University Hospital, Lille

This study follows one Parkinson's patient who has been receiving A-dopamine directly into the brain for years. The goal is to track safety and gradually reduce the dose to avoid sudden停药, switching to an alternative treatment if needed. It focuses on managing the transition rath…

This study looked at whether a high-fat diet changes how the body uses energy in children with mitochondrial cytopathy, a condition that affects energy production. Thirty-six children aged 5 to 21 were randomly assigned to eat either a normal or high-fat diet, then switched. Rese…

This study tested a procedure to transplant insulin-producing cells (islets) into 14 people with type 1 diabetes who had already received a kidney transplant. The goal was to help them stop taking insulin and keep their blood sugar under control. Participants continued taking imm…

This early-phase study tested a combination of five chemotherapy drugs, including clofarabine, in 20 children and young adults whose acute lymphoblastic leukemia had returned or did not respond to initial treatment. The main goal was to find the safest dose of clofarabine when us…

This study looked at whether the antifungal drug fluconazole could lower levels of certain antibodies (ASCA) and prevent Crohn's disease from returning after bowel surgery. 35 people with Crohn's who had recent surgery took either fluconazole or a placebo for 6 months. The goal w…

This study tested a combination of pomalidomide and dexamethasone in 63 patients with relapsed or refractory multiple myeloma who also have specific high-risk genetic changes (deletion 17p or translocation 4;14). The goal was to see how long the treatment could keep the disease f…

This study tested a combination of two drugs, pomalidomide and dexamethasone, in 84 people with advanced multiple myeloma whose cancer had stopped responding to two other standard treatments. The goal was to see if this new combination could shrink tumors or slow the disease. Par…

This study looked at 192 critically ill patients who were given antifungal drugs for a suspected fungal infection. Researchers wanted to see if using special fungal biomarkers could allow doctors to safely stop the drugs earlier than usual. The goal was to reduce unnecessary medi…

This study looked at whether gastric bypass surgery or the best available medical treatment is more effective for obese patients with poorly controlled type 2 diabetes. Researchers tracked 66 participants to compare death rates, weight loss, blood sugar control, quality of life, …

This study compared two surgical techniques to repair a cystocele (a type of bladder prolapse) in 262 women. The goal was to see which method—laparoscopic sacropexy or vaginal mesh surgery—causes fewer complications after one year. The results help doctors choose the safest appro…

This study tested whether extra nurse-led education and follow-up, including a caregiver, helps stroke patients with high blood pressure control better than usual care. About 290 patients over 60 who had a first stroke and high blood pressure took part. The main goal was to see i…

This study tested a new approach for people with advanced Parkinson's disease who have severe movement problems despite standard treatments. A pump placed in the brain delivered a special form of dopamine continuously, compared to taking many oral doses each day. The goal was to …

This study looked at how well a special knee replacement (MUTARS prosthesis) works after removing a bone tumor. Nine patients were checked to see if they could lock their knee and walk actively. The goal was to understand if this prosthesis helps restore normal walking after canc…

This study looked at 40 adults aged 18-25 who had a first-time shoulder dislocation. It compared early arthroscopic surgery to repair the torn tissue with standard immobilization in a sling. The goal was to see if surgery reduces the chance of the shoulder dislocating again withi…

This study tested whether a drug called deferiprone, which removes extra iron from the brain, could slow the progression of ALS (Lou Gehrig's disease). The trial included 372 adults with early-stage ALS. Researchers measured changes in physical function and survival over 12 month…

This study tested a combination of three drugs (carfilzomib, melphalan, and prednisone) in 32 elderly patients (65 years or older) with newly diagnosed multiple myeloma, a type of blood cancer. The goal was to find the safest dose of carfilzomib and see how well the combination w…

This study looked at whether people with severe alcoholic hepatitis who did not get better with medicine could safely receive a liver transplant sooner than the usual 6-month waiting period. Researchers compared alcohol relapse rates in 284 patients who got early transplants to t…

This study tested a combination of daratumumab and dexamethasone in 64 adults with multiple myeloma that had stopped responding to three previous treatments. The goal was to see how many patients achieved a partial response or better. The treatment aims to control the disease, no…

This study tested a drug called deferiprone in 23 people with ALS. The drug is designed to remove extra iron from the brain, which may help slow the loss of nerve cells. The goal was to see if the drug is safe and if it can slow the worsening of symptoms over time.

This study tested a stronger light dose during surgery for glioblastoma, a serious brain cancer. 14 patients received the light therapy along with standard treatment (surgery, chemo, and radiation). The goal was to find the highest safe light dose and see if it helps control the …

This early study tested whether a protein from a parasite (P28GST) is safe for people with moderate Crohn's disease. Ten adults with ileal or ileo-colic Crohn's received the treatment before or after bowel surgery. The goal was to see if it could control inflammation without caus…

This study tested whether a drug called EXACYL can reduce bleeding during and after jaw surgery. 157 patients having surgery to correct a receding jaw took part. The drug was given before surgery and compared to a placebo to see if it safely lowered blood loss.

This study tested whether a drug called deferiprone, which removes extra iron from the body, could slow down Parkinson's disease. 372 adults with early Parkinson's who were not yet on other treatments took either deferiprone or a placebo for 9 months. The goal was to see if the d…

This study tested whether a personalized electronic program could help pregnant women with obesity gain a healthy amount of weight and reduce the need for delivery procedures like C-sections or forceps. Over 800 women participated, using an online tool to track weight and get adv…

This study tested a 'joint crisis plan' (SOS plan) for people with schizophrenia or schizoaffective disorder. The plan is created together by the patient, their family, and their healthcare team to guide care during a mental health crisis. The goal was to see if having this plan …

This study tested if a type of acupuncture called moxibustion can safely turn a breech baby (feet-first) before birth. 328 pregnant women with a breech baby received either real or fake acupuncture. The goal was to see if the treatment could help the baby flip head-down, potentia…

This study compares two surgical methods—laparoscopic sacropexy and vaginal mesh surgery—for repairing a type of bladder prolapse called cystocele. Researchers followed 220 women for four years to see which approach provides better symptom relief and quality of life. The goal is …

This small pilot study tested whether adding a light-activated drug treatment during surgery is safe and feasible for people with glioblastoma, an aggressive brain cancer. Ten patients received the therapy alongside standard surgery and chemoradiation. The main goal was to see if…

