SEPSIS

This pilot study tests whether adding fludrocortisone to usual hydrocortisone treatment helps control septic shock in 32 critically ill adults. Septic shock is a life-threatening condition where the body's response to infection causes dangerously low blood pressure. The main goal…

This early-stage study tests a new drug called OPT101 in 26 adults hospitalized with community-acquired pneumonia and sepsis. The main goal is to check the drug's safety and how the body processes it. Participants will receive either OPT101 or a placebo for up to 4 days. This res…

This study compares different blood purification techniques in 120 children with sepsis (a severe infection causing organ damage). The goal is to see which method best removes harmful inflammatory substances from the blood. Researchers will measure changes in inflammation and org…

This study tests whether adding an experimental drug (NAI) to standard care can help critically ill sepsis patients with persistently low lymphocyte counts (a sign of immune weakness) survive longer. About 50 adults in the ICU will be randomly assigned to receive either NAI injec…

This early-stage study tests a drug called romiplostim N01 in 280 adults with sepsis and very low platelet counts. The goal is to see if it can safely raise platelet levels better than the current treatment. Researchers will also track survival, side effects, and hospital stay le…

This study tests whether the steroid methylprednisolone can improve organ function and reduce deaths in critically ill patients with sepsis or acute respiratory distress syndrome (ARDS) who have a hyperinflammatory condition. About 150 adults will receive either a high or low dos…

This study tests a newer blood thinner, nafamostat mesylate, against the standard citrate for patients with sepsis and severe kidney injury who need continuous dialysis. The goal is to see if the newer drug works just as well or better at preventing death, ongoing kidney failure,…

This study tests whether curcumin, a natural compound in turmeric, can help control the dangerous immune overreaction in sepsis. About 56 critically ill adults will receive either curcumin or a placebo alongside standard care. The goal is to see if curcumin reduces inflammatory m…

This study tests whether N-acetylcysteine, an antioxidant, can help adults with severe infections or sepsis who also have liver problems. The goal is to see if it increases the number of days patients are alive and out of the hospital within two weeks. 360 participants will recei…

This early-stage study tests whether adding the iron-binding drug MEX-CD1 to dialysis fluid can safely remove extra iron in adults with sepsis-related acute kidney injury in the ICU. Fourteen participants will each receive two 24-hour dialysis sessions—one standard and one with t…

This study tests whether a standard set of emergency steps—like quick blood tests, fluids, and antibiotics—can improve survival for adults with sepsis or septic shock. Researchers will compare results from 74 patients treated before the new protocol to 46 patients treated after i…

Sepsis harms the protective lining of blood vessels, leading to organ failure. This study tests whether giving fresh frozen plasma—either as short bursts or a steady drip—can repair that lining better than a placebo. About 45 adults with sepsis in the ICU will receive the treatme…

This study looks at two methods of giving a common type of antibiotic (beta-lactam) to adults with sepsis or septic shock in the ICU. One method gives the drug continuously over time, while the other gives it in short bursts. The goal is to see which approach helps more patients …

This study tests whether Ringer's lactate or normal saline is better for the first fluids given to adults with sepsis in the emergency department. About 88 participants will receive one of the two fluids and be monitored for 24 hours to see who survives and needs less support. Th…

This study tests whether adding a steroid (hydrocortisone) and a powerful antibiotic combination to standard care can help more people with HIV survive sepsis, a life-threatening infection reaction. About 344 adults in Africa will take part. The goal is to find a better treatment…

This early-stage trial tests whether the drug Racecadotril can help protect organ function in people with sepsis, a life-threatening response to infection. About 44 adults in intensive care will receive either the drug or a placebo, in addition to standard sepsis treatment. The m…

This study compares two drugs—fenofibrate (a cholesterol medicine) and silymarin (a milk thistle extract)—in 66 adults with sepsis, a life-threatening infection that can cause organ failure. The goal is to see which drug better reduces inflammation and organ damage. Participants …

This study compares two common antibiotic combinations to see which one is less likely to harm the kidneys of hospitalized adults with serious infections. About 852 participants will be randomly assigned to receive either vancomycin plus piperacillin/tazobactam or vancomycin plus…

This study tests two ways to follow up with adults who survived sepsis in the hospital. About 1,410 patients in four African countries will get either an enhanced discharge plan or that plus automated phone check-ins. The goal is to see if these strategies reduce deaths within 90…

