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Massive registry launched to see if Blood-Filtering device helps sickest patients

NCT ID NCT05146336

Knowledge-focused Sponsor: CytoSorbents, Inc Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, shock, and organ failure, but does not test the device against a control group.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CytoSorb device (a blood-filtering cartridge used in intensive care)
What this could lead to
If successful, this registry could help doctors understand when and how to best use CytoSorb to improve survival in critically ill patients.
What could go wrong
This is an observational registry, not a controlled trial, so it cannot prove the device works. Results may be influenced by differences in patient care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 3,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2022

Expected to finish

Sep 2032

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Critically ill patients receiving CytoSorb therapy

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Planned OR actual CytoSorb® 300 mL device utilization 2. Informed consent for prospective registry participation Exclusion Criteria: 1. Use of the CytoSorb® 300 mL device for antithrombotic removal only 2. Intraoperative use of CytoSorb® 300 mL device during cardiac surgery only 3. The occurrence of a complication or other medically justified circumstance that arises after written informed consent has been obtained from the patient and before or during the planned therapy and as a result of which the use of CytoSorb® 300 mL Adsorber is contraindicated or no longer appropriate.

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Conditions

The condition(s) this trial relates to.

acute liver failure acute respiratory distress syndrome Acute-On-Chronic Liver Failure adult acute respiratory distress syndrome burn cardiogenic shock cytokine release syndrome Drug Overdose hemophagocytic syndrome infectious disease infectious disease with sepsis injury Lymphohistiocytosis, Hemophagocytic pancreatitis poisoning Rhabdomyolysis Sepsis Shock, Cardiogenic toxic shock syndrome Vasoplegia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute liver failure Acute respiratory distress syndrome Acute-on-chronic liver failure Burns Cardiogenic shock Chimeric antigen receptor T-cell therapy (car-T) cytokine release syndrome (CRS) Drug overdose Extracorporeal life support Hemophagocytic lymphohistiocytoses Infectious disease Liver transplant; complications Pancreatitis Postoperative endocarditis Postoperative vasoplegic syndrome Rhabdomyolysis Sepsis Septic shock Trauma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    25 sites in 6 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil Bochum

    RECRUITING

    Bochum, 44789, Germany

  • Deutsches Herzzentrum München

    RECRUITING

    München, 80636, Germany

  • Helios Dr. Horst Schmidt Kliniken Wiesbaden

    RECRUITING

    Wiesbaden, 65199, Germany

  • Herz- und Diabeteszentrum Nordrhein-Westfalen

    RECRUITING

    Bad Oeynhausen, 32545, Germany

  • Hospital Juan Ramón Jimenez

    RECRUITING

    Huelva, Spain

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, Barcelona, 08035, Spain

  • IRCCS Ospedale Casa Sollievo della Sofferenza

    RECRUITING

    San Giovanni Rotondo, 71013, Italy

  • Katholisches Klinikum Bochum, St. Josef-Hospital

    RECRUITING

    Bochum, 44791, Germany

  • Kliniken Maria Hilf

    TERMINATED

    Mönchengladbach, 41063, Germany

  • Klinikum Herford

    RECRUITING

    Herford, 32049, Germany

  • Klinikum Kassel

    WITHDRAWN

    Kassel, 34125, Germany

  • Klinikum Klagenfurt am Wörthersee

    RECRUITING

    Klagenfurt, 9020, Austria

  • Klinikum Oldenburg

    RECRUITING

    Oldenburg, 26133, Germany

  • LMU Klinikum München

    RECRUITING

    München, Germany

  • Medizinische Universität Wien

    RECRUITING

    Vienna, 1090, Austria

  • Ospedale Pediatrico Bambino Gesù

    TERMINATED

    Roma, 00165, Italy

  • SP ZOZ Szpital Uniwersytecki w Krakowie

    RECRUITING

    Krakow, 30-688, Poland

  • ULS São José, Hospital Curry Cabral

    RECRUITING

    Lisbon, Portugal

  • Unidade Local de Saúde de Coimbra E.P.E

    RECRUITING

    Coimbra, 3004-561, Portugal

  • Universitätsklinikum Aachen

    RECRUITING

    Aachen, 52074, Germany

  • Universitätsklinikum Essen, Medizinische Intensivtherapie

    RECRUITING

    Essen, 45147, Germany

  • Universitätsklinikum Essen, Nephrologie

    RECRUITING

    Essen, 45147, Germany

  • Universitätsklinikum Essen, Thorax- und Kardiovaskuläre Chirurgie

    RECRUITING

    Essen, 45147, Germany

  • Universitätsklinikum Jena

    RECRUITING

    Jena, 07747, Germany

  • Universitätsklinikum Marburg

    RECRUITING

    Marburg, 35043, Germany

  • Universitätsmedizin Göttingen, Allgemein-, Viszeral- und Kinderchirurgie

    RECRUITING

    Göttingen, 37075, Germany

  • Universitätsmedizin Göttingen, Herzzentrum Göttingen

    RECRUITING

    Göttingen, 37075, Germany

  • Uniwersyteckim Spitalem Klinicznym im. Jana Mikulicza - Radeckiego we Wrocławiu

    RECRUITING

    Wroclaw, 50-556, Poland

More trials for these conditions

Other studies related to the condition(s) this trial covers.