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Timing your metformin: before meals may boost carb blocking

NCT ID NCT04018105

Knowledge-focused Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether taking metformin 30 or 60 minutes before a meal affects carbohydrate absorption in people with obesity and prediabetes or type 2 diabetes. One participant completed three oral glucose tolerance tests—one without metformin, one with metformin taken 30 minutes before, and one taken 60 minutes before. Researchers measured blood sugar, insulin, and a sugar marker called D-xylose to see how timing impacts absorption and digestive side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
metformin
What this could lead to
If it works, this could help doctors recommend the best time to take metformin for better blood sugar control.
What could go wrong
This is a very small pilot study with only one participant, so results may not apply to others. It only looks at short-term effects, not long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1 person

The number who actually took part.

Started

Jul 2021

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Obesity (BMI ≥30 kg/m2) * Dysglycemia (HbA1c≥ 6,0 %) * No anti diabetic medication Exclusion Criteria: * No obesity (BMI \< 30 kg/m2) * No dysglycemia (HbA1c \<6,0%) * Treatment that might interfere with carbohydrate absorption (anti diabetic medication, antibiotics, probiotics, steroids) * Anemia (Hb \<12 g/dL) * Organ failure * Inflammatory Bowel Disease

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Conditions

The condition(s) this trial relates to.

glucose intolerance Obesity prediabetes syndrome type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impaired glucose tolerance TYPE2 diabetes

More trials for these conditions

Other studies related to the condition(s) this trial covers.