Could a Ketamine-Like drug help sepsis patients on ventilators?

This study looks at whether esketamine, a drug related to ketamine, can safely sedate and prevent delirium in 80 adults with sepsis who need a breathing machine. Sepsis is a severe infection that can cause organ failure, and current sedatives have side effects like breathing problems or confusion. Esketamine may offer better sedation with fewer risks, and researchers will measure how long patients need the ventilator and their survival at 28 days.