This study tested a new treatment for malignant pleural mesothelioma, a rare and aggressive lung cancer. Six patients received a combination of surgery, light-activated drug therapy (PDT), chemotherapy, and radiation. The goal was to see if this intense treatment plan was safe an…

This study looked at whether using special tests (biomarkers) for fungal infections could help doctors safely stop antifungal medicines earlier in intensive care patients. The goal was to reduce the number of days patients receive these drugs, which can have side effects. The stu…

This study tested whether using a biological mesh (made from natural tissue) is better than standard wound care for people with an infected belly hernia. About 110 adults with an infected hernia took part. The main goal was to see if the mesh reduces infections and wound problems…

This study looked at whether adding an antibiotic (amoxicillin-clavulanic acid) to the usual steroid treatment could help people with severe alcoholic hepatitis live longer. About 297 adults at high risk of death within two months were given either steroids alone or steroids plus…

This study looked at whether giving people with alcohol dependence a longer course of diazepam (a month instead of the usual week) during detox could help them avoid relapsing into drinking. Twenty-six adults took part. The goal was to see if the extended treatment reduced the nu…

This study tested a freeze-dried plasma that can be mixed and used in just 6 minutes, without needing a blood type match. It included 42 trauma patients with severe bleeding. The goal was to see if this quick-to-use plasma helps control bleeding better than standard frozen plasma…

This study tested a personalized coaching program for children with type 1 diabetes who find it hard to adjust their insulin doses. Over 6 months, nurses provided phone calls and secure messages to help families manage blood sugar levels. The goal was to see if this remote suppor…

This study looked at the drug lenalidomide in 17 people with Waldenstrom macroglobulinemia, a rare blood cancer that had returned or stopped responding to other treatments. The main goal was to find a dose that is safe and tolerable. Researchers measured side effects and how many…

This study tested the drug vismodegib in 55 people with advanced basal cell carcinoma (a type of skin cancer) to see if taking it before surgery could make the tumor smaller and allow for a less extensive operation. Participants took the drug for a period before their planned sur…

This study tested whether a more detailed remote monitoring system could reduce deaths or hospital stays for heart failure patients who have a special heart device (CRT). Over 650 adults were followed for 27 months. The goal was to see if extra monitoring helps catch problems ear…

This study tested two doses of tranexamic acid, a drug that helps blood clot, to see if it could reduce blood loss in women having a C-section who were already bleeding heavily (over 800 mL). The trial involved 225 participants and compared the drug to a placebo. The goal was to …

This study tested a drug called nilotinib in 65 adults with chronic graft-versus-host disease (GVHD), a complication after a stem cell transplant where donor cells attack the patient's body. Participants had already tried imatinib without success. The goal was to see if nilotinib…

This pilot study tested whether giving a sodium lactate solution to people with septic shock could help manage their fluid balance. Septic shock is a life-threatening condition where blood pressure drops dangerously due to infection. The study involved 59 participants and compare…

This study looked at 30 adults with lung cancer that had spread to the brain. Researchers compared two types of MRI scans (T1 and T2*) to see which one works better for finding and tracking brain tumors during standard treatment. The goal is to improve diagnosis and monitoring wi…

This study looked at 68 intensive care patients who were breathing on their own. Doctors measured changes in a vein pressure reading during a deep breath to see if it could predict who would benefit from extra fluids. The goal was to find a simple, non-invasive way to guide fluid…

This study tested whether a hand-held device (dynamometer) can accurately measure the strength of a key foot muscle in healthy adults. The goal is to provide doctors with a simple, reliable tool to assess flat foot deformity. 46 participants had their muscle strength measured wit…

This study tested a new approach to diagnose peroxisomal diseases, a group of rare genetic disorders. The strategy combines advanced metabolic and genetic testing in patients with suspected symptoms. Researchers aimed to reduce the time and confusion often involved in getting a c…

This study tested a new blood test called LLIFT to see if it can accurately diagnose fatty liver and NASH without needing a liver biopsy. Researchers studied 158 people at high risk due to obesity, diabetes, or high blood pressure. The goal is to find a simple, non-invasive way t…

This study tested whether a non-contact sensor system called KASPARD can help prevent falls in nursing home residents. Researchers compared the number of falls during 100 nights with the system on versus 100 nights with it off. The study included 40 residents aged 65 and older wh…

This study tested whether giving an antibiotic (clindamycin) to pregnant women with bacterial vaginosis (a common vaginal infection) before 13 weeks could reduce the chance of late miscarriage or very early preterm birth. Over 3,100 pregnant women took part. The goal was to see i…

This study tested whether a specially shaped tracheal tube cuff could better seal the airway in critically ill patients on breathing machines. Researchers wanted to see if this tapered shape reduced the leakage of stomach and mouth fluids into the lungs, a problem that can lead t…

This study tested whether methylphenidate (Ritalin), a drug used for ADHD, can improve walking problems and attention in people with advanced Parkinson's disease. 69 participants with severe gait freezing took either the drug or a placebo for 3 months. Researchers measured steps,…

This study tested whether Ericksonian hypnosis can reduce chronic pain in people with Parkinson's disease. 33 adults were split into two groups: one received hypnosis sessions for 2 months, the other got usual care. Researchers measured pain intensity and other pain-related score…

This study compared two surgical methods for esophageal cancer: open surgery and laparoscopically-assisted (keyhole) surgery. The goal was to see if the keyhole approach reduces serious complications within 30 days after the operation. 207 patients with esophageal cancer took par…

This study tested whether teaching people with chronic low back pain about the biology of pain (instead of just spinal anatomy) could reduce their disability. 88 adults with long-term back pain took part. The goal was to see if this approach, combined with rehab, works better tha…

This study tested a fast-recovery program for people having minimally invasive kidney surgery (laparoscopic or robotic) to remove kidney tumors. The goal was to see if the program could safely shorten hospital stays by at least one day without increasing complications. Sixty adul…

This study tested a non-invasive brain stimulation technique called rTMS in 85 people with schizophrenia who still had severe hallucinations despite medication. Using MRI scans to precisely target the brain areas involved, the treatment aimed to reduce the strength and frequency …

