SEPSIS

This study tested whether dobutamine, a heart-strengthening drug, could improve outcomes in people with septic shock and heart muscle weakness. 136 intensive care unit patients received either dobutamine or a placebo. The goal was to see if the drug reduced organ failure and impr…

This study looked at whether alpha-lipoic acid, a common antioxidant, can help critically ill patients with sepsis. 80 adults in the ICU were given either the supplement or a placebo for seven days. Researchers measured organ function and inflammation to see if the supplement imp…

This study tested whether giving very high doses of vitamin C to people with sepsis (a severe infection that can cause organ failure) could lower the chance of dying within 28 days. Over 200 adults in intensive care were randomly given either vitamin C or a placebo for up to 4 da…

This study tested a program called STAR, where a nurse helps sepsis patients for up to 90 days after they leave the hospital. The nurse checks for new health problems, adjusts medicines, and watches for complications. The goal was to see if this extra support reduces deaths and r…

This study tested the safety and how the body handles the antibiotic cefiderocol in 53 hospitalized children aged 3 months to 18 years with serious bacterial infections. The goal was to see if the drug is safe and how it works in the body. Results help doctors understand dosing a…

This study tested whether giving a medicine called noradrenaline before anesthesia can prevent dangerously low blood pressure in adults with sepsis who need emergency surgery. Researchers compared patients who received the infusion to those who did not, tracking complications lik…

This study tested whether using ultrasound to guide fluid therapy in sepsis patients leads to better outcomes. 118 adults in the ICU took part. The goal was to see if this precise approach reduces death rates and organ failure. Results could help doctors manage fluids more effect…

This study tested whether giving a concentrated protein solution (albumin) along with standard fluids is possible in patients with septic shock. 47 adults with severe infection and low blood pressure were enrolled. The main goal was to see if enough people could be recruited to r…

This study used artificial intelligence to find a set of proteins in the blood that can tell whether a fever is caused by bacteria or a virus. Researchers tested blood samples from 394 people with high fever and short illness. The goal is to create a quick test that helps doctors…

This study tested a new rapid test (OCEAN Dx) to identify bacteria in the blood of ICU patients with sepsis. The goal was to see if it works as well as standard blood cultures, which take 48-72 hours. A faster result could help doctors choose the right antibiotic sooner. The stud…

This study looked at whether a simple finger-prick test to measure lactate levels can help doctors identify patients with severe sepsis early, even before they are in the intensive care unit. The test is fast and easy to do at the bedside. 60 adults with signs of sepsis took part…

This study checked if a new type of blood culture bottle works as well as the current one for finding germs in the blood of people with suspected sepsis. About 394 patients gave blood samples that were placed into both the new and standard bottles. The bottles were then monitored…

This study tested whether a small, wearable device called Geko, which uses mild electrical pulses to stimulate leg muscles, can help prevent dangerous blood clots in critically ill adults. Forty intensive care patients were randomly assigned to receive either the Geko device or s…

This study looked at whether giving lactoferrin, a protein naturally found in breast milk, could help prevent sepsis (a severe blood infection) in premature babies. The study included 180 preterm infants with low birth weight. Researchers gave the babies lactoferrin by mouth to s…

This study tested whether a gentle massage technique called manual lymphatic drainage is safe and practical for patients recovering from septic shock. The goal was to see if it could help improve organ function and reduce complications. The trial involved 24 adults in the intensi…

This study looked at how well the body breaks down blood clots in 100 people with sepsis, a life-threatening infection. Researchers used a special test to measure clot breakdown time and compared it to healthy volunteers. The goal was to understand if a delay in clot breakdown is…

This study looked at 150 adults with sepsis in the ICU to find early warning signs in the blood that could predict a dangerous condition called DIC, where blood clots form throughout the body. Researchers checked for specific biomarkers and tracked patients for up to 56 days. No …

