SEPSIS

This early-stage study is testing a new drug called OPT101 in adults hospitalized with pneumonia that has led to sepsis, a life-threatening body-wide infection. The main goal is to check if the drug is safe and how the body processes it. About 26 participants will receive either …

This study looks at whether giving a common antibiotic (beta-lactam) through a longer, continuous drip works better than giving it in shorter, separate doses for adults with severe infections (sepsis or septic shock) in the intensive care unit. Researchers will follow 50 patients…

This study is testing whether curcumin, the active compound in turmeric, can help control the dangerous immune overreaction in patients with severe sepsis. Fifty-six critically ill patients will receive either curcumin or a placebo pill in addition to all their standard hospital …

This study aims to improve survival for adults with HIV who develop life-threatening sepsis in sub-Saharan Africa. Researchers are testing whether adding a steroid (hydrocortisone) and a stronger combination of antibiotics to the current standard treatment helps more people survi…

This study aims to find the best way to give antibiotics to critically ill children with severe infections like sepsis. Researchers will compare giving the same antibiotic dose over 3 hours versus the standard 30 minutes to see if the longer infusion works better to clear the inf…

This study aims to find the best blood purification method to help children with severe sepsis. Researchers will compare three different filtering techniques to see which one best reduces harmful inflammation in the body and improves survival. The trial will include 120 children …

This study is testing whether a daily food supplement containing a specific pasteurized gut bacteria can help adults recover after being treated in the Intensive Care Unit (ICU) for sepsis. Researchers want to see if the supplement is safe to take for 56 days and if it improves t…

This study aims to find the best way to dose the antibiotic ceftazidime for critically ill patients in the ICU with severe infections like sepsis. Researchers will test if personalized dosing, adjusted for each patient's kidney function and other factors, is better than the stand…

This study is testing whether giving plasma (the liquid part of blood) can help protect and repair the lining of blood vessels in people with sepsis, a life-threatening infection response. Researchers will compare plasma given in different ways against a placebo fluid in 45 adult…

This study is testing if adding a drug called MEX-CD1 to dialysis fluid can safely remove excess iron from the blood of ICU patients with severe kidney failure caused by sepsis. Fourteen participants will receive two 24-hour dialysis sessions—one standard and one with the added d…

This small pilot study aims to see if adding a drug called fludrocortisone to standard treatment helps patients survive septic shock, a deadly condition where infection causes dangerously low blood pressure. The study will involve 32 critically ill patients in intensive care unit…

This study aims to find out if one common IV fluid is better than another for the initial emergency treatment of sepsis, a life-threatening infection response. Researchers will compare Ringer's lactate solution to normal saline in 88 adult patients to see which fluid leads to bet…

This study aims to see if starting a blood pressure medication called norepinephrine very early in treatment helps adults survive septic shock, a life-threatening condition. Researchers will compare giving the medication quickly with adjusting the dose every 15 minutes to the sta…

This study tests two different phone-based follow-up strategies to help adult sepsis patients survive the critical 90 days after leaving the hospital in Sub-Saharan Africa. Researchers will compare standard follow-up care against standard care plus automated phone check-ins to se…

This project tests whether using a standardized 1-hour checklist for treating sepsis can save more lives. It will compare outcomes for about 120 patients treated before and after the new protocol is introduced at a hospital's emergency and intensive care units. The goal is to get…

This trial is testing a personalized treatment plan for adults hospitalized with severe infections like sepsis. The goal is to prevent organ failure by quickly identifying and treating specific problems in the lungs, heart, liver, blood, or immune system. Researchers will compare…

This study is testing whether Racecadotril, a drug typically used for diarrhea, can help protect organs in patients with sepsis—a life-threatening body-wide infection. Researchers will give 44 sepsis patients either Racecadotril or a placebo (inactive substance) through a feeding…

This large international trial aims to find better, personalized treatments for sepsis, a life-threatening response to infection. It will enroll 2,000 children and adults to test multiple treatments at once, matching them to a patient's specific biological traits. The goal is to …

This study aims to see if dapagliflozin, a drug typically used for diabetes, can reduce harmful inflammation in patients with sepsis, a life-threatening body-wide infection. Researchers will give the drug or a placebo to 64 adults in the ICU and measure specific markers in the bl…

This study aims to develop and test a computer software tool that uses artificial intelligence (AI) to help doctors detect sepsis earlier in children arriving at emergency departments. The tool analyzes a child's electronic health records along with results from a special panel o…

This study is testing two new computer-generated risk scores designed to give doctors an early warning. One score predicts a patient's risk of developing sepsis in the next four hours, and the other predicts their risk of serious deterioration, like needing ICU care. The goal is …

This study is testing whether intensive care unit (ICU) nurses can learn to use a specific type of bedside ultrasound, called VExUS, to reliably check for blood congestion in the veins of sepsis patients. Sepsis is a severe reaction to infection that can cause organ damage, and e…

This study aims to find better ways to detect kidney injury early in adults with sepsis, a life-threatening infection. Researchers will test if a special kidney ultrasound and a urine test can spot signs of kidney stress before standard blood tests show a problem. The goal is to …

This study aims to create and test a new early warning system to help doctors identify sepsis in children faster and more accurately. It will involve 40,000 children under 18 across Asia who are hospitalized with a suspected infection. The goal is to validate a scoring system and…

This study is testing a new device that sends mild electrical signals to the thigh muscles of people in the Intensive Care Unit (ICU). The goal is to see if using the device is safe and practical, and if it can help slow down the severe muscle weakness that often develops in crit…

