SEPSIS

This study aims to improve how doctors dose the antibiotic vancomycin in children with sepsis. Researchers want to see if using personalized dosing models, which consider a child's specific kidney function, can help achieve the right drug level—effective against infection while r…

This study is testing whether a drug called fisetin can slow down organ failure in older adults who have developed a mild case of sepsis, a life-threatening response to infection. Researchers will give different doses to 220 hospitalized patients aged 65+ to see which one best im…

This study is collecting real-world information on how well ARTICE therapy works for adults with sepsis or septic shock in intensive care. Researchers will track 200 patients receiving this treatment to see if it improves organ function and survival rates. The goal is to understa…

This early-stage study is testing the safety of a new drug called BAY 3389934 for people with sepsis-induced coagulopathy, a dangerous condition where severe infection causes abnormal blood clotting. Researchers will give the drug to 36 hospitalized ICU patients, starting with lo…

This is a small, early-stage study to see if draining lymph fluid from a chest duct is safe and can lower harmful inflammation in adults with severe septic shock. Researchers will compare a small group of patients who receive the drainage procedure to others who do not. The main …

This study is testing if using a simple finger sensor to guide how much IV fluid a patient gets can help prevent severe skin breakdown in elderly, critically ill patients. Researchers will compare this sensor-guided approach to standard care in 216 older ICU patients with conditi…

This study aims to find the best way to give antibiotics to critically ill sepsis patients in the ICU. It will compare giving antibiotics continuously versus in separate doses, and using one drug versus a combination of two drugs. The main goal is to see which approach leads to b…

This study is testing a new program to help doctors in pediatric intensive care units (PICUs) use a powerful antibiotic called vancomycin more carefully. The goal is to reduce unnecessary prescriptions, which can cause kidney damage, while still effectively treating children with…

This study is testing if having nurses check a patient's small blood vessels (microcirculation) can help spot sepsis patients who are getting worse, even when their main vital signs look okay. The goal is to start giving these patients extra fluids sooner to try to prevent organ …

This study is testing whether an experimental drug called AZD4144 can help improve kidney function in hospitalized adults whose kidneys have been injured by a severe bloodstream infection (sepsis). About 124 participants will be randomly assigned to receive either the drug or a p…

This study is comparing two types of IV fluids given during and after emergency abdominal surgery in adults with sepsis, a life-threatening infection. The goal is to see if a fluid called 'balanced gelatin' helps patients maintain better blood pressure and fluid balance than the …

This study is testing whether a continuous blood filtering treatment helps children with severe bloodstream infections (sepsis) survive and recover better than standard care. Researchers will compare two groups of children to see if early use of this blood purification improves 2…

This large study is comparing two ways to treat life-threatening sepsis right after a patient arrives at the hospital. The standard method is to give fluids first, then add a blood pressure medication if needed. The new method tries giving the blood pressure medication immediatel…

This study is testing whether adding a special immune-boosting drug called Pentaglobin to standard care helps patients with a severe abdominal infection called peritonitis. Researchers will enroll 200 very sick patients to see if the treatment reduces organ failure and death. A k…

This large study aims to determine which intensive care unit (ICU) patients with sepsis might benefit from a 7-day course of steroid medications (hydrocortisone and fludrocortisone) compared to a placebo. It will enroll 1800 adults to see if specific biological markers can identi…

This study is testing if a specific nerve block injection can help improve organ function in patients with severe infections (sepsis) who also have significant gut injury. Researchers will compare patients who receive the nerve block to those who receive standard care alone. The …

This study is testing whether a new, more personalized method for dosing a common antibiotic (cefepime) works better for very sick patients in the ICU with serious infections like sepsis. The main goal is to see if doctors and nurses find the new dosing method easy to use in a re…

This early-stage study is testing the safety of a new intravenous treatment called DNase I for patients with sepsis in intensive care. The treatment aims to break down harmful webs released by the immune system that can clog blood vessels and damage organs. Researchers will enrol…

This study aims to help babies with serious infections like sepsis get the right dose of a key antibiotic (vancomycin) faster. Currently, doctors must wait 1-2 days to check if the dose is correct, delaying optimal treatment. Researchers are testing if checking drug levels after …