This study examined 16 ICU patients with sepsis to see if certain memory immune cells (called CD8+ T cells) are linked to how severe the infection is and the risk of dying. Researchers measured these cells in blood samples taken over 72 hours and tracked patient outcomes like len…

This study looked at 44 intensive care patients with septic shock to see how giving fluids changes blood flow in tiny vessels and affects organ function. Researchers measured capillary refill time (how fast skin color returns after pressing it) and organ failure scores before and…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out which patients are more likely to board, how boarding increases healthc…

This study looked at 350 adults with liver cirrhosis and sepsis-induced low blood pressure to find the best way to decide how much fluid to give. The goal was to see which method helps reach a safe blood pressure without causing fluid overload. The findings may improve care for t…

This study looked at 90 sepsis patients with low blood pressure to see if changes in blood vessel size during breathing could predict who needs extra fluids. Doctors often give fluids to improve circulation, but too much can be harmful. The goal was to find a simple, non-invasive…

This study looked at 192 adults with septic shock in the ICU. Researchers compared a simple bedside test (capillary refill time) with standard blood lactate levels to see which better predicts patient outcomes. They found that both prolonged capillary refill and high lactate leve…

This study looked at whether using an early heart ultrasound (echocardiography) in the emergency department can help guide treatment and reduce organ damage in adults with sepsis or septic shock. Researchers compared this approach to standard care based on current guidelines. The…

This study looked at medical records from over 5,700 adults in Japan who had sepsis (blood poisoning) to learn more about a serious complication called DIC, where blood clots form throughout the body. Researchers collected information on how many people developed DIC, how doctors…

This study looked at how certain immune cells, called antigen-presenting cells, work in people with sepsis, a severe response to infection. Researchers collected extra blood samples from 119 participants, including sepsis patients and healthy volunteers, to understand why some pa…

This study looked at 276 adults with sepsis in the ICU to see if a score called the CALLY index—based on routine blood tests—can predict who is at higher risk of dying within 30 days. Researchers also checked if changes in this score relate to kidney problems. No new treatments w…

This study looked at whether simple checklists (MEWS and qSOFA) and artificial intelligence can help predict sepsis in emergency room patients. Researchers reviewed medical records of 950 people who visited the ER between 2020 and 2022. The goal was to see if these tools could he…

This study looked at 567 intensive care unit patients to find early signs that predict serious complications from sepsis, a life-threatening infection. Researchers used advanced protein analysis on a smaller group and then checked a key protein (MMP-3) in all patients. The goal w…

This study looked at how high doses of the antibiotic ceftriaxone work in 20 adults with sepsis. The goal was to find the best dose to keep drug levels high enough to kill bacteria. Researchers used blood samples and computer models to see if the dose reached the target. The stud…

This study looked at whether certain white blood cells or platelet counts can predict early worsening in sepsis patients. Researchers followed 161 adults in the ICU, checking their blood and health for five days. The goal was to see which test better spots patients at risk of get…

This study tested a computer program that sorts sepsis patients into four groups based on their vital signs in the first 8 hours. The goal is to see if these groups have different outcomes, which could help design better treatments in the future. Over 1,900 adults participated, b…

This study looked at 56 patients in a French hospital who had infections from a rare type of Klebsiella pneumoniae bacteria that can be treated with the common antibiotic amoxicillin. Researchers analyzed the bacteria's DNA to understand why some strains are sensitive to amoxicil…

This study tested a handheld microscope to look at tiny blood vessels in 68 adults with sepsis or septic shock. The goal was to understand how these vessels break down during severe infection, which could help doctors design better treatments in the future. Participants were moni…

This study looked back at 200 ICU patients with septic shock to see if using a bedside ultrasound (POCUS) as part of routine care improved their outcomes. Researchers compared patients treated before and after the ultrasound program started. The goal was to see if ultrasound help…