This study aims to see if simple signs of blood flow to the skin, like how quickly color returns after a gentle press, are linked to how well people with sepsis recover in the intensive care unit. Researchers will observe 80 adult patients with sepsis, collecting routine data and…

This study aims to understand and predict serious complications that can happen after surgery in people aged 65 and older. Researchers will enroll 20,000 patients and monitor their vital signs continuously for 30 days after their operation using a wearable sensor. The goal is to …

This study aims to better understand what happens to sepsis patients after they leave the hospital. Researchers will follow 760 adult patients in Brazil for one year after their hospital stay to track their recovery, quality of life, and any complications. This is an observationa…

This study aims to understand how sepsis (a severe infection) changes the immune system's activity over time. Researchers will follow 290 people—including sepsis patients, other critically ill patients, and healthy volunteers—for up to 12 months after their ICU stay. By analyzing…

This study aims to understand how kidney dialysis machines filter a common antibiotic (piperacillin-tazobactam) out of the blood of intensive care patients with severe infections. Researchers will measure drug levels in 24 ICU patients who are on dialysis and receiving this antib…

This is a small pilot study to see if it's practical to give a written education brochure to adults who survived sepsis in the Intensive Care Unit (ICU). Researchers want to know if they can successfully recruit patients and deliver the brochure. They will compare patients who ge…

This study aims to better understand how heart and blood vessel problems affect people with severe sepsis. Researchers will observe 400 adults hospitalized with sepsis who need medication to support their blood pressure. They will perform heart ultrasounds, blood tests, and check…

This study aims to test whether a new scoring system (SOFA-2) can better predict which ICU patients with sepsis will survive. Researchers will collect routine medical data from 2,500 adult ICU patients across Turkey to compare the new score against the old one. The study will als…

This study aims to find the best computer tool for spotting sepsis early by comparing three different prediction algorithms. The tools will run quietly in the background of hospital records for 1,200 adult patients arriving at the emergency department, without doctors or patients…

This study aims to understand what causes anemia in newborns admitted to intensive care and how it affects their health. Researchers will observe 40 infants to identify risk factors and track outcomes like hospital stay length and need for blood transfusions. The study does not t…

This study aims to create a computer model that predicts which sepsis patients have antibiotic-resistant infections. Researchers will analyze data from 10,000 adult patients with sepsis at a Buenos Aires hospital to identify patterns and risk factors. The goal is to help emergenc…

This study aims to understand why some older adults don't fully recover their strength and mobility after surviving a serious illness like sepsis or acute lung injury. Researchers will follow 150 patients aged 40+ for two years after hospital discharge, measuring their muscle str…

This study aims to understand why patients with sepsis-related severe lung failure (ARDS) have such different outcomes despite similar appearances. Researchers will closely monitor 180 patients during their first 72 hours of treatment, collecting fluid samples from their lungs an…

This study aims to learn how the body's natural inflammation-resolving molecules change in adults with severe infections in the ICU. Researchers will measure these molecules in blood already taken for routine care from about 300 patients to see if their levels can help identify p…

This study aims to see if sending supportive messages helps people recovering from sepsis share their health information from home. Researchers will compare 200 patients who get these messages to those who don't, to see who is better at providing data. The goal is to learn how to…

This study aims to understand how common and serious infections are in intensive care units (ICUs) worldwide. Researchers will collect information from 10,000 adult ICU patients across the globe during a single day to see what types of infections occur, how they're treated with a…

This study aims to learn if specific patterns of immune cells in the blood can predict outcomes for adults with severe infections (like sepsis) in the ICU. Researchers will collect small blood samples from 200 participants during their ICU stay and review their medical records, w…

This study aims to understand how well current treatments work for people with liver cirrhosis who develop a life-threatening bloodstream infection called sepsis. Researchers will look back at the medical records of 1,600 patients to see which treatment approaches were linked to …

This study aims to see if a simple calculation using heart rate and blood pressure, called the Modified Shock Index, can help doctors better predict how sick a sepsis patient will become. Researchers will enroll 70 adults arriving at the emergency department with sepsis to test t…

This study aims to better understand how the body recovers from serious burns and to identify early warning signs for dangerous infections like sepsis. Researchers will follow 80 adult patients with major burns, collecting small blood samples and reviewing their medical records d…

This study aims to see if a new, quick bedside blood test can predict which critically ill patients are most likely to die within 30 days. Researchers will enroll 130 adults in the ICU with severe conditions like sepsis, shock, or major trauma. They will compare the new finger-pr…

This study creates a registry to track outcomes for patients receiving ECMO life support in the Caribbean region. It will follow 1,200 patients with severe heart or lung failure who need this advanced treatment. The main goal is to understand survival rates and complications to i…

This study is testing whether an AI assistant can help doctors make better decisions for critically ill patients in intensive care. About 1000 adult ICU patients will be randomly assigned to receive either standard care or care where doctors can see AI suggestions. Researchers wi…

This national study will collect information from 10,000 emergency abdominal surgery patients across Saudi Arabia to understand current outcomes and identify ways to improve care. Researchers will review medical records to track complications, recovery times, and survival rates a…

This study follows adults with serious burns to understand how their bodies recover and identify who might develop dangerous infections like sepsis. Researchers will collect small blood and tissue samples along with medical record information to look for patterns. The goal is to …

Norwegian guidelines for empirical antibiotic therapy in suspected community acquired sepsis recommend the combination of narrow spectrum betalactam and aminoglycoside as the first choice, but broad spectrum betalactams are considered equally appropriate, effective, and safe. How…