This study looks at whether giving antibiotics over 3 hours works better than the usual 30-minute drip for critically ill children (0-17 years) with severe infections like sepsis. About 110 kids in intensive care will get the same dose of antibiotic, just at different speeds. Res…

This study tests whether a daily capsule of pasteurized Akkermansia muciniphila (a food supplement) can safely help adults recover after being in the ICU for sepsis. Fifty participants will take either the supplement or a placebo for 56 days. Researchers will check for side effec…

This study tests whether tailoring sepsis treatments to each patient's specific biological traits can improve survival and reduce time on life support. About 2000 children and adults with sepsis will receive either standard care or treatments guided by their individual biomarkers…

This study tests a new pre-mixed fluid that contains phosphate for ICU patients needing continuous kidney dialysis (CRRT). Standard fluids can wash out phosphate, causing muscle weakness and breathing problems. The trial will compare the new fluid to the standard one in 220 adult…

This study tests whether giving a calming drug called dexmedetomidine early can help people with septic shock. The drug aims to calm an overactive nervous system, reduce organ damage, and improve survival. About 168 adults will receive either the drug or a placebo for 48 hours, a…

This study looks at a new rapid test called NuRapid-CRISPR that quickly finds the germs causing sepsis in ICU patients. It compares the test's accuracy to standard lab cultures and checks if using the test's fast results to guide treatment can lower the chance of death within 28 …

This study aims to create a screening tool that uses artificial intelligence and special blood tests to help doctors spot sepsis in children sooner. Sepsis is a life-threatening reaction to infection, and early treatment saves lives. The tool will be tested in emergency rooms usi…

This study will test a new tool called the Sepsis ImmunoScore to see if it helps doctors diagnose sepsis more quickly and accurately. Sepsis is a life-threatening reaction to infection. The study will include 5000 adults in U.S. hospitals who are suspected of having sepsis. Resea…

This study looks at whether a simple calculation using heart rate and blood pressure (called the Modified Shock Index) can help predict how serious sepsis will be for patients in the emergency room. Researchers will follow 70 adults with sepsis to see if this measure relates to o…

This study looks at how sepsis changes the RNA in immune cells over time. Researchers will follow 200 sepsis patients, 50 other critically ill patients, and 40 healthy controls to map these changes. No treatments are tested; the goal is to better understand why immune problems pe…

This study will look at 40 newborns in intensive care to understand why some develop anemia (low red blood cells). Researchers will track risk factors like mother's health and birth details, and see how anemia affects hospital stay, need for transfusion, and overall health. The g…

This study looks at how immune cells change in adults with severe infections like sepsis who are in the ICU. Researchers want to see if certain immune patterns can predict survival, organ failure, or length of ICU stay. About 200 participants will provide blood samples and allow …

This study is a registry that will follow 760 adults hospitalized with sepsis to learn how they are treated in the hospital and how they recover after discharge. Researchers will track deaths and major health events like heart attacks or strokes for up to a year. The goal is to b…

This study tests whether giving a simple educational brochure to sepsis survivors before they leave the ICU is practical and helpful. Researchers will enroll 30 adults with sepsis to see if they can successfully deliver the brochure and follow up with surveys. The goal is to lear…

This study looks at whether the type of anesthesia given during surgery affects lung injury in patients with sepsis. About 480 adults with sepsis who need surgery will be randomly assigned to receive either inhaled or intravenous anesthesia. Researchers will track how many days t…

This study aims to create a predictive model that helps doctors quickly identify which sepsis patients in the emergency department are likely to have drug-resistant infections. By analyzing data from 10,000 adults, researchers hope to improve antibiotic selection, reduce the spre…

This study compares three computer programs designed to predict sepsis, a life-threatening response to infection. Researchers will test these programs on 1,200 adults arriving at the emergency department, but the predictions will not be shared with doctors or patients. The goal i…

This study looks at 130 adults with sepsis to see if a kidney ultrasound (renal resistance index) and a urine test can predict acute kidney injury before it happens. Researchers will measure these markers right after sepsis diagnosis and track who develops kidney problems. The go…

This study looks at how a common antibiotic combination (piperacillin-tazobactam) is removed from the blood by continuous kidney replacement therapy in intensive care patients with severe infections. The goal is to find the right dose to avoid underdosing (which can lead to treat…

This study looks at whether a special blood test measuring neutrophil fluorescence can help doctors quickly identify which emergency patients with infections are at risk for severe sepsis, septic shock, or organ failure. Researchers will compare the test results to standard metho…