This study looked at over 1,000 adults in Northeast Thailand who were hospitalized with sepsis caught outside the hospital. Researchers used the latest Sepsis-3 guidelines to understand what causes the infection and what factors affect whether patients survive. The goal was to le…

This study looked at whether sepsis causes immune suppression that makes ICU patients more likely to get pneumonia while on a ventilator. Researchers compared 50 patients with and without sepsis, measuring immune markers in blood and lung fluid over five days. The goal was to bet…

This study explored whether measuring the activity of a gene called Acod1 in blood cells can help predict which sepsis patients are at higher risk of dying. Researchers collected blood samples from 52 adults with sepsis within 24-48 hours of ICU admission and measured Acod1 level…

This study looked at whether three blood test ratios (lactate-to-albumin, CRP-to-albumin, and procalcitonin-to-albumin) can predict the risk of death in critically ill adults in the ICU. Researchers reviewed medical records of 212 patients admitted to an ICU in 2024. The goal was…

This study looked at how certain molecules in the body change when sepsis affects the heart. Researchers observed 567 adults in the intensive care unit to understand these changes better. The goal was to learn more about the condition, not to test a new treatment.

This study looked at whether giving higher doses of two common antibiotics (amikacin and gentamicin) helps critically ill patients with severe sepsis reach target drug levels in their blood. Researchers studied 63 ICU patients to see if the higher doses were effective. The goal w…

This study looked at whether changes in simple urine tests (white blood cells and nitrite) before kidney stone surgery can help predict serious infections like fever or sepsis afterward. Researchers followed 346 adults with large or complex kidney stones. The goal was to see if t…

This study looked at over 2,000 adults with sepsis in emergency rooms. Researchers used an algorithm based on vital signs to identify patients who might do better with balanced fluids instead of normal saline. The goal was to see if prompting doctors to use balanced fluids could …

This study looked at two blood markers—nCD64 and mHLA-DR—in 76 adults with septic shock, a life-threatening infection that can cause organ failure. Researchers took blood samples on day 1 and day 8 to see how these markers changed over time and whether they could tell apart survi…

This study looked at 30 intensive care patients with septic shock to see how a drug called norepinephrine affects both large and tiny blood vessels. Doctors already use a measure called ScvO2 to check large blood vessels, but they wanted to see if a new tool measuring tissue oxyg…

This study examined whether the initial diagnosis given to patients when they enter the ICU can help predict their risk of dying. Researchers reviewed records of over 1,200 adults admitted to a mixed ICU in 2025. They focused on common critical conditions like sepsis, ARDS, and o…

This study looked at 150 adults with sepsis to see if a score called EASIX (based on routine blood tests) could predict who would die or have serious complications within 28 days. Researchers measured the score at the time of diagnosis and tracked outcomes like septic shock and k…

This study looked at whether a new scoring system called the Phoenix score can predict how well children with sepsis will do. Researchers compared it to older scoring methods in 25 children. No treatments or extra tests were given—just observation to see which score best predicts…

This study tested whether an artificial intelligence system could give doctors quicker feedback on how well they followed sepsis treatment guidelines. Sixty-six emergency room doctors were split into two groups: one got near real-time AI feedback, the other got standard delayed r…

This study examined blood clotting issues in 175 hospitalized COVID-19 patients. Researchers measured how well the blood forms clots (thrombin generation) to see if these tests could predict survival. The goal was to better understand why severe COVID-19 causes dangerous clotting…

This study examined whether a blood test called the Systemic Immune-Inflammation Index (SII) can help predict the risk of death in critically ill patients in the intensive care unit (ICU). Researchers looked back at the records of 570 adults admitted to the ICU. They found that h…

This study tested a program to help adults recover after sepsis, a serious infection that can cause organ failure. Researchers worked with 1,820 patients at high risk of returning to the hospital. The program focused on supporting patients after they left the hospital to improve …

This study tested a small wearable patch called TempShield that sticks to the chest and continuously checks body temperature in children ages 1 to 4 in the emergency room. The goal was to see if it could detect fevers earlier than standard thermometers. 72 children took part, and…

