MECHANICAL VENTILATION

This study looks at whether esketamine, a drug related to ketamine, can safely sedate and prevent delirium in 80 adults with sepsis who need a breathing machine. Sepsis is a severe infection that can cause organ failure, and current sedatives have side effects like breathing prob…

This study looks at how the amount of air left in the lungs after breathing out affects diaphragm strength. Researchers will test 30 healthy people and ICU patients on ventilators to see if adjusting for lung volume gives more accurate strength measurements. The goal is to help d…

This study observes how doctors, patients, and families use time-limited trials (TLTs) for people in the ICU who need a breathing machine. A TLT is a shared plan to try ICU treatments for a set time, then check if the patient is recovering. The goal is to find the best way to use…

This study looks at whether the type of breathing machine setting used in the ICU affects how well patients recover. Researchers will switch the ventilator mode used in entire ICUs every two months and track survival and time off the machine. About 4,785 adults on breathing machi…

This study looks at how much older adults move while in the intensive care unit (ICU) for a critical illness like sepsis or respiratory failure. Researchers want to see if more activity during the hospital stay leads to fewer disabilities and better physical and mental function 3…

This quality improvement study tests a software system that gives ICU teams real-time feedback on ventilator settings and patient data. The goal is to reduce ventilator-associated events and lung injury in 875 patients on breathing machines. Researchers will compare outcomes befo…

This study looks at how much energy critically ill patients on breathing machines use during routine bed exercises. By measuring oxygen consumption with a special device in the ventilator, researchers hope to understand the physical demands of these exercises. The goal is to make…

This study looks at whether repeated measurements of certain biomarkers in the blood can help predict if a patient in the ICU will need to be put back on a breathing tube after it is removed. The study involves 266 adults who have been on a ventilator for more than 48 hours and a…