University Hospital, Lille

This study tests if bariatric (weight-loss) surgery is more effective than standard medical treatment at making nonalcoholic steatohepatitis (NASH) disappear without worsening liver scarring. It involves 100 obese adults with advanced liver fibrosis. Participants are randomly ass…

This study tests whether a quick blood test can detect leaks around a new heart valve during a minimally invasive procedure. About 944 people with severe aortic stenosis will participate. The goal is to improve outcomes by catching leaks early without needing general anesthesia o…

This study looks at whether adding a mesh at the back of the vagina during standard prolapse surgery can stop the problem from returning. About 834 women with moderate prolapse (but not severe back-wall prolapse) will be randomly assigned to get either the standard front mesh or …

This study compares two versions of gastric bypass surgery in severely obese people with type 2 diabetes. The goal is to see which method leads to diabetes remission, meaning blood sugar stays normal without diabetes drugs. About 396 participants will be randomly assigned to one …

This study looks at whether keeping the umbilical cord intact while helping a newborn breathe (instead of clamping it right away) improves heart and lung function in full-term babies born with a rare hole in the diaphragm called congenital diaphragmatic hernia (CDH). About 180 ba…

This study tests a new device called PAGETEX that uses light therapy (photodynamic therapy) to treat vulvar Paget's disease, a rare skin condition that often comes back after surgery. About 24 women with non-invasive or recurrent disease will receive the treatment to see if it ca…

This study tests a two-step procedure for people with pancreatic or related cancers who are at high risk of complications from standard surgery. Instead of the usual partial pancreas removal, surgeons remove the entire pancreas and transplant the patient's own insulin-producing c…

This study tests a new way to follow patients after weight-loss surgery. Instead of regular clinic visits, patients use a connected scale at home to track their weight. The care team then adjusts follow-up based on the results. The goal is to help more patients maintain healthy w…

This study looks at whether draining large ovarian cysts (6 cm or bigger) caused by endometriosis, followed by hormone therapy, can lower the chance of cysts coming back and protect fertility. About 62 women will take part. The goal is to find a better treatment that avoids surge…

This study tests whether a step-by-step care plan (algorithm) can lower the chance of another serious bleed in people with von Willebrand disease. It compares the new plan to standard care in 66 adults who have had a gastrointestinal bleed or severe nosebleed. The goal is to see …

This study looks at whether having surgery to remove deep endometriosis in the bowel before IVF helps women with infertility get pregnant. About 120 women will be randomly assigned to either surgery plus IVF or IVF alone. The main goal is to see how many achieve a clinical pregna…

This study tests whether giving focused radiation before surgery for a single liver cancer nodule is safe and does not delay or cancel the planned operation. About 30 participants will receive radiation followed by surgery. The goal is to see if this approach can reduce the risk …

This study follows 900 adults with severe chronic sinusitis and nasal polyps who are taking biologic drugs. Researchers will track how well the drugs control symptoms and improve quality of life over 5 years. The goal is to see which patients benefit most and how safe the treatme…

This study tests whether adding a healthy gut bacteria (EXL01) to the immunotherapy drug nivolumab can help control advanced non-small cell lung cancer that has stopped responding to standard treatments. About 21 adults whose cancer progressed after prior therapies will receive t…

This study tests whether adding myo-inositol (a natural supplement) to the standard ovulation drug clomiphene citrate helps women with polycystic ovary syndrome (PCOS) ovulate more successfully. About 276 women who want to get pregnant will be randomly assigned to receive either …

This study tests whether the drug rapamycin can shrink large, hard-to-treat lymphatic malformations in the face and neck of children. About 28 kids aged 0 to 18 will take rapamycin by mouth for 6 months. The goal is to see if the malformations shrink by at least one-fifth, improv…

This study tests whether Diroximel Fumarate, a drug already used for multiple sclerosis, can reduce harmful brain swelling that often occurs after a bleeding stroke. The trial will enroll 192 adults who have had a stroke, giving the drug within 48 hours of symptoms. The goal is t…

This study looks at whether giving radiation therapy after a targeted drug (sonic hedgehog inhibitor) has fully cleared advanced basal cell skin cancer can stop the cancer from returning. About 65% of patients see the cancer come back after stopping the drug alone. The study will…