This study tested whether combining albumin levels with other blood markers (like CRP, procalcitonin, and lactate) could better predict which sepsis patients in the surgical ICU are at higher risk of dying within 28 days. Researchers looked at data from 30 patients to see if thes…

This study looked at 30 adults with sepsis to understand how changes in tiny blood vessels under the tongue relate to blood clotting problems. Researchers measured blood vessel health, oxygen levels, and clotting factors. The goal was to learn more about these connections, not to…

This study examined whether low magnesium levels are connected to blood clotting problems in people with sepsis, a serious infection. Researchers observed 150 adults in the intensive care unit to see if low magnesium increased the risk of a severe clotting condition called dissem…

This study looked at 130 adults who came to the emergency department with suspected sepsis. Researchers compared two scoring systems, REMS and NEWS2, to see which one better predicts how sick a patient might become, including need for intensive care, breathing machines, or risk o…

This study looked at whether a blood-filtering device called Efferon LPS removes antibiotics from the blood of people with sepsis. Sepsis is a severe infection that can lead to organ failure, and doctors sometimes use filters to help clean the blood. The goal was to measure how m…

This pilot study tested whether computer models could predict sepsis and a serious gut infection called NEC in very low birth weight infants (under 1500 grams). Researchers used existing NICU data from 144 babies to build and test these models. The goal was to see if such an earl…

This study followed 53 ICU patients who had a serious abdominal infection to understand why many become weak, frail, and disabled long after leaving the hospital. Researchers measured changes in frailty, muscle loss, and overall health at 3, 6, and 12 months. The goal was to defi…

This study looked at whether a protein called vasorin can help predict kidney injury and death in people with septic shock. Researchers measured vasorin levels in 50 intensive care patients. The goal was to see if higher vasorin levels are linked to worse outcomes, which could le…

This study looked at 147 people with kidney stones who had a positive urine culture before surgery. Doctors gave them antibiotics and checked their urine again to see if a negative culture was needed to prevent infections after surgery. The goal was to find out if waiting for the…

This study looked at whether a regional guideline for spotting and treating sepsis early helped pregnant or postpartum women in Italy. Researchers compared hospital stays, deaths, and complications in 52 women before and after the guideline was put in place. The goal was to see i…

This study looked at anonymous medical records from over 55,000 past ICU patients to find patterns that might help predict three life-threatening conditions: sepsis (a severe infection), ARDS (lung failure), and acute kidney injury. Researchers used computer models to see if they…

This study looked at 120 ICU patients to see if certain blood test results (monocyte distribution, monocyte-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio) could help doctors diagnose sepsis earlier. Researchers compared these new markers with standard tests. The goal wa…

This completed study looked at 1,529 intensive care unit patients to see if levels of a substance called procalcitonin (PCT) in the blood could help identify bloodstream infections and the type of germ causing them. Researchers measured PCT within 24 hours of taking a blood cultu…

This study looked at 400 ICU patients with sepsis and nutritional risk to find factors that predict death within 28 days. Researchers measured lab tests and physical assessments to identify early warning signs. The goal is to help doctors intervene sooner and improve patient outc…

This study looked at whether measuring a substance called procalcitonin in the blood can help doctors safely shorten the time newborns with late-onset sepsis need antibiotics. Over 500 babies born at 24 weeks or later were included. The goal was to see if using procalcitonin leve…

This study looked at whether common blood tests can help predict the risk of death in people with suspected sepsis in the intensive care unit (ICU). Researchers reviewed records from 250 adults to see if levels of certain markers like PCT, CRP, and lactate were linked to survival…

This study looked at 185 children with sepsis to find patterns in blood markers and genes that might predict a bad outcome. Researchers measured immune cells, proteins like C-reactive protein, and genetic variations. The goal was to create an algorithm that helps doctors identify…