This study tested two different pain relief methods after liver surgery: continuous wound infiltration with local anesthetics and spinal analgesia. The goal was to see which method reduces the need for morphine and lowers the chance of long-term pain. A total of 186 adults having…

This study tested whether a personalized exercise program could improve daily function and quality of life for people with polymyositis or dermatomyositis, two rare diseases that cause muscle inflammation and weakness. Eighty adults with stable muscle problems took part. Research…

This study tested two stress management programs for people diagnosed with adjustment disorder with anxiety. One program was online, the other was in-person, and both were compared to no treatment. 120 adults completed the 5-week program, and researchers measured changes in anxie…

This study looked at whether medical hypnosis can help reduce anxiety and pain during electroneuromyography (ENMG), a nerve test that can be uncomfortable. Six anxious adults were enrolled to compare hypnosis with standard care. The goal was to see if hypnosis could make the proc…

This study tested whether wearing a special pressure sleeve for 6 months could improve hand function in children with cerebral palsy. About 100 children aged 5 to 10 took part. The sleeve is made of stretchy material and applies gentle pressure to the arm. Researchers measured ha…

This study tested whether sildenafil (the drug in Viagra) can speed up healing of painful finger ulcers in people with scleroderma. 84 participants received either sildenafil or a placebo for 90 days. The main goal was to see how long it took for the ulcers to heal.

This study tested whether special body wraps (wet or dry) can help reduce severe injurious behaviors in 48 children with autism. The goal was to see if this gentle, drug-free approach could calm aggressive or self-harming actions. It was an early-stage trial comparing wet versus …

This study tested a new device called 'Hypnos-Pro' — a mask with lights, headphones, and a touchpad — to help men relax during painful prostate biopsies. 88 participants used the mask along with standard local anesthesia. The goal was to see if the mask could lower pain and anxie…

This study looked at whether a pulmonary rehabilitation program could improve daily activity in 38 people with Stage IV pulmonary sarcoidosis, a severe form of lung scarring. Participants followed a rehab program, and their activity levels, breathing, and quality of life were mea…

This study tested a special monitor that tracks the body's pain balance during general anesthesia for laparoscopic surgery. The goal was to see if using this monitor to adjust pain medicine could reduce side effects like low blood pressure or slow heart rate. 37 adults having gal…

This study looked at whether medical hypnosis can lower stress and make the hospital experience better for people with chronic diseases. Twenty-four adults staying in an internal medicine unit took part. One group received a hypnosis technique called "the place of safety," while …

This study tested whether a clonidine nasal spray can reduce anxiety in children aged 1 to 5 before minor surgery. Researchers compared the spray to a placebo in 90 kids. The goal was to see if children were calmer and more cooperative when going under anesthesia.

This study tested whether adding ketamine to a standard antidepressant (milnacipran) helps reduce depression in people with severe, progressive diseases who are in palliative care. Half of the 42 participants received ketamine plus milnacipran, and the other half received a place…

This study looked at whether aesthetic therapy (like skincare and relaxation) can reduce anxiety and improve quality of life for patients with acute leukemia or those who had a stem cell transplant. These patients are isolated in a special hospital area for at least 28 days. The …

This study looked at whether a tailored physical activity program could help children and teens with inflammatory bowel disease (IBD) improve their bone density. Kids with IBD often have weaker bones due to inflammation, medication, and low activity levels. Fifteen participants c…

This study tested a program that teaches people with early-stage Parkinson's disease how to add more physical activity into their daily lives. 89 participants either received the program or were put on a waiting list. The goal was to see if the program increased their moderate-to…

This study tested a new device called Flexitheralight against the usual light therapy for actinic keratosis, which are rough spots caused by sun damage. About 29 adults with at least 10 spots on their forehead or scalp took part. The goal was to see if the new device works just a…

This study tested whether a low dose of methylphenidate (a drug used for ADHD) combined with computer-based cognitive training could improve thinking skills in healthy older adults. Thirty-one volunteers without memory problems took part in the 6-week program. The goal was to see…

This study looked at whether two sessions of hypnosis could lower anxiety in pregnant women experiencing preterm premature rupture of membranes (PPROM). 60 women took part, with some receiving hypnosis and others standard care. The goal was to see if hypnosis helps ease anxiety a…

This study tested whether injecting a numbing medicine (ropivacaine) into the nose during sinus surgery can reduce pain afterward. 184 adults having endoscopic sinus surgery took part. The goal was to see if this simple step could improve recovery and lower the need for other pai…

This small pilot study looked at whether taking metformin 30 or 60 minutes before a meal changes how the body absorbs carbohydrates. Researchers tested this in one person with obesity and high blood sugar. They measured sugar absorption and checked for stomach side effects. The g…

This study tested a non-invasive device called ANI that measures heart rate patterns to assess comfort in 20 non-communicating patients receiving end-of-life palliative care. The goal was to see if the ANI could reliably detect pain or stress during routine care, compared to a st…

This study looks at whether a new pain management protocol can reduce pain for people undergoing in vitro fertilization (IVF). Researchers compared pain scores from 206 patients who received the new protocol to data from an earlier study. The goal is to see if the new approach he…

This study looked at 67 people with nerve damage to see if walking and balance tests can help tell the difference between inherited and acquired forms. Participants did simple tasks like standing on a pressure mat and a timed walk test. The goal was to find clear markers that doc…

This study looked at how heart devices and treatments affect a blood protein called von Willebrand factor, which helps blood clot. Researchers studied 500 adults with advanced heart failure or aortic stenosis to understand when and why bleeding problems happen. The goal was to le…

This study looked at how inflammatory bowel disease (IBD) impacts oral health and daily life. Researchers compared 138 adults with IBD to people without IBD, using a questionnaire to measure oral health-related quality of life. The goal was to identify factors like medications or…

This study looked at whether removing a breathing tube with extra air pressure (positive pressure) can prevent oxygen levels from dropping after abdominal surgery. 264 adults having planned abdominal surgery took part. The goal was to see if this technique reduces breathing compl…

This study looked at 90 sepsis patients with low blood pressure to see if changes in blood vessel size during breathing could predict who needs extra fluids. Doctors often give fluids to improve circulation, but too much can be harmful. The goal was to find a simple, non-invasive…