This study looks at whether intensive care nurses can learn to use a special ultrasound method called VExUS to find early signs of vein congestion in people with sepsis. Sepsis can cause blood to back up in veins, harming organs. The study will train nurses, check how well they p…

This study will collect information from 10,000 people across Saudi Arabia who need emergency abdominal surgery. Researchers want to understand what affects recovery and survival, and use that knowledge to improve care and create national standards. No new treatments are being te…

This study will follow 20,000 older adults having noncardiac surgery to see if a wearable device can detect early signs of serious complications like heart injury, bleeding, and infections. Researchers will use the data to build prediction models and create a biobank for future t…

This study will look at blood and urine samples from 1400 ICU patients to find better ways to diagnose sepsis early and predict who is at highest risk. Researchers will analyze genetic and protein markers to create a rapid test and a risk scoring system. The goal is to help docto…

This study will observe 400 adults with sepsis (a severe infection) who need medication to keep their blood pressure up. Researchers will check their heart function and blood vessel health within 72 hours of hospital admission. The goal is to see if certain patterns of heart and …

This study looks at a new device that can measure a substance called nucleosomes in the blood right at the patient's bedside. Researchers want to see if these levels can help predict which critically ill patients will survive for 30 days. The study will include 130 adults in the …

This study observes 200 adults with sepsis in intensive care units across four countries. Researchers will use regular heart ultrasound (echocardiography) and blood pressure measurements to see if certain heart function tests can better predict serious outcomes like death. The go…

This study will look at 10,000 adults in intensive care units (ICUs) worldwide during a single day to understand how common infections are and how they are treated. Researchers will collect information from medical records about infections, antibiotic use, and patient outcomes. N…

This study looks at 180 adults with sepsis-related acute respiratory distress syndrome (ARDS), a severe lung condition. Researchers will collect fluid from the lungs and blood samples over three days to measure inflammation and injury markers. The goal is to identify different pa…

This study looks at special molecules called SPMs that help the body turn off inflammation naturally. Researchers will measure SPM levels in blood samples from 300 ICU patients with severe infection or sepsis. No new treatments are given—only standard care. The goal is to see if …

This study tests whether wearable sensors can predict sepsis in intensive care patients. About 360 adults at risk of sepsis will wear devices that track vital signs and sweat lactate for up to 48 hours. The goal is to use this data to train artificial intelligence models that cou…

This study will collect information from 1,200 patients in the French West Indies and Guiana who have received ECMO, a machine that helps the heart and lungs work. The goal is to understand how these patients fare, including survival rates and complications. No new treatments or …

This study aims to create and test a tool to quickly recognize sepsis in children under 18 across hospitals in Asia. Researchers will check a new scoring system in 40,000 kids with suspected infections to see how well it predicts death and serious illness. The goal is to give doc…

This study follows 150 older adults (age 40+) who survived a stay in the intensive care unit (ICU) for sepsis or acute lung injury. Researchers will measure muscle strength and physical function at hospital discharge and again at 3, 6, 12, and 24 months. In a small group, muscle …

This study follows 40 adults with serious burns to collect blood, tissue, and medical data. Researchers will look for patterns that could help predict sepsis and other complications. The goal is to build computer models that improve burn care and outcomes.

This study will look back at medical records of 1,600 patients with liver cirrhosis who also have sepsis, a life-threatening infection. Researchers want to see how different treatments, like fluids and antibiotics, affect survival 28 days later. The goal is to find better ways to…

This study follows 80 adults with serious burns to collect blood, tissue, and medical record information. Researchers will look for patterns that could help predict who is at higher risk for infections like sepsis or other complications. The goal is to use this data to build comp…

This study looks at whether simple signs of blood flow to the skin, like how fast color returns after pressing a nail, are linked to recovery in adults with sepsis in the ICU. Researchers will collect routine data and blood tests on the first day only, with no extra procedures. T…

This study aims to find the best way to dose the antibiotic ceftazidime for patients in intensive care with serious infections. Standard dosing often leads to levels that are too low or too high. Researchers will test a personalized dosing plan based on each patient's kidney func…

This study will test whether an artificial intelligence (AI) tool, similar to ChatGPT-5, can help doctors make better decisions for critically ill patients in the intensive care unit (ICU). About 1000 adults will be randomly assigned to either standard care or care where doctors …

This study will test whether dapagliflozin, a diabetes medicine, can reduce inflammation in adults with sepsis. Researchers will measure changes in an inflammatory marker called IL-10 and compare it to HDL cholesterol to see which better predicts organ failure and death. The goal…