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Scientists watch sepsis damage tiny vessels in real time

NCT ID NCT07404475

Knowledge-focused Sponsor: Università Politecnica delle Marche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at 30 adults with sepsis to understand how changes in tiny blood vessels (microcirculation) relate to blood clotting problems. Researchers used a special microscope to view blood vessels under the tongue and measured clotting factors. The goal was to see if patients with clotting issues had worse vessel damage. No treatments were given; this was purely an observation study.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better understand how sepsis damages small blood vessels and causes clotting issues, potentially guiding future treatments.
What could go wrong
This is a small, observational study with only 30 participants. It does not test any treatment, so it cannot directly improve patient care. Results may not apply to all sepsis patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

30 people

The number who actually took part.

Started

Jun 2023

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

adult patients with sepsis or septic shock admitted to a 14-bed medical Intensive Care Unit

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * adult (\>18 years of age) * sepsis or septic shock Exclusion Criteria: * sepsis for more than 24 hours * pre-existing coagulopathy * concurrent use of therapeutic anticoagulation or thrombolytic agents * factors impeding the sublingual microvascular assessment * pregnancy * inability to obtain informed consent

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Conditions

The condition(s) this trial relates to.

blood coagulation disease infectious disease with sepsis Sepsis vascular hemostatic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coagulopathy Sepsis

Contacts and locations

Locations

  • Azienda Ospedaliero Universitaria delle Marche

    Ancona, 60126, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.