This study is testing if giving an oral medication called midodrine early on can help people with sepsis and low blood pressure get off strong intravenous (IV) medications sooner. Researchers hope this will lead to shorter stays in the intensive care unit and hospital, and a more…

This study is testing if tracking how a blood marker called procalcitonin changes over time is better than using a single high reading to decide when to start antibiotics in intensive care patients with a suspected infection. It aims to reduce unnecessary antibiotic prescriptions…

This study is testing a computer alert system in hospital records to help doctors decide when to add a second blood pressure medication (vasopressin) for patients with severe septic shock. It will enroll 300 adults in a specific ICU to see if the system can create two groups: one…

This study is testing whether a new drug called YD0743 can help adults in the ICU with sepsis-related acute respiratory distress syndrome (ARDS). Researchers want to see if the drug can reduce the number of days patients need a breathing machine and improve their chances of survi…

This study is testing two different types of filters used in a blood-cleaning treatment for children with sepsis, a life-threatening response to infection. The goal is to see which filter is better at removing harmful inflammation-causing substances from the blood, which could he…

This study is testing a two-step blood filtering treatment for people with sudden liver failure on top of chronic liver disease who also have a severe bloodstream infection (sepsis). Researchers want to see if this procedure, which removes harmful inflammatory substances from the…

This study is testing if a personalized approach to giving fluids is safer and more effective than the standard one-size-fits-all method for treating sepsis in the emergency room. Sepsis is a life-threatening reaction to infection that requires rapid treatment. Researchers will c…

This study aims to find new biological markers in the blood to help doctors diagnose sepsis more quickly and accurately in emergency room patients. Researchers will compare the immune responses of 3,300 adults who come to the ER with suspected infections, tracking who develops se…

This study aims to create a computer program (AI) that can quickly identify sepsis by analyzing existing hospital patient records. Researchers will look at data from 10,000 adult patients who spent time in intensive care. The goal is to see if this AI tool can help doctors diagno…

This study is testing a new device called PIVO to see if it can be used to draw blood for infection tests through an existing IV line in emergency room patients. The goal is to reduce the number of separate needle sticks a patient needs while still getting accurate test results. …

This study is testing how accurate and reliable a new continuous glucose monitoring system is for critically ill patients in intensive care. Researchers will place small sensors on patients' arms to measure blood sugar continuously, then compare these readings to standard blood t…

This study aims to improve how doctors tell the difference between several serious conditions that look very similar: adult-onset Still's disease, sepsis, and other severe inflammatory syndromes. Researchers will test a specific blood marker called 'glycosylated ferritin' in 60 p…

This study is testing a computer tool called pediatric eCART that uses a child's health records to quickly calculate their risk of getting much sicker in the hospital. It will compare outcomes for 30,000 children before and after the tool is introduced to see if it helps doctors …

This study is testing whether using a virtual reality headset in the intensive care unit (ICU) can help patients relax, improve their mood, and keep their minds active. Patients with conditions like severe breathing problems or sepsis will try VR sessions with breathing exercises…

This study aims to understand why some people who survive severe injuries later develop serious infections and long-term health problems. Researchers will collect blood and bone marrow samples from 255 adults with major trauma injuries and compare them to samples from people havi…

This study aims to understand how a powerful antibiotic moves through and works in the bodies of children with severe infections who are on life support. Researchers will observe 30 children already receiving this antibiotic as part of their standard hospital care. The goal is to…

This study aims to understand why some critically ill patients develop sudden kidney injury. Researchers will measure inflammation markers in the blood, urine, and sputum of 100 patients in intensive care with sepsis, after major surgery, or after chemical poisoning. The goal is …

This study aims to understand how sepsis survivors recover their physical strength after leaving the hospital. Researchers will follow 40 patients who survived sepsis in the ICU, tracking their physical function over time to identify different recovery patterns. The goal is to fi…

This study aims to understand how common and severe enterovirus infections are in newborns in Italy, with a focus on a specific strain called Echovirus 11. Researchers will collect and analyze samples from 1,600 babies admitted to neonatal intensive care units to learn more about…

This study is testing a new blood analysis method to track organ damage and immune system exhaustion in people with sepsis. Researchers will enroll 1,000 adult patients with sepsis to see if specific markers in the blood can reveal which organs are being affected and how severely…

