SEPSIS

This early-stage study is testing whether inhaling very low doses of carbon monoxide (CO) is safe and can help treat severe lung inflammation caused by sepsis or pneumonia. The gas is being given to a small number of critically ill patients who are on breathing machines. Research…

This study is testing whether metformin, a common diabetes medication, is safe and practical to use for treating sudden kidney failure caused by severe bloodstream infections (sepsis). Researchers will give metformin or a placebo to 80 adult patients in intensive care with sepsis…

This study is testing whether a drug called emapalumab can help patients with severe sepsis who have a specific overactive immune response. It involves 75 adults in Greece with sepsis from infections like pneumonia, comparing two doses of the drug against a placebo. The main goal…

This study planned to test if a device called LifeFlow® could deliver emergency fluids faster and more effectively than standard methods in children with sepsis. It aimed to enroll 600 children under 19 years old in the emergency room. The main goals were to see if the device hel…

This study is testing a structured plan for delivering nutrition to patients in the intensive care unit (ICU) after major abdominal surgery or trauma. The goal is to see if this careful feeding approach, which uses a device to measure calorie needs and includes tube feeding and s…

This study is testing a new strategy to manage severe infections like sepsis. It uses rapid tests to identify the specific germ causing the infection and its antibiotic resistance much faster than standard methods. The goal is to help doctors prescribe the most effective antibiot…

This study aims to find out which of two common types of powerful antibiotics works better as the first treatment for sepsis, a life-threatening infection, in patients with serious burns. It will compare how well patients survive and recover when given either Meropenem or Piperac…

This study is testing a new finger-clip device that measures lactate levels without needing blood draws. Lactate is a key marker that helps doctors monitor sepsis, a serious infection. Researchers are comparing the device's readings against standard blood tests in healthy volunte…

This study aimed to better understand how blood vessels respond to pressure changes in critically ill patients receiving medications to support their heart and blood pressure. Researchers planned to measure a specific value (Eadyn) from standard ICU monitors to see how it relates…

This study aims to understand why patients who receive a mechanical heart pump (LVAD) often get serious infections afterwards. Researchers will look back at the medical records of 120 patients to see how often infections occurred and check if changes in their immune system are li…

This study aims to see if an artificial intelligence (AI) system can give treatment advice for sepsis and ARDS that is as safe and appropriate as advice from a human doctor. It will enroll 350 critical care doctors and nurses to review patient cases and guess whether the treatmen…

This study aims to understand if the amount of physical activity a person gets while hospitalized for a very serious illness affects their long-term recovery. Researchers will closely monitor the activity levels of 312 older adults in the ICU and then check on their ability to pe…

This study aims to understand how common sepsis and septic shock are in intensive care units across Turkey. Researchers will collect data from 1,000 adult patients in ICUs to measure the number of cases and track patient outcomes for 30 days. The goal is to gather crucial informa…

This study investigates how bacteria enter the bloodstream during dental cleaning for gum disease. Researchers are using this as a model to identify better blood markers for detecting bacterial infections that can lead to sepsis. They are also studying the long-term effects on he…

This research study aims to identify biological markers in blood, saliva, stool, and other body fluids that can help predict which sepsis patients are most likely to have poor outcomes. Researchers will collect samples from 200 adult patients with suspected sepsis over several ti…

This study aims to understand how a specific gene, called TRIM25, behaves in the blood cells of people with sepsis compared to those without it. Researchers will collect blood samples from about 65 hospitalized patients to see if the activity of this gene is linked to how well pa…

This study aims to understand the relationship between sepsis (a life-threatening infection), dangerous blood clots (VTE), and a serious clotting disorder (DIC). Researchers will analyze the past medical records of 10,000 people who were in intensive care with sepsis and blood cl…

This study aims to better understand how heart problems affect patients with severe sepsis (septic shock) in the intensive care unit. Researchers will observe 379 adult patients to see if specific measurements of heart function and blood tests can predict who is more likely to su…

This study aims to understand why some sepsis patients develop sudden confusion or delirium, a condition linked to worse survival. Researchers will measure specific proteins in the blood of 90 emergency room patients with sepsis, comparing those with and without mental changes. T…

This study is testing whether a special heart scan (MRI) can be done safely and successfully in children with cancer who have recently recovered from a severe infection called sepsis. The goal is to see if these scans can find hidden heart problems, like inflammation or weakness,…

This study aimed to understand why sepsis, a severe body-wide infection, often damages the heart. Researchers planned to measure tiny energy-producing parts of cells (mitochondria) and markers of inflammation in the blood of sepsis patients. The goal was to see if these measureme…