This study tested whether a non-invasive device called ccNexfin can accurately measure heart function (cardiac output) in pregnant women. About 100 women past 32 weeks of pregnancy participated. The goal was to see if this device could replace or supplement standard ultrasound mo…

This study looked at whether having attention deficit hyperactivity disorder (ADHD) makes it harder for people to stay sober after completing a detox program for alcohol dependence. Researchers followed 113 adults for 12 weeks after detox, using both a simple screening questionna…

This study looked at 500 people with ALS (a nerve disease that weakens muscles) to find signs—called biomarkers—that could predict how fast the disease will progress and how long patients might live. Researchers collected medical images, blood samples, and electrical tests of ner…

This study looked at how the rheumatoid arthritis drug tofacitinib changes body composition—like fat, muscle, and bone density—in 10 patients. Researchers measured changes in belly fat and bone marrow fat over time. The goal was to gather early data, not to test if the drug works…

This study aimed to see if environmental exposures stored in teeth differ between people living in areas with high versus low rates of Crohn's disease. Researchers compared teeth from 14 adults in northern France. The goal was to identify possible environmental triggers for Crohn…

This study looked at how breast cancer treatments affect sexual health in women. Researchers followed 25 women who had non-metastatic breast cancer and were referred for fertility preservation. Participants filled out anonymous questionnaires about their sexual function, quality …

This study looked at whether a quick test called Unyvero can help doctors pick the right antibiotics sooner for patients with pneumonia who are on breathing machines. The standard method takes days, which can lead to using broad-spectrum antibiotics that may not be ideal. Researc…

This study aimed to find out which factors predict death within 28 days for adults hospitalized with COVID-19 at Lille University Hospital. Researchers collected medical, lab, and imaging data from 757 patients to identify these predictors. The goal was to better understand the d…

This study looked at 41 people with early-stage vocal cord cancer to see which treatment—surgery or radiation—leads to better voice quality after 5 years. Participants completed a questionnaire about how their voice affects daily life. The goal is to help doctors and patients cho…

This study looked at 158 people with Parkinson's disease to see if different thinking (cognitive) patterns are linked to specific brain changes. Researchers used brain scans to measure gray matter density and identify distinct cognitive profiles. The goal was to better understand…

This study looked at 550 stroke patients to understand why some people recover better than others. Researchers checked blood markers, brain scans, and other health information to find links between these factors and recovery. The goal was to learn more about how the body protects…

This study tested an electronic device that automatically controls the pressure in the cuff of a breathing tube in critically ill patients. The goal was to see if it keeps the pressure in a safe range better than manual checks. 18 ICU patients on ventilators were monitored for 24…

This study looked at whether a substance called tissue factor (TF) in the blood can help predict how serious colorectal cancer is and if it might come back. Researchers measured TF levels in 26 adults before and after surgery to remove their tumors. The goal was to see if higher …

This study tested a new questionnaire called Serenat to see if it accurately measures well-being at work. Researchers asked 226 adults who were working and had adjustment disorder to fill out the survey. The goal was to validate the scale so it can be used in the future to assess…

This study looked at how skin changes from systemic sclerosis (scleroderma) affect a person's appearance and emotional well-being. Researchers compared 170 patients to healthy people using surveys about body image and distress. The goal was to understand the burden of these visib…

This study looked at why overweight or obese pregnant women choose to take part in a 12-week program that includes nutrition advice and weekly exercise sessions. Researchers tracked 195 women to see which factors—like age, health history, or motivation—influenced their participat…

This study looked at 163 adults with chronic spontaneous urticaria (long-term hives) to see how many needed a higher dose or more frequent injections of the drug Xolair (omalizumab) after 3 months. Researchers simply observed what doctors prescribed in real life, without giving a…

This study used MRI scans to look at how hamstring tendon grafts used to repair the anterior cruciate ligament (ACL) heal and change shape over time. Researchers followed 24 adults who had ACL reconstruction surgery at least one year earlier. The goal was to understand how often …

This study looked at genetic changes in prostate cancer tissue from 84 men who had their prostate removed. The goal was to find DNA markers that could predict if the cancer would come back or spread. By identifying these markers, doctors may one day better tailor follow-up care a…

This study looked at 58 pregnant women with and without PCOS to understand how the hormone AMH might be passed from mother to child and increase the baby's risk of developing PCOS later in life. Researchers measured AMH, leptin, and other hormone levels during pregnancy. The goal…

This study tested whether a device called NIPE can measure pain and discomfort in very premature babies (born before 34 weeks) who are sedated and on breathing machines. Researchers watched 50 infants and compared NIPE readings before, during, and after care. The goal was to see …

This study aimed to create a computer algorithm that can detect epileptic seizures by continuously analyzing the heart's electrical activity (ECG). Researchers studied 40 epilepsy patients who had seizures recorded during long-term monitoring. The goal was to see how accurately t…

This study looked at how shortness of breath changes over 6 months in 51 people with idiopathic pulmonary fibrosis (IPF), a lung scarring disease. Researchers measured both the physical sensation and emotional impact of breathlessness using questionnaires. The goal was to better …

This study looked at how muscles use oxygen during exercise in people with different neuromuscular diseases compared to healthy volunteers. Seventeen participants did a knee exercise while a device measured muscle oxygen levels. The goal was to understand if oxygen use is impaire…

This study examined blood cells called eosinophils in 70 people with asthma, chronic sinusitis, or both, compared to healthy volunteers. The goal was to identify different cell patterns that could help doctors choose the best targeted therapy for each patient. No new treatment wa…

This study looked at 30 people having brain surgery to see if tilting their body up or down changes a device that measures pain (called ANI) while they are asleep. The goal was to understand if the device is still accurate when blood flow shifts. Results will help doctors better …

This study looked at whether a heart-rate-based index (called ANI) can help measure pain in 17 children with cerebral palsy. The children were monitored during painful procedures like injections and physical therapy. The goal was to see if this method could be a reliable way to a…

This study tested whether a rapid test called Unyvero could help doctors decide sooner whether to stop or change antibiotics in patients on breathing machines with suspected aspiration pneumonia. About 266 adults with risk factors like swallowing problems or altered consciousness…

