SEPSIS

This study tests whether adding two steroids (hydrocortisone and fludrocortisone) to standard care can reduce death or long-term organ failure in adults with sepsis. About 1,800 ICU patients will be randomly assigned to receive the steroid combination or a placebo. The main goal …

This study tests an experimental drug called AZD4144 in adults with sepsis who develop acute kidney injury. About 124 participants will receive either the drug or a placebo daily while in the hospital. The main goal is to see if the drug helps improve kidney function compared to …

This study tests a new blood-filtering method (DPCAS+LPE) for people with sudden liver failure and sepsis. About 192 adults will receive either this new treatment or standard plasma exchange. The goal is to see if the new method lowers death rates at 4 and 12 weeks and reduces in…

This study tests whether using a combination of gentamicin and a narrow-spectrum antibiotic is as safe and effective as using a broad-spectrum antibiotic alone for people with early sepsis. About 1,900 adults hospitalized with suspected sepsis will be randomly assigned to one of …

This study tests an experimental drug called YD0743 in adults with sepsis who have developed severe lung failure (ARDS) and need a breathing machine. The main goal is to see if the drug can shorten the time patients need a ventilator. About 309 ICU patients will receive either YD…

This study looks at whether a special filter called oXiris helps people with septic shock and acute kidney injury who need blood filtering. The filter aims to remove harmful toxins and calm inflammation. Researchers will compare survival and recovery in 360 adults who received ei…

This study looks at whether a balanced gelatin solution is better than standard fluids for people with sepsis (a severe infection) who need emergency abdominal surgery. Sepsis causes fluid loss, which can lead to low blood pressure and organ damage. The trial will compare the two…

This study tests two ways to treat sepsis early in the emergency department. The standard method starts with IV fluids, then adds a blood-pressure-raising drug (norepinephrine) if needed. The experimental method gives the drug first, then adds fluids if needed. About 1,000 adults…

This study tests whether patients with serious infections who are at risk of developing sepsis can be safely monitored at home using wearable devices and a smartphone app. About 120 adults will take part, and the goal is to catch early signs of worsening health so they can get he…

This study tests a new medicine, BAY 3389934, in people with sepsis who develop a dangerous blood clotting problem. The goal is to find a safe dose and see how the drug affects the body. About 36 adults in the ICU will take part, and the study lasts around 28 days.

This early study tests whether draining lymph fluid from a chest tube can lower harmful inflammation in people with septic shock. Ten adults in the surgical ICU will receive the drainage for up to 7 days. The goal is to see if the procedure is safe and can reduce inflammatory pro…

This study looks at 600 ICU patients with sepsis caused by drug-resistant bacteria. It compares giving antibiotics continuously versus intermittently, and also tests if using two antibiotics together works better than one. The main goal is to see which approach lowers the chance …

This study tests whether having nurses measure blood flow in tiny vessels (microcirculation) can help doctors start fluid treatment earlier for sepsis patients in the emergency room. About 556 adults with suspected sepsis will be enrolled. The goal is to see if this approach redu…

This early-stage study tests whether a drug called DNase I is safe and feasible for ICU patients with sepsis. Sepsis is a life-threatening response to infection that can cause organ failure. The trial will enroll 36 adults and monitor how many complete the treatment and how their…

This study tests whether giving a blood-pressure-raising drug (norepinephrine) early and adjusting the dose quickly can help adults with septic shock survive longer. Researchers will compare this approach to standard care in 600 patients. The goal is to see if early treatment red…

This study tests whether a nerve block in the back (erector spinae plane block) can improve organ function in septic patients who also have acute gut injury. About 116 adults in intensive care will receive the block plus standard care or standard care alone. The goal is to see if…

This study tests a drug called ivabradine in people with sepsis, a life-threatening infection that often causes a dangerously fast heart rate. The goal is to see if ivabradine can safely lower heart rate and improve blood flow without weakening the heart. About 172 adults in inte…

This study tests whether giving fluids and blood-pressure medicine based on each person's heart response can improve care for sepsis patients in the emergency department. Sepsis is a life-threatening reaction to infection that can cause organ failure. The study will compare a per…

