University Hospital, Lille

This study compares two weight-loss surgeries—sleeve gastrectomy with transit bipartition and Roux-en-Y gastric bypass—in 320 adults with severe obesity. The goal is to see which surgery leads to more weight loss and fewer complications over two years. Participants must have a BM…

This study tests whether transplanting insulin-making cells (islets) into the arm muscle can prevent diabetes in people who need their pancreas removed due to benign disease or injury. The liver is the usual transplant site but can damage the cells. The arm offers a simpler, safe…

This study compares two types of replacement heart valves used in a procedure called TAVI for people with a narrowed aortic valve. About 1,960 participants will be randomly assigned to receive either a balloon-expandable or a self-expanding valve. The goal is to see if one design…

This study tests whether a combination of two drugs (daratumumab and lenalidomide) works better than the current standard treatment for frail older adults with newly diagnosed multiple myeloma who cannot have a stem cell transplant. About 294 participants will receive either the …

This study tests a personalized 2-year educational program for overweight or at-risk children aged 6-8. The goal is to help them lower their body mass index (BMI) and avoid becoming obese adults. Researchers will compare results to a historical group of similar children who did n…

This study looks at how losing weight through either bariatric surgery or a standard diet program affects sexual function and sperm quality in men with severe obesity. About 59 men with a BMI over 25 will take part. The goal is to see which approach leads to better sexual health …

This study looks at whether mepolizumab, a drug already used to reduce asthma attacks, can also help people with severe asthma become more physically active. Researchers will track daily steps and exercise tolerance in 62 adults over six months. The goal is to see if the treatmen…

This study aimed to see if a voice-changing device could make exposure therapy easier for people with PTSD. Patients would read their trauma story aloud while hearing their own voice altered to sound happier or calmer. The goal was to reduce emotional distress and improve therapy…

This study tests whether a specific nerve block (erector spinae plane block) can reduce the amount of morphine needed for pain after minimally invasive spinal fracture surgery. About 86 adults will be randomly assigned to receive either the nerve block or a placebo. The main goal…

This study looks at why women in the Hauts-de-France region of France may wait longer to start breast cancer treatment, which could explain higher death rates there. Researchers will track 500 women recently diagnosed with invasive breast cancer, measuring delays from first sympt…

This study was designed to collect information about pain in people having orthopedic, chest, or gynecological surgery. Researchers planned to use questionnaires to understand pain's physical and emotional aspects and find who might be at risk for long-term pain. However, the stu…

This study tests whether training pediatricians to observe mother-child interactions during routine baby checkups can help identify early signs of child behavior problems or postpartum depression. Over 3,500 mothers and their one-month-old babies took part. The goal is to improve…

This study looks at 2000 people who had a heart attack to see if checking the stiffness of their blood vessels one month later can help predict who will develop heart failure, have another heart attack, or experience bleeding. Participants undergo extra tests like blood vessel st…

This study looks at whether checking the amount of emicizumab in the blood can help predict the risk of bleeding in people with severe hemophilia A. Researchers will follow 100 adults and children who are already taking emicizumab and track any bleeding events over about a year. …

This study was designed to see if giving a carbohydrate drink before weight-loss surgery helps control blood sugar better than the standard fasting approach. It focused on patients with high blood sugar who were scheduled for bariatric surgery. However, the study was withdrawn be…

This study examines 150 preschool children (ages 1 to under 5) hospitalized for a severe asthma attack. Researchers measure immune and inflammatory markers in blood and sputum to see if different wheezing patterns have different underlying causes. Children are followed until age …

This study follows 100 adults with severe chronic sinusitis and nasal polyps who are starting biologic treatments. Researchers will track changes in symptoms and quality of life over six months using standard questionnaires. The goal is to see how well these drugs work in real-wo…

This study aimed to collect medical information from people who developed unusual blood clots within four weeks of receiving a COVID-19 vaccine. The goal was to better understand any possible link between the vaccine and these rare events. However, the study was withdrawn before …

This study was designed to check how well JAK inhibitors work and how safe they are for adults with moderate-to-severe eczema. It planned to track skin improvement, itching, sleep loss, and side effects in a real-world setting in France. However, the study was withdrawn before en…

This study aimed to find biological markers (biomarkers) that could predict how scleroderma would worsen over 10 years. Researchers planned to collect extra blood and urine samples from patients during routine check-ups. However, the study was withdrawn before any participants we…

This study looked at whether COVID-19 patients on breathing machines had more lung infections during the first or second wave of the pandemic. Researchers reviewed medical records from adults in intensive care across Europe. The goal was to understand infection patterns and help …

This study tests whether a rapid PCR test can help doctors choose the right antibiotics within 24 hours for immunocompromised ICU patients with pneumonia. Standard lab tests take days, so patients often get broad antibiotics that may not work well. The trial compares the PCR-guid…

This study aimed to collect medical information from adult cancer patients whose cancer has spread to the bone. The goal was to better understand how and why cancer spreads to bones and how to prevent complications like fractures or pain. No extra tests or visits were required. H…

This study looks at how many kidney transplant patients later regret their choice to have surgery. Researchers will survey 250 adults who received a kidney at Lille University Hospital, asking about regret and quality of life one year after transplant. The goal is to understand h…

This study follows 1,000 elderly patients (65+) who visited a hospital fall clinic in France. Researchers will track their health records for one year to see what leads to unplanned hospital stays. The goal is to find risk factors and improve fall prevention and care.

This study was designed to track daily symptoms of bradykinin-mediated angioedema, a rare condition causing sudden, severe swelling that can be life-threatening. Researchers planned to use a smartphone app to record when attacks happen and what might trigger them. The goal was to…

This study planned to check how the COVID-19 quarantine affected the mental health of people already being treated by a psychiatrist. Researchers wanted to measure symptoms of post-traumatic stress disorder (PTSD) and other mental health issues during quarantine and a few months …