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New biomarker strategy aims to prevent failed breathing tube removals in ICU

NCT ID NCT05637099

Knowledge-focused Sponsor: Henrik Endeman Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether repeated measurements of certain biomarkers during a spontaneous breathing trial can help predict which ICU patients will need to be re-intubated within 7 days. Researchers will follow 266 adults who have been on a ventilator for more than 48 hours and are ready to try breathing on their own. The goal is to improve decision-making and reduce complications from failed extubation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

181 people

The number who actually took part.

Started

Aug 2022

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients admitted to the ICUs of the Erasmus MC, the Franciscus Gasthuis \& Vlietland, Groene Hart ziekenhuis, Amphia ziekenhuis, and OLVG, who are mechanically ventilated for more than 48 hours.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged ≥18 years * Mechanically ventilated for more than 48 hours * Fulfilling readiness-to wean criteria * Written informed consent from the patient or his/her legal representative Exclusion Criteria: * Patients with risk factors for laryngeal oedema and a negative cuff leak test (indicating upper airway obstruction with need for steroid treatment) * Planned replacement of the endotracheal tube for a tracheostomy * Terminal illness

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Extubation failure Mechanical ventilation Spontaneous breathing trial Weaning failure

Contacts and locations

Locations

  • Erasmus MC

    Rotterdam, South Holland, 3015 GD, Netherlands

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