This study looked at how many fishermen and fish-factory workers have fish allergy compared to other workers in Boulogne-sur-Mer, France. The goal was to see if working with fish increases the chance of developing an allergy. Researchers checked 486 people for signs of fish aller…

This study tested a computer system that alerts pharmacists about potential drug risks for older patients in the hospital. The goal was to reduce serious side effects like acute kidney failure and high potassium levels. Researchers enrolled 783 older adults and used specific rule…

This study looked at how having inflammatory bowel disease (Crohn's or ulcerative colitis) as a child affects work and education in adulthood. Researchers surveyed 343 adults who were diagnosed before age 17 to compare their employment and schooling with the general population. T…

This study aimed to find simple blood markers that could predict if a person with suspected COVID-19 in the emergency room would later get sicker. Researchers followed 373 patients to see if routine lab tests could forecast worsening. The goal was to help hospitals better allocat…

This study observed 257 emergency patients on ECMO (a heart-lung machine) to understand why many experience serious bleeding. Researchers checked if a defect in von Willebrand factor, a protein that helps blood clot, was related to these bleeds. The goal was to learn more about t…

This study looked at over 3,500 older adults (75+) after a hospital stay in an acute geriatric unit. Researchers used special statistical models to better predict the chances of death, being readmitted to the hospital, or moving to a nursing home. The goal is to help doctors and …

This study looked at physical fitness in 100 children and teens (ages 10-17) with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis, or unclassified colitis) and compared them to healthy kids of the same age, weight, and sex. Researchers measured cardiorespi…

This study looked at whether a special 3D X-ray taken right after fixing a belly aneurysm can replace the usual CT scan done before leaving the hospital. 427 patients were randomly assigned to get either the standard 2D X-ray plus CT scan, or just the new 3D X-ray. The goal was t…

This study looked at a program called VigilanS, which provides follow-up care for people in northern France who survived a suicide attempt. The program coordinates doctors and mental health professionals to offer support and quick help during a crisis. Researchers tracked nearly …

This study followed 72 young adults who were part of a larger teen health study 10 years earlier. Researchers looked at their current heart disease risk using a special score and compared it to their teenage diet and lifestyle. The goal was to find new risk factors and identify g…

This study aimed to find new biological markers (biomarkers) that can help doctors diagnose hypereosinophilic syndrome (HES) more easily and accurately. Researchers used a technique called proteomics to analyze samples from 41 participants. The goal was to improve diagnosis by di…

This study tested a program to help cancer patients improve their emotional skills after finishing treatment. 26 people with stomach or lung cancer took part. They either learned emotional skills like identifying and managing emotions, or did relaxation exercises. The goal was to…

This study looked at whether a type of white blood cell called eosinophils plays a role in the scarring (fibrosis) seen in systemic sclerosis, an autoimmune disease. Researchers compared blood and tissue samples from 40 patients with systemic sclerosis and 30 healthy volunteers. …

This study looked at whether a special heart monitor (called ANI) can predict how a patient will react when a breathing tube is placed. Researchers gave a small electrical pulse to mimic pain and then checked if the heart's response matched the patient's movement or blood pressur…

This study looked at how strong and long-lasting the immune response to the Pfizer COVID-19 vaccine is in elderly people living in nursing homes. Researchers compared their immune cell and antibody levels to those of younger adults aged 40-65. The goal was to understand if the va…

This study checked how often emphysema (a lung condition) happens in people with a FLNA gene mutation. Eight participants had a chest exam, breathing tests, and a CT scan. The goal was to confirm if the gene change is linked to unexplained emphysema.

This study tested a short 10-question screening tool called DEPITAC to help nurses identify post-traumatic stress disorder (PTSD) in people hospitalized after a road traffic accident. About 274 participants were enrolled within two weeks of their accident. The goal was to see if …

This study measured thinking abilities in 140 people hospitalized for suicidal thoughts or a recent suicide attempt. Researchers used a quick test called MoCA to see if low scores are common during a crisis. The goal is to better understand the role of cognitive problems in suici…

This study looked at the gut bacteria of 214 people with Crohn's disease, comparing those diagnosed as children (under 17) with those diagnosed after age 40. The goal was to see if the bacteria and genetic factors differ by age, which could mean Crohn's is actually different dise…

This study looked at nearly 700 men and women entering prisons in northern France to find out how common mental health and substance use problems are among them. Researchers compared these rates to the general population to understand the differences. The goal was to gather infor…

This study examined whether being infected with SARS-CoV-2 (the virus that causes COVID-19) increases the chance of intensive care unit (ICU) patients acquiring multidrug-resistant bacteria. Researchers tracked 368 critically ill adults to see how many developed these hard-to-tre…

This study looked at how older adults with and without Alzheimer's disease move in time to music. Researchers wanted to understand if this ability to synchronize movements with a beat is linked to emotional state and nonverbal communication. The study involved 240 participants an…

This study tested whether a miniaturized ultrasound probe placed in the esophagus could help predict outcomes in 50 patients with severe lung failure (ARDS). The researchers measured how much the main vein collapses during breathing, which may indicate heart strain. The goal was …

This study tested whether a digital platform could help people recover physically and emotionally after surgery for throat or esophageal cancer. Thirty patients used the platform after their operation, and researchers measured how many people agreed to join and how often they use…

This study looked at 46 people who had a first episode of optic neuritis, an inflammation of the eye nerve. Researchers used MRI scans to measure the length of the nerve lesion and checked if it could predict how much nerve tissue would be lost in the retina one year later. The g…

This study looked at whether drinking caffeine is linked to how Huntington's disease progresses in people who have the gene but do not yet show symptoms. Researchers followed 77 adults for several years, measuring brain changes and thinking skills. The goal was to learn if caffei…

This study looked at the stressful life events teens experienced in the year before a suicide attempt. Researchers compared 39 teens who had attempted suicide with teens who had never had suicidal thoughts. They wanted to see if there was a pattern of increasing hardship that cou…

This study looked at 50 ICU patients with acute respiratory failure to see if a heart ultrasound test (measuring how the main vein collapses when breathing in) could predict who would die or need a breathing machine. The goal was to understand if checking fluid responsiveness hel…

This study looked at whether a test using 6 different markers from tumor samples could predict if advanced lung cancer patients would live longer or have their cancer worsen after treatment with immunotherapy plus chemotherapy. Researchers studied 106 patients and compared the te…