This study is for people aged 65 or older who have been newly diagnosed with multiple myeloma and cannot have a stem cell transplant. Researchers are testing two different drug combinations: teclistamab plus daratumumab, or teclistamab plus lenalidomide. The goal is to see if the…

This study looks at 300 adults with atrial fibrillation (an irregular heartbeat) who have had a brain bleed. It compares three approaches to prevent future strokes: taking blood thinners, using a device to close a part of the heart, or avoiding both. The goal is to find which opt…

This early-phase study tests whether a type of immunotherapy called CD19 CAR-T cells is safe for adults with a hard-to-treat form of acute myeloid leukemia (AML) that has returned or not responded to standard treatments. The therapy uses a patient's own immune cells, modified in …

This study tests whether a blood-filtering procedure called rheopheresis can help heal severe skin ulcers caused by calciphylaxis, a rare complication in people on dialysis. About 138 adults with end-stage kidney disease and at least one open ulcer will receive rheopheresis along…

This study looks at people with a rare type of stomach cancer called signet ring cell adenocarcinoma. It compares two treatment strategies: having surgery first, or having chemotherapy first followed by surgery. The goal is to see which approach helps people live longer and with …

This study tests a new treatment for a rare and aggressive lung cancer called malignant pleural mesothelioma. The treatment combines a light-activated therapy (photodynamic therapy) given during a procedure inside the chest, followed by an immunotherapy drug (nivolumab) that help…

This study is testing a new blood test to diagnose mucormycosis, a serious fungal infection that can be deadly if not treated quickly. Researchers will measure a specific sugar molecule from the fungus in blood samples from 100 people, including those with the infection and those…

This study aims to see if a short self-report questionnaire called T-ACE can correctly identify pregnant women who drink alcohol at risky levels. Researchers will compare the T-ACE results with a blood test that measures a biomarker of recent alcohol use. About 2,425 pregnant wom…

This study looks for a specific immune problem called SPAD in adults aged 18-65 who have had unexplained, frequent, or severe bacterial respiratory infections for at least two years. Participants will receive a special vaccine to test their immune response. The goal is to better …

This study is testing whether two substances in the blood, called TFPI-1 and TFPI-2, can tell apart people with colorectal cancer from healthy individuals. About 303 adults aged 50 to 75 will take part. If successful, this could lead to a simpler, less invasive way to screen for …

This study tests a simple scale that general practitioners can use to spot frailty in independent seniors over 65. Frailty means increased weakness and risk of falls or hospital stays. The goal is to catch it early so doctors can help patients stay healthy longer. About 740 peopl…

This study tests a new technique where doctors gently press on the side of the neck to block the esophagus during mask breathing in children under anesthesia. The goal is to prevent air from entering the stomach, which can cause complications. The study involves 72 children aged …

This study compares a newer surgery called TOETVA, which removes the thyroid through the mouth leaving no visible scar, to the standard neck incision surgery. About 616 adults needing thyroid removal will be randomly assigned to one of the two procedures. The main goal is to see …

This study tests a new shoe called CHUT OTONOM® designed to improve walking stability and reduce fall risk in people aged 65 and older who have fallen at least once in the past six months. Researchers will compare walking speed and other gait measures when wearing the special sho…

This study tests whether people with schizophrenia can learn to quiet their auditory hallucinations using real-time brain scans (fMRI). Participants see their own brain activity and try to shift it toward a non-hallucinating state. The trial involves 84 adults whose hallucination…

This study tests a tool called PARKINSUN that helps Parkinson's patients talk better with their doctors. About 120 adults with Parkinson's will either use the tool or not during checkups over 7 months. The goal is to see if it improves patient satisfaction and makes care more foc…

This study tests whether taking caffeine for 30 weeks can slow down memory and thinking problems in people with early-to-moderate Alzheimer's disease. About 248 participants will receive either caffeine pills or a placebo (dummy pill) to see if caffeine helps keep their minds sha…

This study tests a non-invasive device that stimulates a nerve in the leg to improve bladder emptying in people with multiple sclerosis. 68 participants who currently use a catheter to empty their bladder will be randomly assigned to receive either real stimulation or a placebo f…

