ACUTE LIVER FAILURE

This study tests a machine that cleans the blood for people whose livers suddenly stop working. The treatment combines two filtering methods (DPMAS and TPE) to remove toxins and support the body. Researchers will check if it helps patients survive for 21 days without needing a li…

This study tests a new drug called F573 in people with liver injury or liver failure. The goal is to see if it is safe and how it affects the body. About 97 adults will take part, and half will get the drug while the other half gets a placebo. The study focuses on safety and does…

This study tests whether using a standard amount of plasma exchange works as well as a high amount in children with acute liver failure. The goal is to help the liver recover on its own and avoid the need for a transplant. About 40 children aged 3 to 18 will be randomly assigned …

This study tests whether two drugs that calm the immune system—high-dose steroids or a medicine called anti-thymocyte globulin—can help children with sudden, severe liver failure survive without needing a liver transplant. About 163 children aged 1 to 17 will be randomly assigned…

This study is gathering information from 10,000 liver transplant patients across Europe to create a new, up-to-date reference for what good outcomes look like when donor livers are preserved using machine perfusion. The goal is to help doctors better understand which preservation…

This study is a large registry that collects data on how a blood-filtering device called CytoSorb is used in real-world intensive care settings. It will include up to 3,000 critically ill patients with conditions like septic shock, severe lung injury, or liver failure. The goal i…