This study looked at whether telling children and teens that they are wearing an activity tracker (accelerometer) changes how much they move. Eighty healthy volunteers aged 10 to 18 wore the device for four days. Half were told it measured activity, the other half were told it me…

This study tested a decision-making tool to help doctors tell which children with fever and low white blood cells after chemotherapy have a serious infection. Researchers looked at 1,900 children aged 1 to 18 with cancer or blood disorders. The goal was to see if the tool could a…

This study looked at whether doctors can safely reduce or stop antifungal drugs early in immunocompromised ICU patients suspected of having a fungal infection. Researchers tracked 275 patients across 14 ICUs to see how often treatment was scaled back and if it was safe. The goal …

This study looked at 700 people with Parkinson's disease to find clues that predict whether deep brain stimulation will improve their quality of life. Researchers tracked patients for up to 5 years after the procedure. The goal is to help doctors choose the right patients for thi…

This study looked at whether using a Foley catheter (a small balloon placed in the cervix) at home could help start labor in first-time mothers whose pregnancy has gone past the due date. 43 women took part. The goal was to see if this approach is safe and effective compared to w…

This study looked at how often joint pain happens in people with lung, ovarian, or colorectal cancer who are taking the drug bevacizumab. Researchers surveyed 71 patients over 6 months to track any joint pain and its severity. The goal was to better understand this side effect, n…

This study reviewed medical records of nearly 3,000 patients who had surgery for esophageal cancer between 2000 and 2010. The goal was to identify factors that predict whether the cancer will come back and how long patients survive. Researchers also looked at the impact of treatm…

This study examined how the COVID-19 pandemic and related public health measures impacted asthma control in 577 children aged 3 to 16 in France. Researchers compared asthma control and flare-ups during the pandemic to data from before the pandemic. The goal was to understand if l…

This study followed 134 people who had a first episode of neurological symptoms (clinically isolated syndrome) that could lead to multiple sclerosis. The goal was to develop better ways to detect and monitor nerve damage early using MRI and eye exams. By identifying those at high…

This study looked at 48 adults on a heart-lung machine (ECMO) for severe heart failure. Researchers compared oxygen levels measured from different places in the body to see if they match. The goal was to improve how doctors monitor these patients.

This study followed 229 adults over age 40 who had a stroke to learn what factors might lead to dementia or memory problems later. Researchers looked at medical history, brain scans, and daily living skills. The goal was to identify risks and protective factors, not to test a tre…

This study set up a national registry in France to track babies born with esophageal atresia, a birth defect where the esophagus is not fully connected. Researchers collected data on about 1,460 newborns to understand how common the condition is, what other health issues may occu…

This study looked at 451 children with asthma in northern France to see if mold in their homes made their asthma harder to control. Researchers asked families about mold and checked asthma symptoms during doctor visits. The goal was to understand the link between mold exposure an…

This study followed 180 people with anorexia for 4 years to track changes in bone density and understand how fat-related hormones (like leptin and adiponectin) affect bone loss. Researchers measured bone density and blood markers every two years. The goal was to learn more about …

This study looked at 78 family caregivers of older adults (70+) with cancer to understand how social and economic factors affect their needs and stress. Researchers measured caregiver burden and other psychosocial factors to see if a personalized support plan could help. The goal…

This study looked at whether women with PCOS have different brain activity in the hypothalamus compared to healthy women. Researchers used special MRI scans to measure tiny changes in brain structure and chemistry. 52 women aged 19-30 took part, and the goal was to better underst…

This study looked at how often children with peanut or tree nut allergies have accidental allergic reactions in real life. Researchers followed 147 children in France to count these episodes and describe what caused them. The goal was to fill a gap in knowledge about reaction rat…

This study looked at whether getting an islet transplant after a kidney transplant helps people with type 1 diabetes keep their kidney working longer. Researchers reviewed records of 327 kidney transplant recipients in France from 2000 to 2017. They compared those who also receiv…

This study looked at whether adding a combined EEG-fMRI scan to standard tests helps doctors find the exact brain area causing seizures in people with hard-to-treat focal epilepsy. About 102 patients aged 8 and older who were being considered for surgery took part. The goal was t…

This study examined the genetic mutations and disease features in 29 French patients with APECED syndrome, a rare autoimmune condition. Researchers aimed to identify common gene changes and link them to symptoms. The goal was to improve understanding of the disease, not to test a…

This study looked at whether certain immune cells (B lymphocytes) contribute to scarring in people with systemic sclerosis, a disease that causes skin and organ hardening. Researchers compared blood and skin samples from 71 participants—patients and healthy volunteers—to measure …

This study explored whether a certain type of immune cell, called 4BL, is involved in multiple sclerosis (MS). Researchers compared blood samples from 125 people, including those with newly diagnosed MS, people with other neurological diseases, and healthy volunteers. The goal wa…

This study reviewed 37 patients who had surgery for webbed fingers (congenital syndactyly) using a specific technique called the Gilbert dorsal commissural flap. Researchers checked how well the web space held up over time and how the scars looked. The goal was to see if this new…

This study looked at how the body processes cortisol in 25 people with a rare genetic condition called familial partial lipodystrophy type 2 (FPL2), which causes abnormal fat distribution and severe metabolic issues. Researchers measured cortisol-related substances in urine and f…

This study looked at 800 people with hip or knee osteoarthritis to see if different patient questionnaires can be linked together. The goal was to help doctors compare results across studies and find out what score change actually matters to patients. No new treatment was tested;…

This study screened 233 children aged 6 to 66 months with congenital heart disease for neurodevelopmental disorders like delays in communication, movement, and problem-solving. Researchers used a parent questionnaire to identify children at risk. The goal is to understand how com…

This study compared how often patients on breathing machines developed lung infections. Researchers looked at three groups: people with COVID-19, people with the flu, and people with no viral pneumonia. The goal was to see if COVID-19 increases the chance of getting a ventilator-…

This study looked at how common sleep apnea is in obese pregnant women and whether using a CPAP machine can improve health for both mother and baby. Researchers followed 89 women with a BMI over 35 who were past 24 weeks of pregnancy. The goal was to see if treating sleep apnea r…

