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Ultrasound may help avoid fluid overload in sepsis

NCT ID NCT03066362

Knowledge-focused Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether ultrasound measurements of the vena cava and femoral artery can predict which sepsis patients with low blood pressure will benefit from extra fluids. 90 spontaneously breathing adults in intensive care were studied. The goal is to avoid giving too much fluid, which can be harmful.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could give doctors a simple, non-invasive way to decide which sepsis patients need fluids, reducing harm from overhydration.
What could go wrong
This is a small, completed observational study, not a treatment trial. The findings may not apply to all patients or change practice without larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Start date

Nov 2011

Finished

Feb 2014

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients of the intensive care units of the Lille university-hospital and of the Valenciennes general hospital. * Age greater than or equal to 18. * Patient insured * Spontaneous breathing without ventilatory support or intubation or tracheotomy. * Regular cardiac rhythm * Prescription by the physician in charge of the patients of a 500 mL volume expansion in less than 30 minutes. * Patients with sepsis with at least one sign of acute circulatory failure: * Tachycardia with heart rate\> 100/min * systolic blood pressure \<90mmHg or a decrease \>40mmHg in previously hypertense patient * Oliguria \<0.5ml/kg/hour for at least one hour * skin mottling Exclusion Criteria: * high-grade aortic insufficiency * transthoracic echogenicity unsuitable for measuring the stroke volume or inferior vena cava diameters * clinical signs of active exhalation * clinical or ultrasonographic evidence of pulmonary edema due to heart failure * pregnancy * abdominal compartment syndrome * Irregular cardiac rhythm

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Conditions

The condition(s) this trial relates to.

cardiac arrest infectious disease with sepsis Sepsis Shock

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Circulatory failure Respiratory physiological phenomena Sepsis

Contacts and locations

Locations

  • Intensive Care Department, Salengro Hospital, CHU de Lille

    Lille, Hauts-de-France, 59000, France

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