Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a Ketamine-Like drug improve sedation for sepsis patients on life support?

NCT ID NCT07556172

Disease control Sponsor: Second Affiliated Hospital of Nanchang University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests esketamine, a drug related to ketamine, for sedation and delirium prevention in 80 septic patients who need a breathing tube. The goal is to see if esketamine can reduce time on the ventilator and improve survival compared to standard sedatives. The trial is active but no longer recruiting participants.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Esketamine
What this could lead to
If successful, esketamine could offer a safer sedation option for septic patients on ventilators, potentially reducing delirium and improving outcomes.
What could go wrong
This is a small, single-center phase 4 trial with only 80 participants. Esketamine's benefits for this specific use are unproven, and side effects like hallucinations or blood pressure changes are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Meet Sepsis-3.0 diagnostic criteria. * Age ≥ 18 years. * Required invasive mechanical ventilation. * Expected ICU stay ≥ 24 h. Exclusion Criteria: * Pregnant or lactating women. * Pregnant or lactating women. * Child-Pugh class C or worse. * Severe renal impairment (Scr \> 178 µmol/L or BUN \> 9 mmol/L). * Pre-existing delirium, dementia, or other psychiatric disorder. * Known allergy to opioids or benzodiazepines. * Uncontrolled hypertension (SBP \> 180 mmHg or DBP \> 100 mmHg). * Preeclampsia/eclampsia. * Significant ischemic heart disease. * Severe pulmonary dysfunction.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Mechanical ventilation are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

infectious disease with sepsis Sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical ventilation Sepsis

Contacts and locations

Locations

  • The Second Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330000, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.