This study looked at 263 adults on breathing machines who showed signs of pneumonia. Researchers wanted to find out how many actually had a serious lung fungus called invasive pulmonary aspergillosis. They used blood and lung fluid tests to check for the fungus and tracked patien…

This study looked at blood cells from people with Parkinson's disease, ALS, and healthy volunteers to understand how a drug called deferiprone affects cell stress and energy use. Researchers collected samples from 90 participants and tested the drug in the lab. The goal was to le…

This study looked at 172 patients in the intensive care unit after surgery who needed insulin. Researchers compared two different ways of giving insulin through a vein to see which method caused fewer ups and downs in blood sugar levels. The goal was to find out if a special setu…

This study looked at frozen ovarian tissue from 9 young women with acute myeloid leukemia (AML) to see if any leukemia cells remained after they reached remission. The goal was to understand the risk of re-introducing cancer if the tissue is later used for fertility. No treatment…

This study followed 83 people with Parkinson's disease and related conditions, along with healthy volunteers, to see if walking patterns measured at home with special insoles can track disease progression. Participants wore the insoles for 10 days at a time, and their walking spe…

This study looked at how the pain medicine sufentanil travels from the amniotic fluid to the fetus and mother. Eight pregnant women who had decided to end their pregnancy due to a fetal problem took part. The goal was to learn more about giving pain relief directly to the fetus, …

This study followed 56 people with systemic sclerosis (scleroderma) who also have a serious lung condition called diffuse infiltrating pneumonia. Researchers measured lung function at 12 and 24 months to see how it changed and to identify factors that might predict worsening. The…

This study looked at 113 adults with myotonic dystrophy (Steinert's disease) to find out what factors are linked to low breathing (hypoventilation). Researchers measured lung function, sleepiness, fatigue, and thinking skills over 5 years. The goal was to better understand the di…

This study followed 29 people with Parkinson's disease to observe speech and movement issues that don't respond to standard medication. Participants underwent brain scans, breathing tests, and thinking assessments. The goal was to better understand these non-dopaminergic symptoms…

This study looked at how breathing pure oxygen under high pressure (hyperbaric oxygen therapy) affects the smallest blood vessels in the body. Fifteen healthy volunteers were exposed to different oxygen levels and pressures while researchers measured blood flow using special came…

This study tested whether using an ultrasound during surgery helps doctors decide the best way to remove endometriosis from the rectum. Ten women with deep pelvic endometriosis took part. Doctors performed an ultrasound before and after shaving off the endometriosis tissue to see…

This study looked at 42 infants who had surgery for a birth defect called esophageal atresia (types III and IV). The goal was to find out how many develop dumping syndrome, a condition where blood sugar drops after eating, by the time they are 3.5 months old. Babies took a glucos…

This study looked at 30 women with PCOS who had trouble ovulating. Researchers gave them a low dose of FSH and measured a hormone called AMH to see if it dropped when an egg follicle grew. The goal was to better understand why ovulation gets stuck in PCOS. No treatment was tested…

This study looked at whether giving women a self-test kit for HPV (the virus that causes cervical cancer) during a regular doctor visit would encourage more women to get screened. It involved 308 women aged 30-65 who were overdue for screening. Some women were offered the usual P…

This study looked at whether a bedside lung ultrasound can help predict breathing complications after surgery to remove esophageal cancer. 274 adults who had this surgery received ultrasound exams right after and one day after surgery. The goal was to see if ultrasound could catc…

This study looked at 45 postmenopausal women with knee osteoarthritis who needed knee replacement surgery. Researchers compared fat from bone marrow with fat from under the skin to see which one releases more harmful substances that damage joints. The goal is to find new ways to …

This study looked at whether a special liver scan (hepatobiliary scintigraphy) can predict the risk of liver failure after major liver surgery. 326 adults without cirrhosis who needed large liver resections were included. The goal was to see if the scan's measurement of liver fun…

This study looked at 174 adults with severe asthma who were starting a new biologic treatment (biotherapy). The goal was to see if their ability to work and be productive at their jobs improved after 6 months of treatment. Researchers measured presenteeism, which means being at w…

This study looked at 84 children and teens with inflammatory bowel disease (IBD) to see if being physically active helps their bone health. Researchers measured bone density and body fat using a special scan. The goal was to understand if regular moderate-to-vigorous activity can…

This study looked at how people with PTSD pay attention to their surroundings. Researchers measured how quickly 80 participants noticed changes in pictures, both neutral and emotional. The goal was to understand if PTSD makes people more sensitive to sudden visual changes, especi…

This study looked at how many people are needed to find as many user mistakes as possible when using the Zeneo® medical device. 60 healthy volunteers, some with knowledge of auto-injectors and some without, took part. The goal was to improve device safety by understanding how the…

This study tested a personalized follow-up plan (called ALGOS) for people who survived a suicide attempt. The goal was to see if this approach could reduce the number of repeat suicide attempts compared to standard care. Over 1,000 adults who left the emergency room after a suici…

This study looked at tissue samples from 6 babies born with esophageal atresia, a condition where the esophagus doesn't form properly. Researchers compared samples taken shortly after birth with those stored for longer periods to see if storage time affects the results. The goal …

This study looked at whether having heart surgery in the morning or afternoon changes how the heart muscle handles stress. Researchers took small tissue samples from 88 patients during planned heart surgery and tested them in the lab. The goal was to learn more about how the body…

This study tested a device that automatically gives a pain medicine (remifentanil) during surgery based on the patient's heart rate, blood pressure, and a pain index. 52 adults having burn surgery took part. The goal was to see if the device could lower the total amount of pain m…

This study tested whether a non-invasive monitor, already used in adults, can also measure pain signals in children under general anesthesia. Thirty children aged 5-12 received brief, mild electrical stimulations of varying strength before surgery. The goal was to see if the moni…

This study followed 73 people with autoimmune diseases like rheumatoid arthritis or multiple sclerosis who were starting treatment with rituximab. The goal was to track how many developed serious infections and identify what made some patients more at risk. Researchers also looke…

This study looked at 64 people with relapsing-remitting multiple sclerosis to understand how nerve damage in the eyes happens even when there is no active inflammation. By tracking changes in the retina over time, researchers hope to uncover the hidden processes that lead to visi…

