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Teens born with a rare esophagus condition studied for lifelong health clues

NCT ID NCT05995171

Knowledge-focused Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 300 teenagers born with esophageal atresia, a condition where the esophagus is not fully formed at birth. Researchers will track common long-term problems like acid reflux, breathing issues, and growth, and collect blood and tissue samples to look for biological patterns. The goal is to better understand how this birth defect affects health into adolescence and beyond.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal key health patterns and biological markers that help doctors better manage esophageal atresia as children grow into adults.
What could go wrong
This is an observational study, not a treatment trial. It will not test any new therapy, and results may take years to influence care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2023

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

children aged 13 to 14 born with oesophageal atresia

Ages

13 to 14 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * For the oesophageal atresia group : * Born with oesophageal atresia (EA) in France or in French overseas departments and territories * Anastomosis performed * Included into the ReNaTo registry * Aged 13 or 14 during the recruitment period * Patient willing to comply with all study procedures and duration * Patient will social security For the blood sub-study : * Upper GI endoscopy performed as part of care between 13 and 14 years of age with esophageal mucosal biopsy sampling * Patient having given written consent to participate in the study For the control arm: * Upper GI endoscopy performed as part of care between 10 and 14 years of age with oesophageal mucosal biopsy sampling * Upper GI endoscopy performed as part of care for chronic or acute digestive signs to rule out organic etiology (peptic esophagitis, gastric esophagitis, eosinophilic esophagitis or ulcer) * Normal endoscopy and histology * No chronic progressive disease Exclusion Criteria: * For the oesophagal atresia arm : * Concurrent participation in an interventional trial and in the 3 months prior to inclusion * Parents refusing to participate in the study For the control arm : * Histologically non-normal esophageal biopsy * Parents refusing to participate in the study * Child with known organic pathology

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Conditions

The condition(s) this trial relates to.

esophageal atresia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Esophageal atresia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    33 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AP-HM Hôpital La Timone

    RECRUITING

    Marseille, France

  • AP-HP Hôpital Armand Trousseau

    NOT_YET_RECRUITING

    Paris, France

  • AP-HP Hôpital Kremlin Bicêtre

    NOT_YET_RECRUITING

    Le Kremlin-Bicêtre, France

  • AP-HP Hôpital Necker

    RECRUITING

    Paris, France

  • AP-HP Hôpital Robert Debré

    RECRUITING

    Paris, France

  • CHI Créteil

    RECRUITING

    Créteil, France

  • CHU Amiens

    NOT_YET_RECRUITING

    Amiens, France

  • CHU Angers

    RECRUITING

    Angers, France

  • CHU Besançon

    NOT_YET_RECRUITING

    Besançon, France

  • CHU Bordeaux

    RECRUITING

    Bordeaux, France

  • CHU Caen

    RECRUITING

    Caen, France

  • CHU Clermont-Ferrand

    NOT_YET_RECRUITING

    Clermont-Ferrand, France

  • CHU Dijon

    RECRUITING

    Dijon, France

  • CHU Fort de France

    RECRUITING

    Fort-de-France, Martinique

  • CHU Grenoble

    NOT_YET_RECRUITING

    La Tronche, France

  • CHU Le Mans

    NOT_YET_RECRUITING

    Le Mans, France

  • CHU Limoges

    NOT_YET_RECRUITING

    Limoges, France

  • CHU Montpellier

    RECRUITING

    Montpellier, France

  • CHU Nancy Hôpital Brabois

    NOT_YET_RECRUITING

    Nancy, France

  • CHU Nantes

    RECRUITING

    Nantes, France

  • CHU Nice

    NOT_YET_RECRUITING

    Nice, France

  • CHU Orléans

    NOT_YET_RECRUITING

    Orléans, France

  • CHU Poitiers

    RECRUITING

    Poitiers, France

  • CHU Rouen

    NOT_YET_RECRUITING

    Rouen, France

  • CHU Saint Etienne

    NOT_YET_RECRUITING

    Saint-Etienne, France

  • CHU Strasbourg

    NOT_YET_RECRUITING

    Strasbourg, France

  • CHU Toulouse

    NOT_YET_RECRUITING

    Toulouse, France

  • CHU Tours

    NOT_YET_RECRUITING

    Tours, France

  • CHU de Lille Hôpital Jeanne de Flandre

    RECRUITING

    Lille, Nord, 59000, France

  • CHU de Reims

    NOT_YET_RECRUITING

    Reims, France

  • CHU de Rennes

    RECRUITING

    Rennes, France

  • CHU de Saint Denis de la Réunion

    NOT_YET_RECRUITING

    Saint-Denis, Reunion

  • HLC Hôpital Mère Enfant

    RECRUITING

    Bron, France

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