patients on breathing machines to see if a quick, non-invasive test called P0.1 could predict whether they would need the tube reinserted after removal. The test measures the effort to breathe in the first split second of an attempt. Resear…

This study looked back at the medical records of 50 children (ages 1 month to 18 years) who needed a breathing machine for more than 72 hours. Researchers wanted to see if adding inhaled sedatives could reduce the amount of other sedative and pain drugs needed. The goal is to fin…

This study looked at 101 adults having laparoscopic (keyhole) abdominal surgery to compare two levels of breathing support from a ventilator. The goal was to see if a higher, personalized pressure setting affects lung mechanics and oxygen levels differently than a standard low se…

This study looked at 60 adults with severe lung injury (ARDS) on breathing machines. It compared two ventilation methods—APRV and low tidal volume—to see which one better protects the right side of the heart from failing. The goal was to find out if one method is safer for the he…

This study looked at 28 critically ill patients on breathing machines to see if an ultrasound of the diaphragm could detect a specific breathing problem called double triggering asynchrony. Researchers compared ultrasound results to standard ventilator readings. The goal was to f…

This study looked at whether giving extra oxygen during heart-lung bypass affects kidney function after heart surgery. 104 adults having planned heart surgery took part. The goal was to see if extra oxygen helps or harms the kidneys and other organs.

This study looked at 80 obese adults having spinal surgery to see if adjusting the ventilator based on each person's lung stiffness works better than using a standard setting. The goal was to improve oxygen levels during surgery and reduce lung problems afterward. Researchers mea…

This study looked at whether giving sedation through inhalation (breathing it in) instead of through an IV can reduce the work of breathing in patients on ventilators. 40 ICU patients were randomly assigned to receive either inhaled sedation or standard IV sedation. The goal was …

This study followed 156 adults who needed a tracheostomy (a tube in the throat) to help them breathe and eventually stop using a breathing machine. Researchers measured how long recovery took, how often patients felt short of breath or uncomfortable, and how this affected their q…

This study observed 91 ICU patients on breathing machines who needed a tracheostomy (a tube in the windpipe). Researchers compared those who continued tube feeding until the procedure with those who fasted for 6-8 hours. The goal was to see if feeding increased the risk of aspira…

This study looked at how breathing machines (ventilators) are used in intensive care for patients with serious brain injuries, like from trauma or stroke. Researchers collected data from over 2,200 patients across many hospitals to see which ventilator settings are common and how…

This study tested a new way of removing a breathing tube after digestive surgery to see if it prevents low oxygen levels. About 208 adults having surgery lasting over an hour were randomly assigned to either the standard method or a method that keeps positive pressure on the lung…

This study looked at whether a simple test using a ventilator (PEEP test) can predict if a patient in shock needs more fluids. 66 adults on breathing machines were monitored to see if the test could avoid giving extra fluids when not needed. The goal was to find an easier way to …

This study tested a personalized online decision-support tool called TRACH-Support for families and medical teams facing decisions about long-term breathing support, such as a tracheostomy. The tool was reviewed by 105 family members and healthcare providers, who then completed s…

This study tested whether using physical restraints (like wrist straps) less often in ICU patients on breathing machines could reduce the time they spend in delirium (confusion). 423 adults from 6 hospitals were randomly assigned to either routine restraint use or restraint only …

This study looked at 78 adults who had heart surgery and needed a breathing tube afterward. Researchers compared using a manual bag versus a mechanical ventilator while moving patients from the operating room to the ICU. The goal was to see which method keeps blood pressure and o…

This small study tested whether electrically pacing the diaphragm could improve lung function in brain-dead organ donors whose lungs were initially not good enough for transplant. Three donors received a temporary pacing catheter. The goal was to see if the approach is safe and f…

This study looked at 40 ICU patients to see if eye pressure changes when they stop using a breathing machine and start breathing on their own. Researchers measured eye pressure before and after the switch using a simple, non-invasive device. The goal was to learn more about eye h…

This study tested whether an automatic device (IntelliCuff) is better than manual checks for keeping the cuff pressure of breathing tubes in the right range for children in intensive care. 32 children on ventilators were monitored for 24 hours with each method. The goal was to se…

This study looked at how changing the ventilator's air volume and pressure during surgery affects pressure inside the lungs and chest. Researchers used a small balloon placed in the esophagus to measure these pressures in 150 adults having elective surgery. The goal was to better…

This study looked at 110 adults on breathing machines to see if a special deep breath (a sigh) can help doctors measure lung stiffness and find out if the lungs can be opened up more. The goal was to see if using sigh information to adjust machine settings improves breathing comp…

This study tested a new way of helping patients breathe after a lung injury. It compared different levels of a special ventilator mode called NAVA to see how it affected breathing and comfort. Fifteen adults in intensive care took part. The goal was to learn how the body responds…