This study looks at whether endoscopic sinus surgery can improve sleep problems in people with chronic rhinosinusitis and nasal polyps. About 30 adults who have not responded to medication will have their sleep measured before and 3 months after surgery. The goal is to see if rem…

This study tests a new device called BUBOLight® that uses soft fabric strips with lights to treat jaundice in newborns. Jaundice is common and usually harmless, but high bilirubin levels can be dangerous. The study will include 15 babies who need light therapy and will check if t…

This study tests whether virtual reality (VR) therapy can help people with gambling disorder reduce their cravings and gambling behavior. About 124 participants will receive either standard talk therapy or VR therapy that simulates a casino environment. The goal is to see if VR t…

This study looks at how spinal anesthesia, given during planned C-sections, affects the baby's nervous system. Researchers will monitor the baby's heart rate before and after the anesthesia to measure stress. The goal is to better understand any risks to the baby, not to test a n…

This study is creating a national group of 600 people with chronic high levels of eosinophils (a type of white blood cell) or related organ damage. Researchers want to understand the different symptoms, how the disease changes over time, and what genetic or environmental factors …

This study aims to find better ways to monitor the harmful effects of chronic nitrous oxide (laughing gas) use, which can cause nerve damage and walking problems. Researchers will measure specific blood markers in 356 current or former users, with or without symptoms. The goal is…

This study looks at a rare but serious drug allergy called DRESS syndrome. Researchers want to understand how certain immune cells (eosinophils) contribute to the disease. They will compare 80 participants with DRESS, other drug rashes, and healthy volunteers. The goal is to find…

This study tests whether a phone-based check-in system can improve recovery for women who have experienced violence. After a forensic medical exam, some women will receive follow-up phone calls and a postcard, while others get standard care. Researchers will track PTSD symptoms a…

This study will follow 1,000 critically ill patients in European ICUs to see if those with weakened immune systems (immunocompromised) are more or less likely to pick up or get infected with multidrug-resistant bacteria. Researchers want to confirm earlier findings that isolation…

This study compares standard 2D X-ray guidance with a 3D imaging technique called OCT during leg artery procedures. About 166 adults with blocked leg arteries will be randomly assigned to one of two groups. The goal is to see if OCT helps doctors place balloons and stents more ac…

This study observes heavy drinkers who develop jaundice to learn how common alcoholic hepatitis is and what affects their survival. Researchers will collect genetic samples and track liver function over 12 months. The goal is to better understand the disease and improve diagnosis…

This study is testing whether cameras, microphones, and wearable sensors can help doctors measure how severe a person's depression is. Researchers will record interviews with 300 hospitalized patients and analyze facial expressions, voice, movement, heart rate, and brain activity…

This study is testing a simple food questionnaire called EvalSel to see how well it measures salt intake in hospitalized patients with high blood pressure or kidney disease. Researchers will compare the questionnaire results with a 24-hour urine test, which is the standard way to…

This study looks at how sacral neuromodulation (a nerve-stimulating implant) changes the autonomic nervous system in people with overactive bladder. Researchers will measure heart rate variability in 40 adults during the implant procedure to see if certain nerve responses can pre…

This study follows 1500 adults who are scheduled for heart surgery or a less invasive valve procedure. Researchers want to learn what factors predict major heart problems like stroke, heart failure, or death after the procedure. Participants will be monitored for several years to…

This study looks at inflammation and healing markers in people with alcoholic liver disease. Researchers will compare three groups: those with alcoholic hepatitis, those with alcoholic cirrhosis, and healthy people without liver disease. The goal is to understand what drives seve…

This study follows 500 newborns from birth to age 4 to understand how breastfeeding affects gut health. Researchers collect stool samples and track digestive symptoms, focusing on a key immune marker called secretory IgA. The goal is to learn how early nutrition influences long-t…

This study looks at anxiety levels in men with low-risk prostate cancer who are on active surveillance (regular monitoring instead of immediate treatment) and their partners. Researchers will use questionnaires to measure anxiety and find out what factors might predict it. The go…

This study looks at adults with cystic fibrosis who are taking the drug combination ETI. Researchers want to find out how many of them have trouble breathing during a 6-minute walk test. The goal is to better understand how well the lungs work during exercise while on this treatm…