This study tests whether a drug called fisetin can reduce organ failure in older adults (65+) with mild sepsis. Sepsis is a severe response to infection that can damage organs. The drug targets aging cells that may make the body's response worse. The trial will compare two doses …

This study looks at 300 adults with septic shock in the ICU. It uses a computer tool to randomly assign patients to get vasopressin either early or later, based on their norepinephrine dose. The goal is to see if the timing affects how much norepinephrine they need and if the too…

This study follows 200 adults with sepsis or septic shock who are receiving ARTICE® therapy in the ICU. Researchers will track changes in organ function, lab results, and recovery times to better understand how well the treatment works and who benefits most. The goal is to improv…

This study tests whether a program that includes guidelines, feedback, and education can help doctors use less vancomycin (a strong antibiotic) in children with suspected sepsis in intensive care units. The goal is to reduce side effects like kidney damage while still treating in…

This study tests whether a personalized treatment with Pentaglobin (a mix of antibodies) can improve recovery in people with severe abdominal infection (peritonitis) that has led to sepsis or septic shock. About 200 adults will receive either standard care or standard care plus P…

This study looks at two ways to clean the blood in children with sepsis, a life-threatening infection. It compares continuous blood purification (done without stopping) to non-continuous methods. The goal is to see which approach helps more children survive 28 days after leaving …

This study tests whether checking vancomycin levels after the very first dose and adjusting quickly can help infants with sepsis reach the right drug levels faster. About 40 infants under 90 days old will take part. The goal is to avoid dangerous delays in treating serious infect…

This study tests whether early use of midodrine, a pill that raises blood pressure, can help people with sepsis need less IV medicine and recover faster. About 308 adults with sepsis and low blood pressure will receive midodrine or a placebo. The goal is to see if it reduces time…

This study tests two types of blood purification filters (AN69ST and polysulphone) in 80 children with sepsis. The goal is to see which filter better reduces harmful inflammatory substances and organ damage. Children aged 29 days to 18 years with sepsis-related organ failure may …

This study looks at whether a computer tool called pediatric eCART can help doctors quickly identify hospitalized children at high risk for serious problems like cardiac arrest or sepsis. Researchers will compare data from before and after the tool was put into use, involving up …

This study is looking at a specific blood marker called glycosylated ferritin to see if it can help doctors better distinguish between three serious conditions: Still's disease, sepsis, and macrophage activation syndrome. These illnesses can look very similar, making diagnosis di…

This study tests whether using a device that measures blood flow to the skin (called the peripheral perfusion index) can help doctors give fluids more precisely to elderly ICU patients with sepsis or shock. The goal is to prevent acute skin failure, a serious condition where the …

This study tests a device that sends mild electrical pulses to the thigh muscles of people in the ICU. The goal is to see if it is safe and practical to use, and whether it can slow down muscle weakening. About 50 critically ill patients will either receive standard care or stand…

This study explores whether virtual reality (VR) can help patients in the intensive care unit (ICU) feel more relaxed, improve their mood, and keep their minds active. About 32 adults with acute respiratory failure or sepsis will use VR for 15–45 minutes each day for up to 5 days…

This study looks at whether a computer program can analyze data already collected in hospitals to help diagnose sepsis and septic shock more quickly. Researchers will study the records of 10,000 ICU patients to see if the program can speed up diagnosis and improve outcomes. The g…

This study looks at why sepsis causes long-term immune system problems, making people more likely to get serious infections again. Researchers will study blood samples from 150 ICU patients with sepsis over 28 days. The goal is to find the root causes of immune dysfunction, not t…

This study aims to understand how inflammation from infections or major surgery can harm the kidneys. Researchers will measure certain proteins in urine, blood, and sputum from 100 ICU patients with sepsis, after surgery, or after poisoning. The goal is to find early markers that…

This study tests a new ultrasound technology called NeoDoppler that can continuously monitor blood flow in the brains of sick and premature infants. Researchers will enroll 180 newborns, including healthy preterm and term babies as well as those with conditions like heart defects…

This study looks at why many people who survive a serious illness in the ICU develop lasting muscle weakness. Researchers will test the heart and blood flow of 50 former ICU patients during exercise. The goal is to better understand the problem, not to test a new treatment.

