Can calming the immune system save Children's livers?
NCT ID NCT04862221
First seen Oct 31, 2025 · Last updated May 19, 2026 · Updated 39 times
Summary
This study tests whether two drugs that calm the immune system—high-dose steroids or a medicine called anti-thymocyte globulin—can help children with sudden, severe liver failure survive without needing a liver transplant. About 163 children aged 1 to 17 will be randomly assigned to receive one of these drugs or a placebo. The main goal is to see if more children are alive with their own liver 21 days after treatment starts.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
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Children's Healthcare of Atlanta - Arthur M. Blank Hospital
WITHDRAWNAtlanta, Georgia, 30322, United States
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Children's Hospital Boston
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
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Children's Hospital Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
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Children's Hospital Vanderbilt
RECRUITINGNashville, Tennessee, 37232, United States
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Children's Hospital of Pittsburgh
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
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Cleveland Clinic Children's
WITHDRAWNCleveland, Ohio, 44195, United States
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Duke University Medical Center - Duke Children's
WITHDRAWNDurham, North Carolina, 27710, United States
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Lucile Packard Children's Hospital
RECRUITINGPalo Alto, California, 94304, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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NYP Morgan Stanley Children's Hospital
RECRUITINGNew York, New York, 10032, United States
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Primary Children's Medical Center
WITHDRAWNSalt Lake City, Utah, 84112, United States
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Rady Children's Hospital
RECRUITINGSan Diego, California, 92123, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Riley Hospital for Children
RECRUITINGIndianapolis, Indiana, 46202, United States
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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St. Louis Children's Hospital
RECRUITINGSt Louis, Missouri, 63110, United States
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Texas Children's Hospital
RECRUITINGHouston, Texas, 77030, United States
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The Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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The Children's Mercy Hospital
RECRUITINGKansas City, Missouri, 64108, United States
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The Mount Sinai Medical Center
WITHDRAWNNew York, New York, 10029, United States
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UT Southwestern Medical Center Children's Health
RECRUITINGDallas, Texas, 75235, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California San Francisco Benioff Children's Hospital
WITHDRAWNSan Francisco, California, 94158, United States
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Yale New Haven Children's Hospital
WITHDRAWNNew Haven, Connecticut, 06510, United States
Conditions
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