This study tested two existing scores (PAWS and PEWS) to see how well they measure illness severity in children admitted to intermediate care units. Over 3,000 children took part, and researchers tracked vital signs like heart rate, breathing, and oxygen levels. The goal was to v…

This study tested whether adding a simple AI-written summary to brain MRI reports helps people better understand the results. Over 2700 adults read fictional MRI reports for headaches and answered questions about what they found. The goal was to see if the AI summary improved und…

This study looked at how fat cells in bone marrow might contribute to bone loss in osteoporosis. Researchers took bone samples from 20 adults during hip replacement surgery and grew bone-forming cells in the lab. They then exposed these cells to substances released by fat cells t…

This study followed 250 children under 4 with suspected congenital glaucoma to see if earlier diagnosis leads to better vision at age 4. Researchers measured eye pressure and visual sharpness to understand the link. The goal is to create awareness programs for doctors and teacher…

This study looked at whether doing extra leg strengthening exercises before ACL surgery helps patients recover better and return to sports. Six people with recent ACL tears took part. Researchers measured their leg muscle strength before and after a special exercise program to se…

This completed study looked at how different patterns of body fat—too much, too little, or unevenly distributed—affect insulin resistance and the immune system. Researchers measured various immune markers, especially interleukin-7, in 126 adults with obesity, lipodystrophy, or ty…

This study looked at how thoracic outlet syndrome—a condition that can cause nerve, artery, or vein problems in the neck and shoulder area—affects people's ability to work. Researchers surveyed 101 employed or formerly employed adults who had a confirmed artery blockage during ar…

This study looked at how people with post-traumatic stress disorder (PTSD) predict their emotional reactions to future events. Researchers compared 97 adults with and without PTSD to see if those with PTSD tend to expect more intense negative emotions than they actually experienc…

This study looked for hidden immune system problems in adults who get frequent or severe bacterial infections. Researchers screened 120 adults aged 18-65 who had repeated respiratory infections or at least one serious infection requiring hospital care. The goal was to see how oft…

This study followed 38 children who survived acute respiratory distress syndrome (ARDS) to see how their lungs were doing one year later. Researchers measured lung stiffness, breathing symptoms like cough and wheeze, and looked at CT scans for any lasting damage. The goal was to …

This pilot study looked at whether the COVID-19 virus can spread through the air during abdominal surgery on infected patients. Only 2 people took part. Researchers measured virus particles near the surgical site and around the room to understand risks to healthcare workers. The …

This study looked at how back muscles use oxygen during exercise in people with chronic low back pain compared to healthy volunteers. Researchers measured muscle oxygen levels and breathing to see if pain changes muscle metabolism. The goal was to better understand why back pain …

This study looked at how type 1 diabetes and long-term blood sugar control (HbA1c) affect the body's ability to deliver and use oxygen during exercise. Researchers compared 79 participants—some with type 1 diabetes and some healthy—to understand why people with diabetes often hav…

This study aimed to identify genes and environmental factors that increase the risk of developing Parkinson's disease. Researchers compared DNA and lifestyle data from over 2,200 people, including those with Parkinson's, related brain diseases, and healthy volunteers. The goal wa…

This study looked at whether measuring the size of a large vein (the inferior vena cava) through the liver can predict if a patient needs more fluids. It involved 40 adults in the ICU after heart surgery. The goal was to find a safe, non-invasive way to guide fluid treatment and …

This study looked at whether keeping steady pressure on the breathing tube's cuff (the balloon that seals the airway) can reduce stomach fluid from leaking into the windpipe in critically ill patients. Researchers measured a stomach enzyme in lung fluids from 122 adults on breath…

This study looked at 186 pregnant women with type 1 or type 2 diabetes to understand how fats (lipids) in the mother's and baby's blood relate to birth weight. Even when blood sugar is well-controlled, babies of diabetic mothers are often larger than average, which can cause deli…

This study looked at 298 children under 6 with early tooth decay in the Hauts-de-France region. Researchers collected data through dental exams and parent questionnaires to understand what factors—like family background, dental habits, and stress—are linked to more severe cavitie…

This study tested whether a device called the ANI monitor can measure pain in sedated children aged 2 and older in the pediatric intensive care unit. Researchers observed 50 children to see if the monitor's readings matched behavioral pain scales. The goal was to find a reliable …

This study measured prolactin levels in 71 people with systemic sclerosis (scleroderma) to see if high levels are common. Researchers compared results with healthy volunteers matched by age and sex. The goal was to understand if prolactin plays a role in the disease, not to test …

This study looked at 214 people with systemic sclerosis (scleroderma) to find out how often calcium deposits form under the skin, especially in the hands and feet. Researchers used X-rays to detect these deposits and checked if they were linked to damage in organs like the lungs,…

This study looked at whether keeping a diary during intensive care can reduce post-traumatic stress disorder (PTSD) in people who survived sudden cardiac arrest and their families. About 173 participants were involved. The goal was to see if writing down what happened helps with …

This study looked at 258 adults with untreated oeso-gastric cancer to understand why some wait longer to see a doctor after noticing symptoms. Researchers examined social, economic, and personal factors that may cause delays. The goal is to help find ways to encourage earlier dia…

This study looked at whether freezing eggs (oocyte cryopreservation) is a good option for women with benign ovarian cysts that keep coming back, like endometriomas or dermoid cysts. These women often need multiple surgeries, which can harm their ovaries and reduce fertility. The …

This study looked at whether a blood test for a substance called ADMA can help measure blood vessel health in children with growth hormone deficiency or those who were small at birth. Researchers compared ADMA levels to ultrasound measurements of artery widening in 23 children. T…

This study looked at how paracetamol (Tylenol) is processed in the body after major liver surgery. Researchers measured paracetamol levels in the blood over five days in 90 patients who had different amounts of liver removed. The goal was to see if patients with less liver tissue…

This study aimed to find normal blood clotting values for healthy pregnant women before and after childbirth using a new device called Quantra. Postpartum hemorrhage is a leading cause of maternal death, and knowing these normal ranges helps doctors quickly spot and treat dangero…

This study tested a new medical device called TOCONAUTE, a patch placed on the mother's belly during labor. It measures the baby's heart rate and the mother's contractions in real time. The goal was to see if this patch works as well as the standard monitor. 60 pregnant women in …