This study follows 40 people who survived sepsis in the ICU to understand how their physical function changes after leaving the hospital. Researchers will measure strength and mobility with simple tests and look at how hospital readmissions affect recovery. The goal is to learn m…

This study looks at whether measuring the water outside cells (extracellular water) can help doctors better understand fluid status in adults with sepsis who are in intensive care. Researchers will measure this water in 20 patients receiving standard care. The goal is to see if t…

This study is watching 1,000 ICU patients to find early signs in their bodies that could help doctors diagnose life-threatening conditions like sepsis and ARDS sooner. The goal is to learn which patients might benefit from specific treatments and to discover new therapies. No exp…

This study is an anonymous online survey that measures how much healthcare workers in seven sub-Saharan African countries know about sepsis. About 300 doctors, nurses, and trainees will answer questions to identify knowledge gaps. The survey is repeated every 12-24 months to trac…

This study looks at how severe infections (sepsis) and major injuries change the way the body produces certain immune cells. Researchers will measure specific white blood cells in 450 adults to understand why some people develop long-term immune problems. The goal is to learn mor…

This study looks at how the immune system reacts during and after sepsis in 400 intensive care patients. Researchers will analyze blood samples to identify different immune response patterns, called immunotypes. The goal is to understand which patterns lead to better or worse out…

This study looks at whether a new guideline can safely reduce the number of tests, antibiotics, and hospital stays for babies 60 days old or younger who have a fever. About 2,500 babies will take part across 11 hospitals in Sweden. The goal is to see if the new approach works as …

This study looks at how the antibiotic ceftazidime avibactam behaves in children with severe infections who are in intensive care and on life support. Researchers will measure drug levels in the blood to better understand dosing. The goal is to improve treatment for sepsis and se…

This study looks at how a type of white blood cell called neutrophils changes in children with sepsis, a severe infection. Researchers will compare blood and breathing tube samples from 75 patients in the ICU with sepsis to those from children having planned surgeries. The goal i…

This study looks at how well a drug combination called sulbactam-durlobactam works against hard-to-treat infections caused by a superbug called CRAB. About 200 hospitalized adults will be observed, and their outcomes will be compared to those receiving other treatments. The goal …

This study aims to see if a new scoring tool called SOFA-2 can better predict which ICU patients are at risk of dying within 30 days compared to the current standard. Researchers will also measure how common sepsis is in Turkish intensive care units. About 2,500 adult ICU patient…

This study will see if a special device called PIVO can help collect blood cultures in the emergency department with fewer needle sticks. Researchers will train staff to use the device and then track how often it is used and whether it leads to fewer contaminated samples. The goa…

This study looks back at medical records of 1,500 ICU patients with sepsis and low platelet counts to see if platelet transfusions help them survive 28 days. It also checks for bleeding and blood clots. The goal is to learn whether this common treatment actually helps or harms, s…

This study looks at neutrophils, a type of white blood cell, in children with sepsis, a severe infection that can damage organs. Researchers want to understand how these cells change and cause harm, so they can develop treatments to protect the body. The study involves 72 childre…

This study involves 150,000 adult hospital patients and tests two new risk scores: one that predicts sepsis risk within four hours, and another that predicts sudden deterioration (like cardiac arrest or unplanned ICU transfer). The goal is to see if giving doctors these scores he…

This study is observing 183 adults in the ICU with sepsis or septic shock to see if their cortisol levels can predict who is at higher risk of dying. Researchers will measure cortisol and track deaths in the ICU, at 28 days, and at 90 days. No treatments are given—the goal is to …

This study looks at whether measuring how much a vein near the armpit collapses can predict if a sepsis patient needs more fluids. It involves 40 adults with sepsis who are breathing on their own and have signs of poor blood flow. Doctors will use ultrasound to check the vein bef…

This study follows 300 critically ill children who had sepsis for five years after they leave the hospital. Researchers want to see how sepsis affects their growth, brain development, survival, and quality of life. The goal is to better understand the long-term challenges these c…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis or infection in the ICU. The new method adjusts the dose based on the patient's kidney function using doses already available in hospitals. The main goal is to see if doctors and nurs…

