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Quick neck scan may prevent fluid overload in ICU sepsis patients

NCT ID NCT07653568

Knowledge-focused Sponsor: Pakistan Institute of Medical Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a simple neck ultrasound can tell if a septic patient on a ventilator needs more fluids. Doctors will compare this quick method to a standard heart ultrasound. If it works, it could help avoid giving too much or too little fluid, which can be dangerous. The study involves 94 adults in the intensive care unit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 94 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Adults with sepsis requiring mechanical ventilation in the intensive care unit * Patients requiring fluid assessment or fluid resuscitation based on clinical findings, including one or more of the following: * Heart rate greater than 100 beats per minute * Systolic blood pressure less than 90 mmHg * Mean arterial pressure less than 65 mmHg * Urine output less than 0.5 mL/kg/hour for at least 2 hours Exclusion Criteria: * Intracranial pathology associated with raised intracranial pressure, including intracerebral hemorrhage or space-occupying lesions * Recent neurosurgical procedures or conditions where passive leg raising may increase intracranial pressure * Known heart failure * Significant cardiac arrhythmias * Significant valvular heart disease * Status asthmaticus * Pulmonary hypertension * Pulmonary embolism * Pregnancy * Lower limb conditions preventing passive leg raising, including fractures * Intra-abdominal hypertension * Recent abdominal surgery * Known carotid artery disease or common carotid artery stenosis greater than 50%

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Conditions

The condition(s) this trial relates to.

infectious disease with sepsis Sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fluid responsiveness predictability in sepsis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Pakistan Institute Of Medical Sciences

    RECRUITING

    Islamabad, Federal Area, 44000, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.