This study aims to understand why people who survive a serious illness in the Intensive Care Unit (ICU) often have long-lasting muscle weakness and trouble exercising. Researchers will measure heart and lung fitness, as well as blood flow in the muscles, in 50 ICU survivors at 6 …

This study aims to better understand ARDS, pneumonia, and sepsis by observing 4,000 hospitalized adults with these serious conditions. Researchers will collect health data, questionnaires, and samples like blood and urine from participants during and after their hospital stay. Th…

This study aims to find out if giving platelet transfusions to intensive care patients with sepsis and low platelet counts helps them survive or causes more harm. Researchers will look back at the medical records of 1,500 patients to see if those who received transfusions had bet…

This study aims to better understand serious Bacillus cereus infections in premature babies hospitalized in France. Researchers will analyze bacteria samples from 40 infected newborns to identify which strains are most dangerous and what factors lead to worse outcomes. The goal i…

This study follows 300 critically ill children who survived sepsis for five years after leaving the hospital. Researchers want to understand how sepsis affects long-term growth, brain development, survival rates, and quality of life. The study compares these children to similar c…

This study aims to learn if measuring a patient's extracellular water (fluid outside their cells) can help doctors better understand unstable blood pressure in sepsis. Researchers will enroll 20 adult sepsis patients in intensive care and add this special water measurement to the…

This study aims to understand how a specific type of white blood cell, called a neutrophil, behaves in children with sepsis, a life-threatening infection. Researchers will compare blood samples from children with sepsis to those without to see how these cells change and potential…

This study aims to understand how harmful blood clots form in the smallest blood vessels of patients with severe sepsis (septic shock) who need kidney dialysis. Researchers will compare two different types of dialysis filters to see if one affects the levels of substances linked …

This study is an anonymous online survey for doctors, nurses, and midwives in seven African countries. It aims to measure their current knowledge about sepsis—a life-threatening body-wide infection—to identify where training is most needed. The survey will be repeated to see if n…

This study aims to better understand a specific type of white blood cell (neutrophil) in children with sepsis, a life-threatening body-wide infection. Researchers will compare these cells from the blood and lungs of children with sepsis to those from children without it. The goal…

This study aims to understand why sepsis damages the immune system, leaving survivors vulnerable to serious infections for weeks or months afterward. Researchers will analyze blood samples from 150 ICU patients with sepsis, comparing them to patients without sepsis and healthy vo…

This study is testing new artificial intelligence (AI) tools designed to help doctors make better decisions for patients with heart conditions, breast cancer, or sepsis. It will use past patient records to see if the AI can provide safe, understandable recommendations. The goal i…

This study aims to find biological markers that can predict which sepsis patients will get much worse and develop septic shock. Researchers will compare blood samples from 25 male patients who have sepsis after major digestive cancer surgery. They are looking for differences betw…

This study aims to understand how the immune system responds during and after sepsis, a life-threatening reaction to infection. Researchers will follow 400 intensive care patients with sepsis, collecting blood samples and health information over one year to identify different imm…

This study aims to understand if certain genetic elements cause the immune system to age prematurely in people hospitalized with sepsis. Researchers will track 116 adult ICU patients with sepsis to see if these genetic markers are linked to higher risk of death or secondary infec…

This study aims to understand why some people don't recover well after a severe infection (sepsis) or major injury. Researchers will observe 450 adults with sepsis or severe trauma to see how their immune system cells change over time. The goal is to learn what causes long-term i…

This study aims to understand how long a special blood filter keeps working effectively in adults with septic shock, a life-threatening infection. Researchers will observe 29 patients in intensive care who are already receiving this filter as part of their standard treatment. By …

This study is creating a large international registry to collect real-world data on how a medical device called CytoSorb is used in critical care. The device filters harmful substances from a patient's blood and is used for various severe conditions like septic shock, severe trau…

This study aims to find out if a simple blood test can help predict which elderly patients are at higher risk for serious complications or death after hip fracture surgery. Researchers will follow 100 patients aged 65+ to see if a blood marker called MDW, measured during routine …

This study aims to understand the biology of life-threatening conditions like sepsis and ARDS by observing 1,000 critically ill patients in the ICU. Researchers will collect blood and fluid samples to identify early biological signs that could lead to faster diagnosis and better …