This study is testing a new, non-invasive way to predict bleeding risk in people with von Willebrand disease and other inherited bleeding disorders. Researchers will use a special microscope to look at tiny blood vessels under the tongue. The goal is to see if the density of thes…

This study looks at whether a toxin called deoxynivalenol (DON), often found in grains, might be an environmental risk factor for inflammatory bowel diseases like Crohn's and colitis. Researchers will measure DON levels in 100 people—some with Crohn's disease and some without—who…

This study aims to better understand systemic sclerosis, a rare disease that causes skin hardening and organ damage. Researchers will analyze skin and blood samples from 40 adults with the condition to see how different cell types interact. The goal is to find new clues for futur…

This study looks at whether exercise training can improve how well blood vessels work in adults with type 1 diabetes who do not yet have any diabetes-related complications. Researchers will measure changes in blood vessel function and related health markers. The goal is to find a…

This study aims to better predict the risk of death in people with metabolic diseases like diabetes, obesity, or metabolic syndrome who are already in hospital care. Researchers will analyze blood samples and health data from 10,000 participants to build a personalized risk profi…

This study explores whether a simple, noninvasive scalp exam called trichoscopy can help evaluate people with systemic scleroderma. Researchers will compare scalp images from 200 patients and healthy volunteers to see if certain features relate to organ damage or overall disease …

This study aims to find out how often adults with atopic dermatitis (eczema) have eyelid involvement, which can greatly affect quality of life. Researchers will track 550 patients in France, describing the type of eyelid eczema and looking for related factors like allergies or ot…

This study looks at how a focal seizure impacts attention in people with epilepsy. Researchers will test attention and brain activity before and at several points after a seizure. The goal is to understand how seizures disrupt attention networks, not to provide a treatment. About…

This study looks at how a single session of exercise changes brain-related chemicals in the blood and thinking skills in people who use cannabis regularly compared to those who don't. Researchers will measure endocannabinoids and other markers before and after exercise. The goal …

This study is creating a large database and biobank from 2200 people with chronic inflammatory diseases like lupus, multiple sclerosis, and severe asthma. Researchers will track disease activity, quality of life, and treatment responses over time. The goal is to find new markers …

This study looks at how learning about a baby's esophageal atresia before birth versus after birth affects parents' stress levels. Researchers will ask 240 mothers (and some fathers) about their traumatic reactions. The goal is to understand if earlier diagnosis helps or harms pa…

This study compares three types of hip replacement surgery to see which one best restores the hip's natural mechanics. Researchers will use CT scans and X-rays to measure how well each surgery rebuilds the hip joint. The study involves 165 adults who need hip surgery and will fol…

This study aims to see if measuring how much pelvic organs move during an MRI can help doctors better diagnose endometriosis and understand why some treatments don't work. Researchers will compare MRI scans taken at rest and while pushing to measure organ movement in 52 women wit…

This study looks at whether high pressure in the belly (intra-abdominal hypertension) causes more fluid to leak into the lungs of liver disease patients who are on breathing machines. Researchers will measure belly pressure and check lung fluid for signs of stomach contents. The …

This study looks at why teenagers who had surgery for a diaphragmatic hernia right after birth may or may not take part in sports and physical activities. Researchers will use surveys and interviews with 20 teens and their parents to find out what helps or hinders their activity.…

This study aims to understand how obesity and diabetes influence gene activity in tissues that process sugar and fat. Researchers will collect biological samples from 20,000 adults undergoing abdominal surgery. The goal is to learn how body weight and blood sugar levels change ge…

This study looks at how an inhaled drug called BGF 160 changes the way people with stable COPD breathe. Researchers want to understand the drug's mechanism by measuring breathing complexity and variability. About 35 adults aged 40-75 with moderate-to-severe COPD will participate.…

This study is looking for DNA markers that might predict the risk of silent strokes in older adults having a minimally invasive heart valve replacement called TAVR. Researchers will measure DNA methylation in blood samples before and after the procedure and compare it to brain sc…

This study follows 600 adults with type 2 diabetes who do not yet have heart failure or dementia. Researchers will track their health over time to find early warning signs of heart failure and cognitive decline. The goal is to learn how to better predict and prevent these complic…

This study looks at why some people with catatonia don't get better with the standard medicine lorazepam. Researchers will measure the drug's level in the blood after 3 days of treatment and check for genetic differences that might affect how the body processes the medicine. The …

This study looks at how social thinking skills (like understanding others' emotions) relate to real-life social behaviors in people with Alzheimer's or frontotemporal degeneration. Researchers will test 120 adults aged 40-85 using questionnaires and brain scans. The goal is to be…

This study follows 417 older adults (65+) with mild cognitive impairment (MCI) for one year to find out what factors predict falls. Participants will be tracked through diaries and monthly calls. The goal is to develop better fall prevention strategies for this vulnerable group.

