SEPSIS

This study tests a drug called emapalumab in adults with sepsis who have a specific immune pattern (high interferon-gamma). The drug blocks this signal to see if it helps patients recover faster in the ICU. About 75 people will take part, and the study compares two different dose…

This study looks at 400 burn patients with sepsis to see if one type of antibiotic (carbapenems) works better than another (noncarbapenem beta-lactams) for initial treatment. The main goal is to compare survival rates using a standard severity score. The research is currently act…

This study was designed to test a new combination treatment for adults in the ICU with severe pneumonia, often complicated by sepsis or lung failure. The goal was to see if adding the experimental drugs to standard care could lower the chance of death within 28 days. However, the…

This study aimed to see if adding two immune therapies—a drug called nogapendekin alfa inbakicept and special immune cells (iNKT cells)—to standard care could help critically ill adults with severe pneumonia, sepsis, or lung failure recover. It was designed for adults in the ICU …

This study tests a new finger-clasp device, called Lab Clasp, that measures lactate levels from skin fluid instead of blood. High lactate can signal sepsis, a life-threatening infection. The goal is to see if the device works as well as standard blood tests in 6 healthy adults, m…

This study looks at whether a blood test called Monocyte Distribution Width (MDW) can help doctors quickly identify patients with bloodstream infections (bacteremia) in the emergency department. Researchers will check how well MDW levels predict positive blood cultures in 50,000 …

This early-phase study tests whether low doses of inhaled carbon monoxide are safe for people with severe lung injury caused by sepsis or pneumonia. Only 5 adults will receive the gas through a breathing mask, and researchers will closely monitor side effects. The goal is to see …

This study looks at whether esketamine, a drug related to ketamine, can safely sedate and prevent delirium in 80 adults with sepsis who need a breathing machine. Sepsis is a severe infection that can cause organ failure, and current sedatives have side effects like breathing prob…

This study compares treatment recommendations made by an artificial intelligence (AI) system to those made by real doctors for patients with sepsis and acute respiratory distress syndrome (ARDS). About 350 critical care doctors and advanced practice providers will review patient …

This pilot study at St. Jude Children's Research Hospital tests whether a heart MRI can be done safely within 10 days after sepsis in children with cancer, without needing anesthesia. It aims to find hidden heart inflammation or weakness that could affect recovery. The results wi…

This study is looking for markers in blood, stool, saliva, and lung fluid that might help doctors predict which patients with sepsis will have worse outcomes. Researchers will study 200 adults with suspected sepsis to see if a substance called resistin, along with other clinical …

This study looks at whether a structured nutrition plan can help ICU patients recover better after abdominal surgery. About 300 adults will receive a special feeding method that includes tube feeding, supplements, and a device to measure their exact calorie needs. The goal is to …

This study aims to find out how many adult patients in Turkish intensive care units have sepsis or septic shock, and what happens to them over the next 30 days. Researchers will collect data from hospitals across Turkey between September 2025 and January 2026. The goal is to prov…

This study looks at how much older adults move while in the intensive care unit (ICU) for a critical illness like sepsis or respiratory failure. Researchers want to see if more activity during the hospital stay leads to fewer disabilities and better physical and mental function 3…

This study aimed to see if sending supportive messages to sepsis survivors after hospital discharge would encourage them to regularly share health data through an online portal. The study was withdrawn before enrolling any participants, so no results are available. It was designe…

This study looks at blood markers in 90 adults with sepsis who develop confusion or delirium. Researchers measure specific proteins over 72 hours to see if they relate to brain injury and survival. No treatment is tested; the goal is to better understand and predict brain complic…

This study was designed to measure how stiff the arteries are in ICU patients receiving drugs to support their heart or blood pressure. Researchers planned to use a standard monitor to track this stiffness. However, the study was withdrawn before any participants were enrolled, s…

This study looks at how bacteria from dental treatment can help find better ways to detect sepsis, a life-threatening condition. Researchers are studying 100 people with gum disease to see how bacteria enter the blood and affect the body. The goal is to develop tests that spot se…

This study was designed to explore whether problems with mitochondria — the energy centers of cells — play a role in causing heart damage in people with sepsis. Researchers planned to compare blood samples from sepsis patients and healthy volunteers. However, the study was withdr…

This study looks at how sepsis, a severe infection, can damage the heart. Researchers will monitor about 330 adults with septic shock in the ICU, using heart scans, blood tests, and other measurements. The goal is to find patterns that help doctors better diagnose and predict out…

This study tracks 120 patients who receive a left ventricular assist device (LVAD), a mechanical heart pump. Researchers want to see how often infections happen after surgery and how the immune system changes. The goal is to find clues that could help predict and prevent infectio…

This study planned to see if an artificial intelligence system could predict sepsis—a dangerous infection—in people recovering from abdominal surgery. Participants would have worn a simple, non-invasive device to track vital signs, and the AI would combine that data with medical …

This study tests whether using rapid diagnostic tests (BCID2, Reveal Rapid AST, and PCT) can help doctors choose the right antibiotics faster for patients with severe infections (sepsis). About 190 adults in Greek ICUs will be randomly assigned to either the new test-guided appro…

This study tests whether metformin, a common diabetes medicine, is safe and practical to use for treating acute kidney injury caused by sepsis. Researchers will enroll 80 intensive care patients to monitor side effects and see if the treatment can be given successfully. This is a…

This study looks at a gene called TRIM25 in blood cells from 65 hospitalized adults with and without sepsis. By comparing gene activity and inflammatory markers, researchers hope to find new ways to diagnose and treat sepsis. Participants give blood samples, and no experimental t…

This study uses data from 16,000 hospital patients to see if men and women, or younger and older adults, need different blood lactate thresholds to predict risk of death or serious illness. Researchers hope to improve how doctors identify high-risk patients with sepsis in the ICU…

This study looks at medical records from 10,000 people who had sepsis (blood poisoning) and blood clots in their veins (VTE) while in the ICU. Researchers want to see if a serious clotting disorder called DIC happened before the blood clots formed. No new treatments or tests are …

This study was designed to see if a device called LifeFlow® could deliver fluids faster and more safely to children with sepsis in the emergency room compared to the usual push/pull method. It planned to include 600 children under 19 years old, but the study was withdrawn before …