This study aims to better understand how enteroviruses, especially Echovirus 11, affect newborns in Italy. Researchers will analyze samples from 1,600 infants admitted to neonatal intensive care units to track the virus's spread, identify risk factors for severe illness, and impr…

This study aims to find biological markers that can predict whether a patient with sepsis will develop a more severe form called septic shock. Researchers will compare epigenetic markers in the blood of 25 male patients aged 45-75 who have sepsis after major digestive cancer surg…

This study looks at whether a blood test marker called Monocyte Distribution Width (MDW) can help predict serious complications and survival in older adults with hip fractures. About 100 patients aged 65 and older will be followed after surgery to track infections, hospital stays…

This study looks at how the OXIRIS membrane, a special filter used in kidney replacement therapy, affects blood clotting and immune cells in ICU patients with septic shock. Researchers will measure markers of platelet activation and immune response before and after treatment. The…

This study is looking at whether early signs in the blood can help doctors identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults to see how well these early markers predict death and organ failure within 28…

This observational study looks at whether certain genetic elements, called transposable elements, can prematurely age the immune system of people with sepsis in the ICU. Researchers will collect blood samples from 116 adult patients to see if these elements are linked to higher d…

This study looks at a rare but dangerous infection caused by Bacillus cereus bacteria in premature newborns. Researchers will analyze the bacteria's DNA and review medical records from 40 babies to identify which genetic features are linked to higher death risk. The goal is to be…

This study aims to create a new scoring system to better predict which pregnant or recently postpartum women in the intensive care unit (ICU) are at risk of dying. Researchers will collect routine medical data from 130 participants to see if a pregnancy-adjusted score works bette…

This study uses a blood test to measure organ damage and immune system changes in 1,000 people with sepsis. Researchers want to see if this test can predict survival and how long patients stay in the ICU. The study does not provide a new treatment, but aims to better understand t…

This study is collecting blood and other samples from 2,000 adults who come to the emergency room with a suspected respiratory infection. The goal is to build a biobank to better understand how different infections affect the body. Researchers hope this will lead to new ways to d…

This study tests whether using changes in procalcitonin levels over time (kinetics) is better than using a single procalcitonin value to decide when to start antibiotics in critically ill patients with suspected infection. About 250 adults in the ICU will be randomly assigned to …

This study looks at how long the Oxiris hemofilter can effectively remove harmful toxins from the blood in adults with septic shock in the ICU. Researchers will take blood samples before and after the filter to measure its cleaning power over 24 hours. The goal is to find the bes…

This study observes about 1,950 emergency patients with suspected sepsis to see how well certain blood markers (like calprotectin) and rapid DNA tests can detect infections. The goal is to improve diagnosis and tailor treatment to each patient. Participants are adults admitted to…

This study checks if a new, over-the-counter continuous glucose monitor (Syai Tag) is accurate and safe for ICU patients. About 100 adults in intensive care who need blood sugar checks will wear two small sensors on their arms. Researchers will compare the sensor readings with st…

This study looks at whether personalized dosing of the antibiotic vancomycin can reduce kidney injury in children with sepsis. Researchers will use new models that account for each child's kidney function to find the right dose. The trial involves 20 children in intensive care. T…

This study is observing 4,000 adults in intensive care with ARDS, sepsis, or pneumonia to identify different types of these illnesses. Researchers will collect medical information and samples to build a biobank for future studies. The goal is to improve understanding of risk fact…

This study is developing artificial intelligence (AI) tools that can help doctors make better, personalized decisions for patients with heart disease, breast cancer, or sepsis. The goal is to make AI recommendations clear and trustworthy for doctors, while also ensuring safety. T…

This study is a large registry that collects data on how a blood-filtering device called CytoSorb is used in real-world intensive care settings. It will include up to 3,000 critically ill patients with conditions like septic shock, severe lung injury, or liver failure. The goal i…

This study is looking for new ways to quickly diagnose sepsis, a life-threatening reaction to infection, in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve early …

This observational study looks at how severe trauma changes the body's blood and bone marrow, aiming to understand why some patients become immune-suppressed and develop infections like sepsis. Researchers will collect blood and bone marrow samples from 255 trauma patients and co…