This study looks at how bariatric surgery affects two key body chemicals—cortisol and bile acids—in obese women. Researchers will measure these substances before and after surgery in 30 non-menopausal women with a BMI between 35 and 50. The goal is to understand why the surgery l…

This study looks at 236 adults with severe heart failure who need a heart-lung machine (ECMO). It compares two ways of deciding when to give blood transfusions: one based on a standard hemoglobin level, and another based on how much oxygen is in the blood. The goal is to see whic…

This study looks at why some babies born with a gap in their food pipe (esophageal atresia) develop dumping syndrome, a condition causing dangerous blood sugar drops after meals. Researchers will monitor 15 infants with heart rate and glucose sensors and a stomach-emptying scan t…

This study follows 750 adults who are getting a standard procedure (catheter ablation) for atrial fibrillation, a common heart rhythm problem. The main goal is to figure out why the condition comes back in up to 45% of people within a year. Researchers will track participants for…

This study looks at whether brain wave tests (EEG) done before and after heart surgery in babies under 1 year old can help predict future learning, attention, or autism problems. About 50 babies with congenital heart disease will be followed. The goal is to find early signs of br…

This study follows 1000 people who had weight-loss (bariatric) surgery 5 years ago to see how well they maintain weight loss. Researchers want to learn why some succeed long-term while others do not, and which surgery type works best. The goal is to help future patients choose th…

This study tests whether an artificial intelligence (AI) tool can help doctors diagnose kidney diseases more accurately. About 100 doctors will review up to 10 online patient cases. Some doctors will see AI suggestions before making their final diagnosis, while others will not. R…

This study looks at whether special brain cells called tanycytes have trouble moving a key hormone (leptin) in people with Alzheimer's disease or frontotemporal dementia. Researchers will measure leptin levels in blood and spinal fluid from 102 participants. The goal is to unders…

This study looks at how to improve removal of blood clots in the brain after a hemorrhagic stroke. Researchers will create blood clots in the lab from people with and without bleeding risks, then test different doses of a clot-busting drug. The goal is to find the best dose for e…

This study is creating a large French database to collect information on people with esophageal or stomach cancer. Researchers will track what happens after surgery, including cancer return and survival rates. The goal is to better understand these cancers, not to test a new trea…

This study tests a brain imaging technique called fNIRS to see how children's brains respond to speech. It includes 40 infants and toddlers, some with normal hearing and some with hearing loss who use hearing aids. The goal is to find a better way to measure hearing aid effective…

This study looks at how swelling around a brain bleed affects recovery. Researchers will follow 500 adults who had a spontaneous hemorrhagic stroke to see if the swelling is linked to long-term disability. The goal is to better understand this swelling so future treatments can ta…

This study looks at how a woman's metabolism, physical activity, and sleep patterns influence whether her ovaries recover and her period returns after chemotherapy for breast cancer. Researchers will follow 50 women aged 25-35 who have lost their periods due to chemo. The goal is…

This study follows 300 teenagers born with esophageal atresia, a condition where the esophagus is not fully formed at birth. Researchers aim to track common long-term problems like acid reflux, eating difficulties, and breathing issues. By collecting blood and tissue samples, the…

This study follows 320 people who had omega gastric bypass surgery 8 to 12 years ago to compare long-term side effects of two different loop lengths. Researchers will track serious complications, nutritional problems, weight loss, and quality of life. The goal is to find out whic…

This study looks at how weight-loss surgery changes bone marrow fat and bone density in 40 postmenopausal women with obesity. Researchers will compare two surgery types and check for links to diabetes, hormones, and other factors. The goal is to better understand why bone loss ha…