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Could a simple antibiotic boost survival in severe alcoholic hepatitis?

NCT ID NCT02281929

First seen Jan 03, 2026 · Last updated May 19, 2026 · Updated 23 times

Summary

This study looked at whether adding an antibiotic (amoxicillin-clavulanic acid) to the usual steroid treatment could help people with severe alcoholic hepatitis live longer. About 297 adults at high risk of death within two months were given either steroids alone or steroids plus the antibiotic for 30 days. The main goal was to see if the combination improved survival at two months.

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Contacts and locations

Locations

  • CHU

    Angers, France

  • CHU

    Rouen, France

  • CHU

    Toulouse, France

  • CHU Grenoble

    Grenoble, France

  • CHU Montpellier

    Montpellier, France

  • CHU Nantes

    Nantes, France

  • CHU Nice

    Nice, France

  • CHU Poitiers

    Poitiers, France

  • CHU Pontchaillou

    Rennes, France

  • CHU d'Amiens

    Amiens, France

  • CHU de Besançon

    Besançon, France

  • CHU de Caen

    Caen, France

  • Centre Hospitalier

    Valenciennes, 59300, France

  • Centre hospitalier

    Dunkirk, France

  • Hôpital BEaujon (AP-HP)

    Clichy, France

  • Hôpital Claude Huriez, CHU

    Lille, France

  • Hôpital Jean Verdier (AH-HP)

    Bondy, 93143, France

  • Hôpital La Pitié (AP-HP)

    Paris, France

  • Hôpital Paul Brousse (AH-HP)

    Villejuif, 94000, France

  • Hôpital Saint Antoine (AP-HP)

    Paris, 75012, France

Conditions

Explore the condition pages connected to this study.