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Liver surgery patients studied for paracetamol safety

NCT ID NCT03297073

Knowledge-focused Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how paracetamol (a common painkiller) is processed in the body after major liver surgery. Researchers measured paracetamol levels in the blood over five days in 90 patients who had different amounts of liver removed. The goal was to understand if patients with less liver tissue are at higher risk of paracetamol toxicity, helping guide safer pain management after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

Nov 2016

Finished

Nov 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients requiring surgery for hepatic resection by initiation under chest or laparoscopic without hepatocellular insufficiency, * ASA score 1 to 3 (American Society of Anesthesiologists score ranging from 1 to 5 evaluating the preoperative health status of a patient), * Verification of the understanding of the protocol, Exclusion Criteria: * Patients classified ASA 4 or 5, * Allergy or intolerance to indocyanine green * Allergy or intolerance to paracetamol, * Taking of paracetamol the week before the intervention, * Patient less than 60 Kgs (because decrease of doses of paracetamol), * Emergency surgery, palliative surgery and surgical recovery, * Psychic disorder, * Contra-indication to a treatment used during the study, * incapable major, * Intellectual incapacity preventing proper understanding of the protocol, * Pregnant or nursing woman,

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Conditions

The condition(s) this trial relates to.

Digestive System Diseases liver disorder paracetamol poisoning

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hepatic disease Paracetamol causing adverse effects in therapeutic use

Contacts and locations

Locations

  • Hôpital Huriez, CHRU

    Lille, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.